|
The document reports on a developmental toxicity study of N-EtFOSE (N-Ethyl-Perfluoroocyanesulfonamido Ethanol) in pregnant rabbits, finding that while there were dose-related effects on body weight and food consumption at higher doses, the compound was not teratogenic as no malformations were observed in the fetuses.
|
1999 |
AR226-0274
|
4JxG3zZB5QvJX2mRyOX4qOgRe |
1 |
|
This interim report from 3M Environmental Laboratory details the analysis of perfluorobutanesulfonate (PFBS), perfluorohexanesulfonate (PFHS), and perfluorooctanesulfonate (PFOS) in various environmental samples from Northern Alabama's potable water systems as part of the 3M Decatur Monitoring Program.
|
1999 |
—
|
LZ989nBOqapv6dzgxDvqama5 |
123 |
|
The document outlines a protocol for a study on N-EtFOSE (N-Ethyl perfluorooctanesulfonamido ethanol) conducted by 3M's Corporate Toxicology Department, aimed at developing methods for collecting urine and bile specimens from treated rats to support an ongoing ADME study in Cynomolgus monkeys.
|
1999 |
AR226-0288
|
zzNvL23Q3Q8MOm259gR66XGpB |
7 |
|
This report evaluates the statistical quality of 12 data sources on serum perfluorooctanesulfonate (PFOS) levels in non-occupational human populations, finding that only pooled serum from U.S. blood banks was defensible for analysis, with a geometric mean PFOS blood level of 28.2 ppb.
|
1999 |
AR226-0036
|
ybzGXzkOYXxQZYqVE8vedNmd |
10 |
|
The document reports the vapor pressure of perfluorooctanesulfonate (PFOS), produced by 3M Company, as 3.31 x 10^-4 Pa at 20°C, determined using the Spinning Rotor Gauge method under GLP conditions.
|
1999 |
AR226-0047
|
81je0jDyjOMwojaN7jrbRgpa |
2 |
|
The document reports on a study conducted by Wildlife International, Ltd. for 3M Company to determine the n-octanol/water partition coefficient of perfluorooctanesulfonate (PFOS), which was ultimately deemed infeasible due to the formation of an inseparable emulsion during testing.
|
1999 |
AR226-0050
|
ydmV3r2ydwNGn3KQz3jwKEpE |
3 |
|
The document reports on a study conducted by Wildlife International Ltd. to determine the vapor pressure of PFOS using the spinning rotor gauge method, sponsored by 3M Corporation, and completed on May 5, 1999, while noting some deviations from Good Laboratory Practice Standards.
|
1999 |
AR226-0048
|
aDxeN3gbZGebbM778pd2aZbGy |
26 |
|
The document details a method developed by 3M's Environmental Laboratory to determine the air/water partition coefficient of perfluorooctanesulfonate (PFOS), indicating that the test substance was a white powder with unspecified purity and the experiment was completed in 1999 without following GLP standards.
|
1999 |
AR226-0051
|
J3vx6589XqXK85V7dg7BBLkae |
10 |
|
The document reports on a water solubility test for Perfluorooctanesulfonate (PFOS) conducted by 3M, finding an overall mean solubility concentration of 519 mg/L in NANOpure water.
|
1999 |
AR226-0054
|
71MX9kO44B1ZJxZyovQVL25ve |
22 |
|
The document reports on a study conducted by Wildlife International Ltd. for 3M Corporation to determine the water solubility of PFOS using the shake flask method, completed on May 3, 1999, with an amended report issued on April 26, 2000, and notes compliance with Good Laboratory Practice standards.
|
1999 |
AR226-0052
|
3Xx0EEzN7EyoBO5VoMYG2jgD |
35 |
|
The document presents a fugacity modeling study of perfluorooctanesulfonate (PFOS), conducted by Don Mackay, which concludes that PFOS tends to remain in water when released, with slow degradation and significant persistence in the environment.
|
1999 |
AR226-0060
|
85oNVbVqLbaE21z9Ywqj3GomK |
4 |
|
The document discusses the derivation of a draft lifetime Drinking Water Health Advisory (DWHA) for PFOS, based on a reference dose calculated using standard EPA methodology and a conservative uncertainty factor.
|
1999 |
AR226-0071
|
pBkok6KDNpkLGnL2dQyoOXGQE |
6 |
|
The document outlines a review of field sampling procedures conducted by Battelle during a city survey in Columbus, Georgia, as part of the Multi-City Human Exposure Assessment Study, focusing on the appropriateness of sampling techniques for fluorochemicals, including PFOA and PFOS.
|
1999 |
AR226-0072
|
v1gmMdx7428ZBRgy4pEzMbQrZ |
22 |
|
This is a field report from Battelle regarding a multi-city study conducted in Cleveland, Tennessee, and Decatur, Alabama, under Project Number N100672-01, focusing on the collection of samples for trace-level analysis of specific FC residuals.
|
1999 |
AR226-0073
|
LgxkewJ7YKGBOoqy0Oj6D2ObQ |
16 |
|
This is a final field report from Battelle (Project Number N100672-01) detailing the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, focusing on the collection of samples for trace-level analysis of FOSE-based fluorochemical residuals.
|
1999 |
AR226-0074
|
2G7YDyB9qO4Xd8oJdDdX24L7 |
16 |
|
The document is a final field report detailing the multi-city study conducted by Battelle in Mobile, Alabama, and Pensacola, Florida, focusing on the sampling and analysis of perfluorinated compounds, including PFOA and PFOS, as part of Project Number N100672-01.
|
1999 |
AR226-0075
|
O3mmmnVMXma5RjQ06BxqwLOyv |
17 |
|
The document outlines a study protocol by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA)
|
1999 |
AR226-0290
|
ba6dYJ9mabjp2rVqD2nMn1pe0 |
14 |
|
The document discusses concerns regarding the conclusion of a dietary toxicity study on N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE) conducted by Covance Laboratories, specifically questioning the determination of the no observable adverse effect level (NOAEL) and the biological significance of weight gain reductions at various dosage levels in rats.
|
1999 |
AR226-0301
|
3N3zO7mLL6wMEREV8mKV5BaD0 |
1 |
|
This document is an amendment to the Quality Assurance Project Plan for the Multi-City Study Sampling Task, prepared by Battelle, which outlines changes to sampling protocols, including the addition of labeling for 'Trip Blank' samples.
|
1999 |
AR226-0077
|
EdrZJm6RBzGKQDyvg7MMQMk4 |
23 |
|
This document details an acute toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the fish species Pimephales promelas, using a sample from 3M with a purity of 90.49%, following OECD and OPPTS guidelines, and completed in 2000.
|
1999 |
AR226-0082
|
37LG6w3rrkXjem70vdJgobpxn |
4 |
|
The document details a toxicity study of Perfluorooctanesulfonate (PFOS) conducted by 3M, which assessed its effects on the aquatic plant species Selenastrum capricornutum over a 96-hour exposure period, with a measured purity of 90.49%.
|
1999 |
AR226-0084
|
O3w4bNRw37BeaG8jmMpyxVorM |
6 |
|
This document details an acute toxicity study of perfluorooctanesulfonate (PFOS) on the aquatic invertebrate Daphnia magna, conducted under OECD guidelines, with a purity of 90.49% and results indicating the EC50 values calculated for PFOS exposure.
|
1999 |
AR226-0086
|
ByJJOvMdM356evMxvpjaxvXmJ |
4 |
|
The document details a study on the acute effects of perfluorooctanesulfonate (PFOS) on the shell growth of the Eastern oyster (Crassostrea virginica), using a sample from 3M with a purity of 90.49%, and outlines the methodology and statistical analysis used to determine the impact on shell growth over a 96-hour exposure period.
|
1999 |
AR226-0088
|
3wJvzz4rDyBve6N48MVkbDvJ |
4 |
|
This document reports on an acute toxicity study of perfluorooctanesulfonate (PFOS) conducted on the freshwater mussel species Unio complanatus, detailing the test conditions, methods, and analytical results from a sample sourced from 3M.
|
1999 |
AR226-0090
|
bBkmJGd1gkOoj7GnLgq9de9y3 |
4 |
|
The document details an OECD 209 activated sludge respiration inhibition test conducted on perfluorooctanesulfonate (PFOS) sourced from 3M, which was found to have a purity of 90.49% and involved assessing its impact on dissolved oxygen concentrations in activated sludge from a wastewater treatment facility.
|
1999 |
AR226-0092
|
3Qeg0y5aZLQ1KVkB2V873dgoy |
3 |
|
This document is an amended final report from Wildlife International Ltd. on a 96-hour shell deposition test conducted with the Eastern Oyster (Crassostrea virginica) to assess the effects of PFOS, sponsored by 3M Corporation, and it states compliance with Good Laboratory Practice standards while noting some exceptions in the characterization of the test substance.
|
1999 |
AR226-0089
|
npOzjNgaXknbXoN929OJwLMp8 |
56 |
|
This document is an amended final report of a 96-hour static acute toxicity test conducted by Wildlife International Ltd. on PFOS using the freshwater mussel (Unio complamatus), sponsored by 3M Corporation, and it outlines compliance with Good Laboratory Practice standards while noting exceptions in substance characterization and stability determination.
|
1999 |
AR226-0091
|
JJmomLXgrrDn7nG6mO76deKwK |
59 |
|
This document outlines a non-GLP study conducted by Wildlife International, Ltd. for 3M Corporation, focusing on the background screening of PFOS in selected avian and aquatic feed matrices.
|
1999 |
AR226-1030
|
kxwqwnaG5mxNv5Oe72EM2xkV |
25 |
|
The document details a study on the acute toxicity of perfluorooctanesulfonate (PFOS) to the saltwater mysid species Mysidopsis bahia, conducted by Wildlife International, Ltd., which determined the substance's purity to be 90.49% and involved a 96-hour exposure period to assess lethal concentration (LC50) values.
|
1999 |
AR226-0094
|
wgvXyayq5kLvwB0jbg9zpjM94 |
4 |
|
This document reports on a chronic toxicity study of perfluorooctanesulfonate (PFOS) conducted on early life stages of fish (Pimephales promelas) using a flow-through method, with a purity of 90.49% and significant statistical analysis performed to assess the effects of PFOS exposure over a 47-day period.
|
1999 |
AR226-0096
|
wggxnKLxKKybgwLa3KDLjpv14 |
5 |
|
This document details a chronic toxicity study of perfluorooctanesulfonate (PFOS) on freshwater invertebrates (Daphnia magna), conducted by Wildlife International, Ltd., which assessed survival, reproduction, and growth over a 21-day exposure period.
|
1999 |
AR226-0098
|
owG9V6zMowbewbkYBvdgKmdg |
6 |
|
The document details a chronic toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the saltwater mysid species Mysidopsis bahia, using a sample from 3M with a purity of 90.49%, and outlines the methods and statistical analyses employed to evaluate the effects of PFOS over a 35-day exposure period.
|
1999 |
AR226-0100
|
MJOy7n80RRY6Bx7oEwXOmDwLV |
7 |
|
The document is a final report on an early life-stage toxicity test of PFOS conducted with fathead minnows (Pimephales promelas) by Wildlife International Ltd. for 3M Corporation, completed on April 26, 2000, and compliant with Good Laboratory Practice standards.
|
1999 |
AR226-0097
|
3m65nOZdQZqw4292L1011pL3 |
88 |
|
The document is a final report on a semi-static life-cycle toxicity test of PFOS conducted with the cladoceran Daphnia magna, sponsored by 3M Corporation and compliant with Good Laboratory Practice standards.
|
1999 |
AR226-0099
|
MMkZb1zMjEdxbZN6epvgvB50j |
93 |
|
This document details a dietary acute study on the effects of perfluorooctanesulfonate (PFOS) on Northern bobwhite quail, conducted by Wildlife International Ltd., which involved testing the substance's concentration and stability in feed over a specified exposure period.
|
1999 |
AR226-0104
|
ypjrp1Gd56NkwjBdp4YkNOBLr |
9 |
|
The document is a final report on a flow-through life-cycle toxicity test of PFOS conducted with the saltwater mysid (Mysidopsis bahia) by Wildlife International, Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization.
|
1999 |
AR226-0101
|
kD2MNn8V78mkK9rx9BQLZj8XJ |
76 |
|
This document reports on a dietary LC50 study of PFOS conducted with mallards by Wildlife International Ltd. for 3M Corporation, completed on April 26, 2000, and outlines compliance with Good Laboratory Practice standards.
|
1999 |
AR226-0103
|
vBVbookBKm9OazkoEQVxjqpG9 |
89 |
|
The document is a final report by Covance Laboratories detailing a study on chromosomal aberrations in human whole blood lymphocytes exposed to PFOS, submitted to 3M Corporate Toxicology, and conducted in compliance with EPA regulations.
|
1999 |
AR226-0131
|
ORY65b0Yo9jzv0z1qVxnB4xK |
41 |
|
This document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA
|
1999 |
AR226-0332
|
jm1XYrym6rppKn0ezMEX56m1k |
14 |
|
The document reports the melting point determination of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol), indicating a melting point range of 55°C to 60°C, suggesting the presence of impurities in the sample.
|
1999 |
AR226-0347
|
2qBOjDqj9ED3pM3vKXDaJXbOg |
3 |
|
Empty document.
|
1999 |
AR226-0979
|
N29adZ719OZ8eM1MrV8Mj8Egb |
5 |
|
This document reports on a six-month study of PFOS effects on cynomolgus monkeys, detailing various health metrics such as TSH, cholesterol, HDL, LDL, and VLDL levels across different test groups.
|
1999 |
AR226-0979
|
Ex58nBVqmYqga0J6oO4xyQOqx |
11 |
|
This document is a second draft cell proliferation report detailing a 104-week dietary chronic toxicity and carcinogenicity study of perfluorooctane sulfonic acid potassium salt (PFOS) in rats, prepared by Pathology Associates International for 3M, and conducted in compliance with EPA Good Laboratory Practice regulations.
|
1999 |
AR226-0142
|
RpemneQDdrGom3BGKJqB808Yv |
26 |
|
The document discusses a pathology review of a six-month toxicity study on PFOS conducted on monkeys, concluding that the deaths of two high-dose male monkeys were likely related to compound toxicity, with one showing signs of acute pneumonia and the other exhibiting liver changes indicative of toxicity.
|
1999 |
AR226-0150
|
7Ro5NYGZLygb9zogORJzv6wEe |
2 |
|
The document is a pathology report detailing the results of a 26-week toxicity study on cynomolgus monkeys treated with perfluorooctane sulfonic acid potassium salt (PFOS), which found hepatocellular vacuolation and hypertrophy, primarily centrilobular, along with ultrastructural changes such as increased lipid droplets and glycogen in the liver.
|
1999 |
AR226-0149
|
rpVJdMomg28e2r63Zx4a9KoV7 |
60 |
|
This document outlines a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, aiming to assess its oral absorption, clearance, and metabolism to PFOS, conducted by 3M Chemicals Division under GLP conditions.
|
1999 |
AR226-0979
|
Gmbw0VQwkdG9DRpJz8X0bbwZ4 |
7 |
|
This document reports on a study by Kendall B. Wallace investigating the inhibitory effects of selected perfluorochemicals, including PFOA and PFOS, on mitochondrial fatty acid oxidation using rat liver mitochondria.
|
1999 |
AR226-0170
|
15V8qykqdQ6XKVDdEboBbpx9q |
4 |
|
The document is a field report detailing the multi-city study conducted by Battelle in Cleveland, Tennessee, and Decatur, Alabama, focusing on the sampling and analysis of perfluorinated compounds, including PFOA and PFOS, with results and observations from the study period in May 1999.
|
1999 |
AR226-0979
|
gbwNEmEYVdvkg5RJDYqwyzOkq |
16 |
|
The document discusses the derivation of a draft lifetime Drinking Water Health Advisory (DWHA) for PFOS, based on a reference dose calculated using EPA methodology and a conservative uncertainty factor.
|
1999 |
AR226-1030
|
g2qpqOX9N453YrbGxOo9VDeBG |
6 |
|
The document is an amendment to the Quality Assurance Project Plan for the Multi-City Study, detailing changes in sampling protocols and the addition of new laboratories for sample collection, which includes the implementation of a labeling system for PFOA and PFOS samples.
|
1999 |
AR226-1030
|
6w13L72217Q1RznY1KM6yEwZ4 |
3 |
|
This is a Quality Assurance Project Plan prepared by Battelle for the Empirical Human Exposure Assessment Multi-City Study Sampling Task, effective May 14, 1999.
|
1999 |
AR226-1030
|
10vG1eyV5odmxe50E4d493mdo |
52 |
|
This is a final field report prepared by Battelle for Project Number N100672-01, detailing the multi-city study activities conducted in Mobile, Alabama, and Pensacola, Florida, aimed at assessing environmental exposure to FC residuals.
|
1999 |
AR226-0979
|
wDQazkj2E5oVknGoKrKyVZYRD |
17 |
|
The document is a final field report detailing the sampling activities conducted by Battelle in Columbus, Georgia, and Port St. Lucie, Florida, aimed at collecting representative samples for trace-level analysis of perfluorinated compounds, including PFOA and PFOS.
|
1999 |
AR226-0979
|
bv9MkZRN1mVGqr9yn5eQ5yYO |
16 |
|
This document outlines a pharmacokinetic study protocol by 3M to assess the oral absorption, clearance, and biological persistence of perfluorooctane sulfonyl fluoride (POSF) in rats, aiming to understand its metabolism to perfluorooctane sulfonate (PFOS) for risk characterization purposes.
|
1999 |
AR226-0180
|
vENKmMxexLMrQY8p9oDMr92m |
6 |
|
This document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater alga Anabaena flos-aquae, to be conducted by Wildlife International, Ltd. for 3M Corporation, following EPA guidelines.
|
1999 |
AR226-0186
|
e5YwBk0xnVLx9QJEjwKOewRR4 |
16 |
|
This document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater diatom Navicula pelliculosa, to be conducted by Wildlife International, Ltd. for 3M Corporation.
|
1999 |
AR226-0187
|
O15ne4DQLoK8ZJG4XenDe3B6e |
17 |
|
This document outlines a protocol for a 96-hour toxicity test of PFOS using the marine diatom Skeletonema costatum, sponsored by 3M Corporation and conducted by Wildlife International, Ltd.
|
1999 |
AR226-0188
|
emZz48oxBQD8Kb9wZOMo58x79 |
17 |
|
The document outlines a protocol for a seven-day toxicity test of PFOS using duckweed (Lemna gibba G3), to be conducted by Wildlife International, Ltd. for 3M Corporation, following EPA guidelines.
|
1999 |
AR226-0189
|
7R8DwaQ6Jq6bGr9JMVqGOz0Na |
18 |
|
This document is an amendment to the Quality Assurance Project Plan for the Multi-City Study, detailing changes in sampling methods for fish, bulk water, and microlayer samples related to PFOA/PFOS exposure assessment.
|
1999 |
AR226-1030
|
0wnRnEao39dw9pJmYRvqERrb |
17 |
|
The document outlines a protocol for a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, sponsored by 3M Specialty Chemicals Division, to assess its oral absorption, clearance, and metabolism to PFOS for risk characterization.
|
1999 |
AR226-0209
|
JNk1LOxmny2127E4LvjqxdLBe |
6 |
|
The document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA
|
1999 |
AR226-0215
|
bBvMkm1xZn4qOQaaw3KEQLm0y |
14 |
|
This is a field report prepared by Battelle for Project N100672-01, detailing sampling activities in Cleveland, Tennessee, and Decatur, Alabama, aimed at analyzing trace-level FC residuals and assessing environmental dispersion and human exposure.
|
1999 |
AR226-1030
|
Lg2OObmLkvywpEZ4Mm3EXL5kz |
16 |
|
This is a field report from Battelle detailing a multi-city study conducted in Mobile, Alabama, and Pensacola, Florida, under Project Number N100672-01, focusing on the collection of samples for trace-level analysis of FC residuals to assess environmental dispersion and human exposure.
|
1999 |
AR226-1030
|
gbwNenROByp61qkrEXKGr5oLL |
15 |
|
The document outlines a review of the sampling and handling techniques used by Battelle during a city survey in Columbus, Georgia, as part of the Multi-City Human Exposure Assessment Study, focusing on various environmental sources including air, drinking water, wastewater, and landfill leachate, with an emphasis on the appropriateness of methods for detecting fluorochemicals.
|
1999 |
AR226-1030
|
LKkZQ1o5yJ57DYMR1BkggVoJd |
22 |
|
This document is an amendment to the Quality Assurance Project Plan for the Multi-City Study, detailing changes in sample labeling and collection procedures, including the addition of samples for two additional laboratories at the client's request.
|
1999 |
AR226-1030
|
aBMQm3rxYxoQggzo2YYg0qQ2a |
3 |
|
The document outlines a review of the sampling and handling techniques used by Battelle during the Columbus, Georgia city survey as part of the Multi-City Human Exposure Assessment Study, focusing on various environmental sources including urban air, drinking water, wastewater, and landfill leachate in relation to fluorochemical characteristics.
|
1999 |
AR226-1030
|
byw20EQp39RVORyNXoDKawgEO |
22 |
|
This is a Battelle field report for the Multi-City Study (Project Number N100672-01) detailing sampling activities in Cleveland, Tennessee, and Decatur, Alabama, aimed at analyzing trace-level FC residuals and assessing environmental dispersion and human exposure.
|
1999 |
AR226-1030
|
QMLeZRDEyjaOk53YXdYKm6OGv |
16 |
|
This is a field report from Battelle (Project Number N100672-01) detailing the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, focusing on the collection of samples for trace-level analysis of FOSE-based fluorochemical residuals to assess environmental dispersion and human exposure.
|
1999 |
AR226-1030
|
bB12ZLR9rLaJmGzDjqb7xeBoy |
15 |
|
This is a field report prepared by Battelle Marine Sciences Laboratory for Project Number 31565, detailing the collection of finfish, microlayer, and bulk water samples in Cleveland, Tennessee, Decatur, Alabama, and Columbus, Georgia, from August 9 to August 12, 1999, to analyze environmental dispersion of FOSE-based fluorochemical residuals.
|
1999 |
AR226-1030
|
3J0R8gmLkNz02egK6zMLXraaa |
28 |
|
The document discusses the derivation of a draft lifetime Drinking Water Health Advisory (DWHA) for PFOS, based on a reference dose calculated using standard EPA methodology and a conservative uncertainty factor.
|
1999 |
AR226-1030
|
VK2qeo4aznzzJjD6Xoj3JOG9q |
6 |
|
This is a field report from Battelle detailing activities conducted in Mobile, Alabama, and Pensacola, Florida, for Project Number N100672-01, focusing on the collection of samples for trace-level analysis of FC residuals to assess environmental dispersion and human exposure.
|
1999 |
AR226-1030
|
ypm84jKoLgLYgLnvpMR5bZxr |
15 |
|
This is a field report prepared by Battelle Marine Sciences Laboratory for Project Number 31565, detailing the collection of finfish, micro-layer, and bulk water samples in Mobile, Alabama, Pensacola, Florida, and Port St. Lucie, Florida, for trace-level analysis of FOSE-based fluorochemical residuals.
|
1999 |
AR226-1030
|
QX6gGpM4BRMkKkLre5BVqpJ34 |
32 |
|
This document is an amendment to the Quality Assurance Project Plan for the Multi-City Study, detailing changes in sampling methods for fish, bulk water, and microlayer samples related to PFOA/PFOS exposure assessment.
|
1999 |
AR226-1030
|
2Ry45Lxz0J7Gwgq53k3z8RGdg |
17 |
|
This is a Quality Assurance Project Plan prepared by Battelle for the Multi-City Study Sampling Task, effective May 14, 1999, detailing project management and quality assurance protocols.
|
1999 |
AR226-1030
|
65p2aYpdM4Zox92ajBnqpb0x6 |
52 |
|
The document is a review letter from Covance Laboratories regarding the mouse lymphoma cell mutation testing of 3M product T-6906, indicating that the study was technically inadequate and recommending a repeat of the assay to validly assess the mutagenic activity of the compound.
|
1999 |
AR226-0254
|
6bwwwrrbogBgN9mmnXqq9ZD46 |
3 |
|
This document outlines a non-GLP study conducted by Wildlife International, Ltd. for 3M Corporation, focusing on a background screen for PFOS in selected avian and aquatic feed matrices.
|
1999 |
AR226-1030
|
e5LqzJ194KDpZzGz7Jad3YXyp |
25 |
|
The document details a revised dietary acute study on the effects of perfluorooctanesulfonate (PFOS) on northern bobwhite quail, including tissue analysis and methods for testing purity and concentration of the substance sourced from 3M.
|
1999 |
AR226-1030
|
byg6rbj8JwVoQ8ModX89YzeQy |
9 |
|
The document details a revised study on the acute toxicity of perfluorooctanesulfonate (PFOS) to the freshwater mussel species Unio complamatus, conducted by 3M, which included tissue analysis and determined the substance's purity to be 90.49%.
|
1999 |
AR226-1030
|
Ed9VOByKveQmze30y5dMaNak0 |
5 |
|
3M is submitting a supplemental notice to the EPA regarding studies on the detection of perfluorooctanesulfonate (PFOS) in tissue samples from various animal species, highlighting initial screening data on PFOS distribution in biota using high-performance liquid chromatography-tandem mass spectrometry.
|
1999 |
AR226-0541
|
RjXdE1Zdoxrm9xDww17QZmDmB |
4 |
|
The document is a correspondence from Larry R. Zobel of 3M to the EPA, summarizing findings from rat teratology studies on 3M fluorochemicals, indicating that while FC-95 did not cause skeletal abnormalities, a mixture of perfluoroethanol derivatives resulted in significant fetal malformations, including cleft palates and kidney issues at high doses.
|
1999 |
AR226-0542
|
waqQ1GxzqQY883gZv6GV26E |
5 |
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3M is sending the EPA two papers on perfluorooctane sulfonate (PFOS) and organic fluorochemistry, along with a note about a forthcoming exposure assessment, to facilitate a discussion on these topics.
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1999 |
AR226-0546
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pDG43dDnoLKbRpEpKD2gdwbB |
1 |
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The document discusses the science of organic fluorochemistry, detailing 3M Company's history and methods in synthesizing perfluorinated compounds through the Simons Electro-Chemical Fluorination process.
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1999 |
AR226-0547
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bOXJNyv3kyO03EEVrqOrd6X3 |
12 |
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3M submitted an overview paper to the EPA detailing the manufacture, use, distribution, and environmental release of sulfonyl-based fluorochemicals, including PFOS, along with a preliminary life-cycle assessment of exposure pathways and ongoing stewardship initiatives.
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1999 |
AR226-0549
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6EBEyLVGN88oEbkrmX8d6V1o |
2 |
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This document by 3M summarizes the biological effects, health risks, and future research plans related to perfluorooctane sulfonate (PFOS), highlighting its presence in human serum samples at levels of tens of parts per billion.
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1999 |
AR226-0548
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aJV8p8nvjBJag7K8LRqbMwVa9 |
135 |
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This document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater alga Anabaena flos-aquae, sponsored by 3M Corporation and conducted by Wildlife International, Ltd.
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1999 |
AR226-0186
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yp5oZ784nZ25kDM1q03gOXQp3 |
16 |
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The document outlines a protocol for a 96-hour toxicity test of PFOS using the freshwater diatom Navicula pelliculosa, to be conducted by Wildlife International, Ltd. for 3M Corporation.
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1999 |
AR226-0187
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gD7OXJXZJ91ZvbjRb4a8L8LKN |
17 |
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This document outlines a protocol for a 96-hour toxicity test of PFOS using the marine diatom Skeletonema costatum, sponsored by 3M Corporation and conducted by Wildlife International, Ltd.
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1999 |
AR226-0188
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ykVqmZE5yM31a5DOyrynZyzQE |
17 |
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The document outlines a protocol for a seven-day toxicity test of PFOS using duckweed (Lemna gibba G3) conducted by Wildlife International, Ltd. for 3M Corporation, following EPA guidelines to assess ecological effects.
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1999 |
AR226-0189
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dDMbJkn4zG4za3v0xw6yaa2R5 |
18 |
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This document is a report prepared by 3M Company on May 26, 1999, providing an overview of the use, distribution, and environmental release of sulfonyl-based fluorochemicals, intended to inform exposure assessment and product stewardship initiatives.
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1999 |
AR226-0550
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pBxQkBGD7DyRMrBMDdErVaz0E |
350 |
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The document outlines a protocol for a pharmacokinetic study of perfluorooctane sulfonyl fluoride (POSF) in male Sprague Dawley rats, sponsored by 3M, to assess its oral absorption, clearance, and metabolism to perfluorooctane sulfonate (PFOS) for risk characterization purposes.
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1999 |
AR226-0209
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1ywqr0EmbJB61dV7v5Q0NrkVm |
6 |
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The document outlines a study protocol sponsored by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA
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1999 |
AR226-0215
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km1gaYBYJxQbDpxQBeO9REZnV |
14 |
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This document is a final report on a pharmacokinetic study of PFOS conducted in rats, detailing the study's methods, results, and compliance with regulatory standards.
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1999 |
AR226-0565
|
VJBVmBvvDrNL2wgObQ1zJRGXp |
172 |
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This document outlines the protocol for a pharmacokinetic recovery study of potassium perfluorooctane sulfonate (PFOS) in rats, conducted by 3M Environmental Technology and Safety Services to determine PFOS levels in liver and serum specimens.
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1999 |
AR226-0566
|
NGdeXkz65Q7zYMQMb9brromMp |
25 |
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This document outlines a protocol for an oral pharmacokinetic study of potassium perfluorooctane sulfonate (PFOS) in rats, sponsored by 3M, aimed at determining PFOS levels in liver and serum specimens.
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1999 |
AR226-0567
|
YjGNyJ72QbbMJ4Kv1nRbJYYk8 |
24 |
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This document is the final report of a pharmacokinetic recovery study of PFOS conducted in rats, detailing the study's methods, results, and conclusions.
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1999 |
AR226-0568
|
Z4JnMnmO6z2wDBVgVzeQyRbYY |
160 |
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This document is a final report on a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of PFOS conducted in rats, detailing the study's methods, results, and conclusions.
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1999 |
AR226-0563
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aJz93wv3rdONV9X2k8VvY3XMb |
645 |
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The document summarizes a two-generation reproduction study of PFOS (Perfluorooctanesulfonate) conducted on rats, which assessed the effects of various dose levels on fertility, development, and postnatal reproduction, with findings indicating no deaths in the Fo generation animals.
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1999 |
AR226-0569
|
XQgzBBGgvemZn700BKppae3G |
11 |
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This analytical laboratory report details the determination of the presence and concentration of Perfluorooctanesulfonate (PFOS) in the serum of Sprague-Dawley rats exposed to potassium perfluorooctanesulfonate via gavage, conducted by 3M Environmental Laboratory.
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1999 |
AR226-0570
|
EqMozRYwLaYJ2r7qqejMB4Y6n |
113 |
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The document is a pathology report detailing an ancillary study on the pharmacokinetics of PFOS in CRL:CDBR VAF/Plus rats, indicating no significant ultrastructural differences in liver and lung tissues between treated and control groups.
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1999 |
AR226-0572
|
JvE81EJ73DJd9jnRRz4OooJ12 |
74 |
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The document is a final report for an oral (gavage) cross-fostering study of PFOS in rats, conducted under study number T-6295.13, detailing the methods, results, and conclusions of the research.
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1999 |
AR226-0571
|
wgLo66D4wYRpp2rjKwzZ4OabJ |
257 |