|
The document details a 19F-NMR spectral analysis conducted by 3M Specialty Adhesives & Chemicals on a fluorochemical sample (FC-95, lot # 217) to identify and quantify its isomers and impurities, revealing specific relative concentrations of various fluorochemical components.
|
1997 |
AR226-0564
|
oeyqvDwrgzOE7MKGgE8EMdgy8 |
2 |
|
The document provides information on the chemical identification and manufacturing process of Perfluorooctane sulfonamido ethyl acetate (PFOSSA), including details about its production by 3M Company using the Simons Electro-Chemical Fluorination method.
|
1997 |
AR226-0578
|
6BqJe4jxOgZz82B4GobwV18jE |
13 |
|
The document provides a voluntary use and exposure information profile for Perfluorodecane sulfonate (PDSF), including its chemical identification, manufacturing process by 3M Company, and notes that PDSF is not commercially viable but serves as an intermediate in the production of perfluorodecane sulfonates.
|
1997 |
AR226-0579
|
oDM18Z8dvovmgZzvRdD7RYmDr |
12 |
|
The document provides information on N-ethyl perfluorooctanesulfonamide (EtFOSA), including its production by 3M Company using the Simons Electro-Chemical Fluorination process, with an estimated off-site distribution of 59% of the less than 100,000 lbs manufactured.
|
1997 |
AR226-0580
|
yppvG190DqK12v3wX0xdZgQ06 |
23 |
|
The document provides information on N-methyl perfluorooctanesulfonamido ethanol (MeFOSE), a chemical produced by 3M Company using the Simons Electro-Chemical Fluorination process, detailing its synthesis and distribution, with less than 2% estimated to be distributed off-site.
|
1997 |
AR226-0583
|
NEj5915j72V0p0GyYqEevqLp8 |
23 |
|
The document is a final report of a mutagenicity test on T-6564 conducted by Coming Hazleton Inc. for 3M Corporation, utilizing an in vivo mouse micronucleus assay to assess the potential mutagenic effects of the substance.
|
1996 |
AR226-0430
|
aBb3Oxdb0oNJ89KV9kpmXrVBY |
26 |
|
The document is a final report on a mutagenicity test conducted by Corning Hazleton Inc. for 3M Corporation, measuring chromosomal aberrations in Chinese hamster ovary (CHO) cells using the substance T-6564, with compliance to Good Laboratory Practice regulations.
|
1996 |
AR226-0431
|
x3qqNgjQBZ6a5eGXGKrjwDbg |
30 |
|
The document is a final report on a mutagenicity test of a substance (T-6564) conducted by Coming Hazleton Inc. for 3M Corporation, using the Salmonella - Escherichia coli/mammalian-microsome reverse mutation assay, which was completed in compliance with Good Laboratory Practice regulations.
|
1996 |
AR226-0432
|
gb01QkaVpG6767OmmqVnM1aGQ |
34 |
|
The document is a final report on a mutagenicity test conducted by Corning Hazleton for 3M Corporation, measuring chromosome aberrations in human whole blood lymphocytes using the substance T-6342, with the study completed on November 1, 1996, and found to comply with Good Laboratory Practice regulations.
|
1996 |
AR226-0433
|
Yay5Yp6kN6b75BJ5M3KM7GyN |
29 |
|
The document is a final report on a mutagenicity test conducted by Corning Hazleton for 3M Corporation, measuring chromosomal aberrations in Chinese hamster ovary (CHO) cells related to the substance T-6342.
|
1996 |
AR226-0434
|
JJnDbD4JB8gNQ0z6m9bXrDXK6 |
35 |
|
The document discusses a study by Gilliland and Mandel that evaluates the effects of serum perfluorooctanoic acid (PFOA) on hepatic enzymes, lipoproteins, and cholesterol in 115 occupationally exposed men, finding no significant clinical hepatic toxicity at measured PFOA levels, although it suggests PFOA may interact with obesity and alcohol effects on liver function, with subsequent studies
|
1996 |
AR226-0475
|
rxNb854pX1m9q89MBwJZoqREV |
8 |
|
The document reports the results of a Microbios Microtox toxicity test conducted on perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), indicating that the 30-minute EC50 value was 730 mg/L, suggesting low acute toxicity to the test organism Photobacterium phosphoreum.
|
1996 |
AR226-0521
|
2yergERkgBrE81mBO3XyRkj6 |
6 |
|
The document details a Microtox toxicity test conducted on a mixture containing perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), specifically the test sample FC-1015-X, to evaluate its toxicity using Photobacterium phosphoreum, although the purity of the sample was not sufficiently characterized.
|
1996 |
AR226-0523
|
3Q6XyDabbE152mdrnDk1oYmj0 |
6 |
|
The document reports the results of a Microbios Microtox toxicity test on perfluorooctanoic acid ammonium salt (PFOA ammonium salt), indicating an EC50 value of 4460 mg/L at 5 minutes and 3360 mg/L at 15 minutes, although the test sample's purity was not sufficiently characterized.
|
1996 |
AR226-0522
|
Rj55pZjVLMy45y0eoLZvXLQQ7 |
8 |
|
The document describes an activated sludge respiration inhibition test conducted on a sample of perfluorooctanoic acid, ammonium salt (PFOA), specifically the FC-1015-X product from 3M, noting that the purity was not sufficiently characterized and that the data may not accurately reflect the toxicity of the test substance due to impurities.
|
1996 |
AR226-0524
|
XMq3aKepeLrqn8o494qMMNVg |
9 |
|
The document details a toxicity test of perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), specifically examining its effects on the aquatic plant species Selenastrum capricornutum using a mixture from the 3M product FC-1015, with findings indicating potential discrepancies in toxicity data due to impurities in the test sample.
|
1996 |
AR226-0526
|
aEr8raKrgXpQYmQjLdvgeKpb |
23 |
|
The document reports on an acute toxicity test of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) on Daphnia magna, indicating that the test sample was a mixture with incompletely characterized impurities and was compared to a straight carbon chain version of the substance.
|
1996 |
AR226-0527
|
MGOv20q3kpBwG3R8Z6QpNKxvM |
28 |
|
The document details an acute toxicity test of perfluorooctylsulfonate, a compound produced by 3M, on the fish species Pimephales promelas, using a 96-hour exposure method to assess its effects in a laboratory setting.
|
1996 |
AR226-0534
|
zR46DjzYqL6BR2ax7KnvJXvB |
11 |
|
The document details an acute toxicity test of Perfluorooctylsulfonate (CAS # 251099-16-8) on the aquatic invertebrate Daphnia magna, conducted using a mixture of the test substance and water, with specific monitoring and statistical methods employed to determine toxicity levels.
|
1996 |
AR226-0535
|
2jy0aDDzznEY4rkv1oY4QBvOg |
11 |
|
The document details a Microtox toxicity test conducted on a mixture containing perfluorooctylsulfonate, didecyldimethylammonium salt, produced by 3M, indicating the test sample's composition and preparation methods, but does not provide specific toxicity results.
|
1996 |
AR226-0538
|
YDj9BVapKDJ29KzX3jgRe1R6y |
7 |
|
The document reports on a biodegradation study of the perfluorinated compound 2-(N-Ethylperfluorooctanesulfonamido)ethyl acrylate (B1228), indicating low biodegradability (4-6%) after 28 days, with concerns about the purity and methodology of the test.
|
1995 |
AR226-0412
|
ymnMJmq2X630vZEvdLnrxV7jX |
35 |
|
The document is a final report on an acute dermal toxicity study of T-6342, sponsored by 3M and conducted by Corning Hazleton Inc. in accordance with OECD guidelines.
|
1995 |
AR226-0427
|
3ed556NwEoYqXKbZ6ZDz3qKza |
32 |
|
The document is a final report on a mutagenicity test of T-6342 conducted by Corning Hazleton for 3M Corporation, indicating compliance with Good Laboratory Practice regulations and detailing quality assurance inspections related to the study.
|
1995 |
AR226-0435
|
4ak7yqq3oKRBRLB9QRz7Np19e |
23 |
|
The document is a final report of a mutagenicity test conducted by Corning Hazleton for 3M Corporation, assessing the mutagenic potential of a substance (T-6342) using the Salmonella - Escherichia coli/mammalian-microsome reverse mutation assay, completed on December 14, 1995.
|
1995 |
AR226-0436
|
6Bb8vw84b9YG27NGKxGY1vvy3 |
30 |
|
The document details a bioconcentration test of perfluorooctanoic acid (PFOA) ammonium salt, produced by 3M, using fathead minnows to analyze the uptake and depuration of PFOA over a specified period, although the purity of the test sample was not fully characterized.
|
1995 |
AR226-0496
|
a15NbOxGL9xM3ejJJjpX230JY |
24 |
|
The document details a toxicity study of Perfluorooctanoic acid (PFOA) on the aquatic plant species Selenastrum capricornutum, conducted under U.S. EPA guidelines, with the test completed in 1996.
|
1995 |
AR226-0518
|
DG7ZqaYDe968OQoLJ2pXXwMKo |
28 |
|
The document details an acute toxicity study of perfluorooctanoic acid (PFOA) conducted in 1995-1996 on the fish species Pimephales promelas, using a test substance with a purity of 96.5-100% PFOA and a 50:50 water-isopropanol solution for sample preparation.
|
1995 |
AR226-0519
|
2R5Eorxp8N5y9y769yO6Qzmr6 |
29 |
|
The document details a 1995-1996 acute toxicity study of perfluorooctanoic acid (PFOA) on the aquatic invertebrate Daphnia magna, conducted under U.S. EPA guidelines, which involved monitoring various environmental parameters and calculating LC50 and EC50 values.
|
1995 |
AR226-0520
|
LJYZ2OrK9DaoG6k4MOmkyrLGg |
29 |
|
The document reports the results of a study conducted by 3M Company to estimate the log Pow (partition coefficient) for N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), finding values of 5.6 and 4.4 for different peaks.
|
1994 |
AR226-0379
|
5bVvMJ5MGEvwjGJbvLr1ROeGJ |
17 |
|
This document is a research article discussing the prevention of fluvastatin-induced toxicity, mortality, and cardiac myopathy in pregnant rats through mevalonic acid supplementation, authored by Roman V. Hrab and colleagues from Sandoz Pharmaceuticals.
|
1994 |
AR226-0559
|
dQgzxZGVm6mdJ69wjj35185q6 |
8 |
|
This document is a final report on a 13-week dietary toxicity study of Ammonium Perfluorooctanoate (PFOA) conducted by Hazleton Wisconsin, Inc. for 3M, confirming compliance with EPA Good Laboratory Practice Standards.
|
1993 |
AR226-0449
|
em8YYDkbanqOe9vm5a5aexyDg |
239 |
|
The document is a final report on a 13-week dietary toxicity study of Ammonium Perfluorooctanoate (T-5180) conducted by Hazleton Laboratories for 3M, detailing various organ weight data and pathology results in male rats.
|
1993 |
AR226-0450
|
vdvV0OMpoDMVrBzzze0YQMj6 |
428 |
|
This document discusses a mortality study of employees at a 3M perfluorooctanoic acid (PFOA) production plant, indicating no significant overall increase in mortality but noting a 3.3-fold increase in prostate cancer mortality among those employed for ten years or more in the chemical division, with caution advised due to limited data on direct PFOA exposure.
|
1993 |
AR226-0472
|
06bedZkxDqEM0rp3L0pdjy24m |
7 |
|
The document reports on an acute toxicity test of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) conducted on juvenile fish (Pimephales promelas) using a test sample (FC-1015) with unspecified purity, indicating potential toxicity differences between branched and straight chain perfluorooctanoate homologues.
|
1993 |
AR226-0525
|
DG7MLOawdbO7Z2E5b6w2rnwa4 |
22 |
|
The document reports on an acute toxicity test of perfluorodecanesulfonate (PFDS) on the aquatic invertebrate Daphnia magna, conducted by 3M in 1992, using a test sample mixture and measuring various water chemistry parameters, although the concentration of the test substance was not monitored.
|
1992 |
AR226-0384
|
2Nv5JBBnzzEBk5nGxXaOxgZBb |
17 |
|
The document reports on an activated sludge respiration inhibition test for Perfluorodecanesulfonate (PFDS), indicating that it exhibited a 17.3% inhibitory effect on respiration at a concentration of 1000 mg/L after a 3-hour exposure.
|
1992 |
AR226-0385
|
Z49vMZgp4wvnjgVjZG2j3Lpa8 |
9 |
|
The document reports on a Microtox toxicity test conducted by 3M Company on perfluorodecanesulfonate (PFDS), indicating a 30-minute EC50 value of 327 mg/L for the test organism Photobacterium phosphoreum, while noting the limitations of testing a mixture rather than the pure substance.
|
1992 |
AR226-0386
|
4J0eD24OLn5n1kJj9L3V9GeYN |
12 |
|
The study investigates the hypolipemic effects of perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOSA) on lipid metabolism in male Wistar rats, finding that both compounds significantly reduce serum cholesterol and triacylglycerol levels while altering liver lipid synthesis and enzyme activities.
|
1992 |
AR226-0557
|
2NR2yO32Kp4opoQ9owBz3k3R5 |
8 |
|
The document reports on a biodegradation study of perfluorodecanesulfonate (PFDS) conducted by 3M, indicating that while the non-fluorinated moiety butyl cellosolve is likely to be biodegraded in aerobic environments, the potential for biodegradation of the fluorochemical component remains uncertain.
|
1991 |
AR226-0382
|
K84QddMedJG9KGOYNJRbd9EK |
8 |
|
This doctoral thesis by Dr. Frank Gilliland analyzes the health effects of perfluorooctanoate (PFOA) in employees at the Chemolite manufacturing plant, finding no significant hepatic toxicity but suggesting associations between PFOA levels and male reproductive hormones, particularly in older men.
|
1990 |
AR226-0473
|
rgm1ayY2kBR1kKXdeyp1nmKJ |
294 |
|
The document reports on the completion of health examinations for 426 individuals associated with 3M's Chemolite operations in 1990, including blood fluoride tests and hormonal assessments to evaluate the effects of fluoro-chemicals, with a participation rate of 84%.
|
1990 |
AR226-0485
|
aJZNmMv8nMYY2egv9Ndgm32MB |
4 |
|
The document reports on an activated sludge respiration inhibition test for perfluorooctanoic acid ammonium salt (PFOA ammonium salt) produced by 3M, indicating that the 30-minute and 3-hour EC50 values were both greater than 1,000 mg/L, suggesting low toxicity at the tested concentrations.
|
1990 |
AR226-0514
|
ykbQy4G96GyRQLZDELax273J2 |
7 |
|
The document reports on a Microtox toxicity test conducted on a test sample of perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), indicating that the EC50 values for Photobacterium phosphoreum were greater than 1,000 mg/L at 5, 15, and 30 minutes, suggesting low toxicity.
|
1990 |
AR226-0515
|
3pqNoYY4jwD88Bjxa3nKeyrD |
6 |
|
The document details an acute toxicity test of perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), conducted on juvenile Pimephales promelas (fathead minnows) using a test sample (FX-1003) with unspecified purity, following OECD 203 guidelines.
|
1990 |
AR226-0516
|
3JvE0KXMkYLZ41jee85B2b17E |
25 |
|
The document details an acute toxicity test of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) on the aquatic invertebrate Daphnia magna, conducted by 3M, using a test sample (FX-1003) with unspecified purity and composition, under OECD guidelines.
|
1990 |
AR226-0517
|
r6yZ5xz1gR0ZDrE8K0eawXpr |
25 |
|
The document reports on an acute toxicity study of Perfluorodecanesulfonate (PFDS) conducted on the fish species Pimephales promelas, revealing a 96-hour LC50 value of 13 mg/L and a NOEL of 3.2 mg/L.
|
1988 |
AR226-0388
|
Oz7a2ZaY4jgxERDx312qZ8BDX |
8 |
|
This document appears to be a scientific article discussing developmental changes in gene expression related to cholesterol biosynthesis and lipid transport in human and rat fetal and neonatal livers, authored by researchers from Washington University and UCLA.
|
1988 |
AR226-0558
|
3JN4Bw3kmYRbvp32vjLvggvj3 |
8 |
|
This document reports on a biodegradation study of perfluorodecanesulfonate (PFDS) conducted by 3M, indicating that while the non-fluorinated moiety (propanol) is likely to biodegrade in aerobic environments, the potential for biodegradation of the fluorinated component remains uncertain.
|
1987 |
AR226-0387
|
gbLbOb6w8mzKO7onym3pj6ZgJ |
8 |
|
The document reports on an activated sludge respiration inhibition test for perfluorodecanesulfonate (PFDS) produced by 3M, finding a 3-hour EC50 value of 780 mg/L for the test substance in a mixture.
|
1987 |
AR226-0390
|
ZJYpjxBZwgxOx9pZY543MNgeZ |
3 |
|
The document reports on a Microbios Microtox toxicity test conducted by 3M Company on a mixture containing perfluorodecanesulfonate (PFDS), revealing a 15-minute EC50 value of 290 mg/L for the test organism Photobacterium phosphoreum.
|
1987 |
AR226-0391
|
znqg6M5a1a90rkReEQvb6DBz |
3 |
|
The document reports on a biodegradation test of a mixture containing Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by Pace Incorporated for 3M, indicating that while some biodegradation occurred, the results are not representative of the test substance due to the mixture's composition and lack of methodological details.
|
1987 |
AR226-0395
|
x5dwXwvoNab1889QLV0v20eNJ |
3 |
|
The document discusses medical examinations conducted on Specialty Chemical employees, revealing no significant health issues related to liver and kidney function, but noting three cases of pleural thickening potentially linked to past asbestos exposure, and plans for further studies on the relationship between blood fluorine levels and health outcomes.
|
1987 |
AR226-0484
|
KJ371rEwj7bD31GgMbexwj9X2 |
6 |
|
The document reports on a biodegradation study of perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), conducted by 3M Company, which yielded invalid results due to discrepancies in data reporting and lack of sufficient characterization of the test substance.
|
1987 |
AR226-0495
|
6b6DM5Gm1p36YKzkDzM4zDXp9 |
5 |
|
The document reports on an Activated Sludge Respiration Inhibition Test conducted on PFOA ammonium salt (FC-126) produced by 3M, indicating varying levels of respiration inhibition at different concentrations, with a notable 18% inhibition observed at 100 mg/L.
|
1987 |
AR226-0510
|
EvrB8vx8gdaek3GxkD7kZD2gn |
7 |
|
The document reports on a Microtox toxicity test conducted by 3M Company on perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), determining a 30-minute EC50 value of 870 mg/L for the organism Photobacterium phosphoreum.
|
1987 |
AR226-0511
|
Vj4e0Kg1eBaZjy70Mex9xYoqo |
4 |
|
The document reports an acute toxicity test of perfluorooctanoic acid, ammonium salt (PFOA ammonium salt), conducted by 3M on Daphnia magna, revealing a 48-hour EC50 value of 221 mg/L.
|
1987 |
AR226-0512
|
gbQax7OKb4jE08KJwGNLj46vL |
4 |
|
This document reports on an acute toxicity test of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) conducted on the fish species Pimephales promelas, revealing total mortality at higher concentrations (320 mg/L and above) within 24 hours.
|
1987 |
AR226-0513
|
O1DxLOp3XpyOpbjndeE2vkJgj |
4 |
|
The document is an analytical report on FC-143 Lot 37, indicating that the substance, which is a perfluorinated compound, has been characterized and found to be stable and representative of commercial material, based on various pre and post-study analyses conducted by L. D. Winter for Riker.
|
1985 |
AR226-0466
|
xjMw8Ed4EybDOMmQnm6eR8vpb |
2 |
|
The document is an archived final report from 3M Company detailing a biodegradation study of perfluorooctanoic acid (PFOA, FX-1001) conducted in 1985, which concluded that no reliable conclusions could be drawn due to insufficient characterization of the test substance and lack of analytical confirmation.
|
1985 |
AR226-0494
|
LgkbdJV4d1ywrD0K2aZY0qdjq |
9 |
|
This document details an acute toxicity study of Perfluorooctanoic acid (PFOA) on the fish species Pimephales promelas, conducted in 1985, which involved a 96-hour exposure to varying concentrations of PFOA, revealing total mortality at the highest concentration tested.
|
1985 |
AR226-0509
|
a58oBVJ637edqmQew4vEZnGa |
5 |
|
The document reports on a solubility screening study conducted by 3M Company in 1984 for perfluorooctanesulfonyl fluoride (FX-8), indicating that it is slightly soluble in water with measured total organic carbon (TOC) values below 2 mg/L across various concentrations, although the study's reliability is questioned due to lack of actual concentration measurements and characterization of
|
1984 |
AR226-0374
|
OwBZ4Laok5doyXJYEZ4E2Zy1 |
6 |
|
The document reports on an activated sludge respiration inhibition test conducted by 3M Company on perfluorooctanesulfonyl fluoride (POSF), indicating that the substance showed no inhibitory effect on respiration at a concentration of 1000 mg/L over a 6.75-minute exposure.
|
1984 |
AR226-0375
|
q3QaO84vXm9bMDzDNZJ98M27E |
6 |
|
The document reports on an acute toxicity test of perfluorooctanesulfonyl fluoride (POSF) on the fish species Pimphales promelas, indicating that the 24, 48, and 96-hour LC50 values were all greater than 1000 mg/L, suggesting low toxicity at the tested concentrations.
|
1984 |
AR226-0376
|
3e7vOLxyooOapb3a01wGkyKE0 |
6 |
|
The document reports on a biodegradation study conducted by 3M Company on the test substance 2-(N-Ethylperfluorooctanesulfonamido)ethyl acrylate, indicating that it is not capable of readily biodegrading in aerobic environments, with significant biochemical oxygen demand (BOD) results.
|
1984 |
AR226-0411
|
93yLdx9576rodVNn3JNRoX6Oe |
8 |
|
The document reports on an acute toxicity study of the perfluorinated compound EtFOSEA (2-(N-Ethylperfluorooctanesulfonamido)ethyl acrylate) on fathead minnows (Pimephales promelas), concluding that the 96-hour LC50 is greater than 1000 mg/L, indicating low toxicity at the tested concentrations.
|
1984 |
AR226-0413
|
6JKa5MJ26JNzrLZZ9jq6794 |
4 |
|
The document reports on an activated sludge respiration inhibition test for the substance 2-(N-Ethylperfluorooctanesulfonamido)ethyl acrylate (B1228), conducted by 3M Company, which concluded that the substance exhibited no inhibitory effect on respiration at a concentration of 1000 mg/L after 6.65 minutes of exposure.
|
1984 |
AR226-0414
|
KJjqQV8bLDK28v216e6rjJ3Rr |
4 |
|
The document reports on an oral teratology study of T-3141CoC, sponsored by 3M Commercial Chemical Division, which found that the compound did not cause embryotoxicity or teratogenic effects in pregnant rabbits at doses up to 50 mg/kg/day, although the high dose group experienced significant weight loss.
|
1984 |
AR226-0465
|
vVrqknEGmJVG6OabjYaZgLgqb |
29 |
|
The document reports that inorganic fluoride test results from blood samples of personnel at 3M's Building 15, dating back to 1980 and tested up to November 1983, indicate no increased exposure to inorganic fluoride among the individuals tested.
|
1984 |
AR226-0482
|
dQbp8on7w69r3ykpDB1BORw89 |
3 |
|
The document discusses concerns regarding increasing blood fluorine levels among employees in Building 15, linked to the handling of organic fluorine compounds, and emphasizes the need for improved personal hygiene and engineering controls to mitigate exposure risks.
|
1984 |
AR226-0483
|
EdY2ovpBO2bkJ7EQv6NyZmMvV |
4 |
|
The document is a technical report summary from 3M Company regarding the identity and characterization of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), including remarks on its purity and the status of related studies.
|
1983 |
AR226-0365
|
v69NVYY4gm7kmMEBzg00rV12w |
36 |
|
The document reports on a primary skin irritation test conducted on T-3371, a substance evaluated for its potential to cause irreversible skin damage in female albino rabbits, resulting in moderate erythema, edema, and severe irritation without achieving the required endpoint.
|
1983 |
AR226-0424
|
bykLeO5peadpaDpvwq0LKXgd6 |
12 |
|
The document reports a study conducted by Riker Laboratories, Inc. on the excretion of carbon-14 from ammonium C-perfluorooctanoate in pregnant rats, finding that hormonal changes during pregnancy do not affect the elimination rate, with nearly all carbon-14 excreted via urine within 24 hours for both pregnant and nonpregnant rats.
|
1983 |
AR226-0458
|
8OQ9LNBLkY3BYkZO0djX1pLVa |
6 |
|
The document reports on a biodegradation test of a mixture containing Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M Company, indicating that some portion of the test sample biodegraded in aerobic environments, although the specific contributions of the test substance to the observed biodegradation values remain unclear.
|
1982 |
AR226-0392
|
LzX8neYpNL8GXZE4Nz5DQEJb |
7 |
|
The document is a letter from Dr. E. Marshall Jo to Dr. Franklin D. Griffith stating that FC143, a perfluorinated compound, has been adequately tested for developmental toxicity in pregnant rats and rabbits, concluding that it poses no hazard to the conceptus and recommending no further testing.
|
1982 |
AR226-0467
|
ykNazy317B2j5znBzddv20xrd |
1 |
|
The document discusses health evaluations conducted in 1981 for 264 employees at Chemolite, focusing on the assessment of health impacts related to fluorochemical exposure, with plans to compare testing data with blood fluorine levels and review health testing schedules.
|
1982 |
AR226-0480
|
kZL1EmyXRwXxLZg6YyMbpV5V |
1 |
|
The document details a chronic toxicity study of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) conducted by 3M on Daphnia magna, indicating that the test substance was a mixture with a purity of 96.5 - 100% and outlining the methodology and conditions of the study.
|
1982 |
AR226-0508
|
LGdo9XyKKnkkdYBMwbrpqLpb |
25 |
|
The document discusses a review of anatomical specimens related to a study on the effects of a test substance, indicating that previously reported abnormalities in fetal rat eyes were misidentified and that the evaluation process lacked proper coding and documentation.
|
1982 |
AR226-0530
|
XO4KkKXDaJmqqyRdL3DBre3EJ |
2 |
|
The document details an aquatic toxicity test of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol) on freshwater green algae (Selenastrum capricomutum), noting that the limited water solubility of the substance hindered a definitive determination of its toxicity.
|
1981 |
AR226-0361
|
o9570VvmDg36YDbOawE88BL37 |
14 |
|
The document reports on a study conducted by 3M Company assessing the activated sludge respiration inhibition of a mixture containing Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA), indicating no acute inhibitory effect at a concentration of 1000 mg/L, although the results may not accurately reflect the toxicity of the test substance due to the presence of organic solvents.
|
1981 |
AR226-0393
|
nNbXkq1VZkN42JmxLdzQM8k7a |
4 |
|
The document reports that the 96-hour LC50 for the fish species Pimephales promelas exposed to a mixture containing Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) was determined to be 863 mg/L, as submitted by 3M Company, although the toxicity results may not accurately reflect the test substance due to the presence of organic
|
1981 |
AR226-0394
|
zQYN1E95KwJE2xJ4noVw39VK7 |
5 |
|
This document is an amendment to a two-year oral toxicity and carcinogenicity study of fluorochemical FC-143 in rats conducted by Riker Laboratories, Inc. for 3M Company, correcting typographical errors in the presentation of clinical chemistry values without altering the interpretation of the data.
|
1981 |
AR226-0437
|
zoMaLQ7Np3451vLBonx06JLQ3 |
299 |
|
The document details a two-year oral (diet) toxicity and carcinogenicity study of fluorochemical FC-1A3 conducted by Riker Laboratories, Inc. for 3M Company on rats from April 1981 to May 1983.
|
1981 |
AR226-0439
|
QgBORJJj2LoZ8dKM6j1V2kqV4 |
320 |
|
The document details a two-year oral toxicity and carcinogenicity study of the fluorochemical FC-143 conducted by Riker Laboratories, Inc. for 3M Company, focusing on its effects in rats.
|
1981 |
AR226-0440
|
qd83on93DE3NV6bV31LRQzoVK |
314 |
|
The document reports on an oral teratology study of T-2998CoC, sponsored by 3M, which found that the compound did not exhibit embryotoxic or teratogenic effects in pregnant Sprague-Dawley rats, although it caused maternal toxicity at the highest dose.
|
1981 |
AR226-0463
|
k65wRZXoJ4v3LQw1v0gQqDmjV |
40 |
|
The document details an oral rangefinder study conducted by 3M Commercial Chemical Division to determine the upper dose level of T-3141CoC in pregnant rabbits for a subsequent teratology study, with dosing administered during specific gestational days.
|
1981 |
AR226-0464
|
N2n8ykq1ZvYwdZZDoBpe457yQ |
8 |
|
The document summarizes the results of health evaluations conducted in 1981 at the Chemolite plant, highlighting that 12% of employees had significant blood pressure elevations and elevated cholesterol levels, which may indicate potential health risks related to exposure to perfluorinated compounds.
|
1981 |
AR226-0481
|
VjpgzeME3MLY4poaa6b7VLgOg |
3 |
|
The document presents a calculation of the octanol/water partition coefficient for perfluorooctanoic acid, ammonium salt (FC-143), conducted by 3M Company, indicating a logP0w of approximately -0.9, which corresponds to a partition coefficient of about 0.126.
|
1981 |
AR226-0493
|
zzLoObL9M0XrRMnGG4NkdV21B |
2 |
|
This document details a 1981 acute static toxicity study of perfluorooctanoic acid ammonium salt (PFOA ammonium salt) on the aquatic plant species Selenastrum capricornutum, conducted by the USEPA, which involved various test concentrations and analytical monitoring of algal cell counts and dry weights.
|
1981 |
AR226-0506
|
k9m1QwR3Xm82RZB3a72oG0wYq |
20 |
|
The document reports on an acute toxicity test of Perfluorodecanesulfonate (PFDS) on the aquatic invertebrate Daphnia magna, conducted by 3M, indicating the test was completed in 1988 under GLP conditions, with specific details on test conditions and methodology.
|
1980 |
AR226-0389
|
KGGwaL7KqQ8Ba65xg1en23qXN |
18 |
|
This document reports on a study conducted by Riker Laboratories, Inc., a subsidiary of 3M, which found that after a single oral dose of the perfluorinated compound FC-143 (mean dose of 11.0 mg/kg) in male rats, at least 93% of the total carbon-14 was absorbed within 24 hours, with a plasma elimination half-life of
|
1980 |
AR226-0455
|
B5ZE00kdYprq2bNq10yvnwm8E |
15 |
|
The document is an update on a retrospective cohort mortality study conducted by University of Minnesota epidemiologists on employees at the 3M Chemolite Plant, which found no statistically significant differences in mortality rates, including prostate cancer deaths, compared to expected rates in the general population.
|
1980 |
AR226-0471
|
jZZZ37jvbwgdYzn1qd4Y0REO |
28 |
|
The document details a biodegradation study of perfluorooctanoic acid, ammonium salt (PFOA ammonium salt) conducted by 3M Company, indicating unreliable results due to insufficient characterization of the test substance and inconsistent data.
|
1980 |
AR226-0492
|
5oYgmY6oZXJme3E4KKvX8QR8 |
9 |
|
The document reports on a study conducted by 3M Company evaluating the acute toxicity of ammonium perfluorooctanoate (PFOA ammonium salt) on activated sludge respiration, concluding that it does not inhibit respiration at a concentration of 1000 mg/L with a limited contact time of 7 minutes.
|
1980 |
AR226-0505
|
9JxvqEmqGqVVQ5xbRrobv76mL |
4 |
|
The document details a 1979 study by 3M Company on the photodegradation of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol) in soil, concluding that no reliable results could be derived due to inadequate methodology and uncharacterized substance purity.
|
1979 |
AR226-0362
|
b5aa0nNE8pjDRG22gBeMRayjy |
12 |
|
The document contains comments by Professor Stephen A. Boyd on the 3M Technical Report regarding the analytical methodology and support for FM 3422, highlighting concerns about the octanol-water partition coefficient and its implications for predicting solubility in water.
|
1979 |
AR226-0366
|
embJmxnqMxrDoKBmY9LJwmJM |
3 |
|
This document details a 1979 bioaccumulation study of N-methylperfluorooctane sulfonamidoethanol (N-MeFOSE alcohol) in fish samples collected from the Tennessee River, highlighting the lack of standardized sampling procedures and the specific methods used for tissue analysis.
|
1979 |
AR226-0371
|
b9Ln4Jwnk3QXYZBdmep5jNgk |
36 |
|
The document reports on the analysis of serum samples from a Bio/Dynamics inhalation study of FC-143, focusing on the levels of organic and inorganic fluoride in male and female rats.
|
1979 |
AR226-0418
|
NEwQjYmNGxKjD9p1918G5z1aw |
2 |
|
The document reports on a 28-day percutaneous absorption study of the substance T-2618CoC conducted on albino rabbits at Riker Laboratories, Inc., which found dermal absorption but no significant adverse effects, although conclusions were limited due to the small sample size analyzed.
|
1979 |
AR226-0446
|
DMymg2r3xkbYz3ELnJX99NmDO |
16 |
|
The document details the synthesis and characterization of carbon-14 labeled FC-143, conducted by Riker Laboratories, Inc. for metabolism studies, reporting a specific activity of 0.507 ± 0.012 pCi/mg and a radiochemical purity of at least 98%.
|
1979 |
AR226-0456
|
OExrbgExjnVVEz2N9gBo790Qw |
17 |
|
The document reports on a study conducted by S. J. Gibson and J. D. Johnson in 1979, which found significant sex differences in the excretion rates of total carbon-14 from the perfluorinated compound FC-143 (ammonium salt of a perfluorinated carboxylic acid) in male and female rats, with females excreting nearly all of
|
1979 |
AR226-0457
|
NEJgOpGybG4bbYK2LQmZma7g |
20 |