Pre-1970

Documents dated before 1970.

Page 1 of 1 — 91 documents
Title / Summary Year AR226 Docket Hash ID Pages
Unreadable document. 1969 AR226-1969 99jwyVrXdeO3VnLjO5kYpRGop 4
Unreadable document. 1968 AR226-1968 vy692dyO8LO3Za2wZnR3zZnzZ 4
The document details an acute toxicity test on a mixture containing perfluorooctanesulfonate (PFOS) using eastern oysters (Crassostrea virginica), indicating that the test sample, identified as FC-206, consists of 0.67% PFOS among other components, and outlines the methodology and conditions of the bioassay conducted. 1967 AR226-0786 g2Rq3d7zqEZ8Edqoz1JDOjxX3 8
Unreadable document. 1967 AR226-1967 rp8yzXRw6YaozZvj0Q1y4nJNr 3
The document details an acute toxicity test of a mixture containing perfluorooctanesulfonate (PFOS) on eastern oyster embryos (Crassostrea virginica), using a Pacific Oyster Bioassay method to assess the impact of the test substance, identified as FC-206, which comprises 0.67% PFOS among other components. 1967 AR226-0786 1Qka5x2JOdBryvnkmvekz54Ya 8
The document outlines the status and program related to C-8 (PFOS) control at DuPont, including communication meetings, epidemiology studies, and findings indicating no conclusive evidence of health problems among workers exposed to C-8. 1965 AR226-1965 MGNDo4NQ6Qx3zdRjzN0BZX2yL 36
The document reports that a skin irritation and sensitization study conducted by Haskell Laboratory on fabrics treated with a proposed fabric softener, which contained PFOA, showed no adverse reactions in 204 subjects, indicating that the commercial use of the softener would not cause contact dermatitis. 1965 AR226-2823 LKeYy4vmbg0pD2y0QX6N5mjk5 1
This document outlines a 90-day feeding study on a compound sponsored by E. I. duPont de Nemours and Company, detailing methods and results related to the health effects observed in Beagle dogs. 1965 AR226-2825 aBzQ2073wexjZ3Dy1vrGNQ9M 57
The document reports on a 90-day feeding study conducted by the International Research and Development Corporation, sponsored by E.I. duPont de Nemours and Company, which found no adverse effects on body weight gain or significant hematologic and biochemical changes in rats fed diets containing varying levels of a perfluorinated compound. 1965 AR226-2824 2RxxLkQerxGkem1Bjkam7gV4R 90
The document outlines a protocol for an exploratory in-vitro absorption study of perfluorooctylsulfonate (PFOS) and ammonium perfluorooctanoate (PFOA) using the SkinEthic Reconstituted Epidermis Model, conducted by 3M's Corporate Toxicology Department. 1962 AR226-0182 gb6gRG7rzy2oY2nQ2OXLVem3V 6
The document outlines a protocol for an exploratory in-vitro absorption study of perfluorooctylsulfonate and ammonium perfluorooctanoate, conducted by 3M's Corporate Toxicology Department to assess skin absorption using the SkinEthic Reconstituted Epidermis Model. 1962 AR226-0182 pBqGoy0rwZnLZJpoKwoOR1oBX 6
This document reports on a study conducted by 3M to investigate the mechanism of toxicity of Perfluorooctanesulfonate (PFOS) in adult rats, focusing on its potential to damage muscle mitochondria and cause conditions like rhabdomyolysis and lactic acidosis at high exposure levels. 1962 AR226-1724 ppyoKX7VOMZa2MdjgJ9q539mj 14
The document reports on a study conducted by 3M to investigate the mechanism of toxicity in adult rats exposed to high levels of Perfluorooctanesulfonate (PFOS), specifically examining its potential to damage muscle mitochondria and lead to conditions like rhabdomyolysis and lactic acidosis. 1962 AR226-1781 jJyxDK8kbzpjmw2BXbYx51v9 14
The document discusses the covariant analysis for study 418-020 related to sexual maturation in rats exposed to a test substance, with a focus on how gestational age and body weight affect maturation outcomes, potentially relevant for understanding the effects of PFOA or PFOS. 1962 AR226-1781 6w4bE9nXz0OEEN0mgVV6qxRa3 22
A retrospective cohort mortality study conducted by University of Minnesota epidemiologists on 3M employees at the Decatur, Alabama plant found no significantly elevated standardized mortality ratios (SMRs) for those exposed to perfluorinated compounds, with recommendations for an updated study to include additional mortality data. 1961 AR226-0032 EqDBZrpLYDGrpqO2x6azbY8Eg 50
A mortality study of employees at the 3M plant in Decatur, Alabama, conducted by University of Minnesota epidemiologists, found no significantly elevated standardized mortality ratios (SMRs) among workers exposed to perfluorinated compounds, with recommendations for an updated study to include additional mortality data. 1961 AR226-0032 LKDKn5EdLgvnxXwmB6r74Mj5 50
The document is a letter from 3M's Dr. William Weppner to EPA's Charles M. Auer, outlining the agenda for a meeting on December 14, 1998, to discuss the TSCA 8(e) filing regarding the presence of perfluorooctane sulfonate (PFOS) in blood samples from the general population. 1958 AR226-0622 qaOX6wYVmkkDp14DN5banDY5M 1
3M is submitting additional pathology reviews related to perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS) to the EPA as part of their ongoing dialogue regarding perfluorochemicals. 1958 AR226-1915 dn00YymvDjERyQDg4ZrBBpgLR 1
The document is a letter from 3M's Dr. William Weppner to EPA's Charles M. Auer, outlining the agenda for a meeting on December 14, 1998, to discuss the TSCA 8(e) filing regarding the presence of perfluorooctane sulfonate (PFOS) in blood samples from the general population. 1958 AR226-0622 NGNJa0Mvdb6pBq085nZYVp6qy 1
3M submitted pharmacokinetic studies on perfluorobutane carboxylate (PFBA), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA) to the EPA as part of their ongoing dialogue regarding perfluorochemicals. 1958 AR226-3925 pBxeKoO3X10Y562rM53JgxpeB 2
This document reports on a study evaluating the incidence of myocardial infarction among male employees at the Washington Works Plant from 1956 to 1973, revealing 61 observed cases and comparing them to expected rates based on Du Pont Company statistics. 1956 AR226-1496 xz68NroLV7vakkEKny8GGazX0 8
This document is the final report of a case-control study investigating leukemia at the Washington Works site, sponsored by DuPont Co. and Polymer Products, with a focus on exposure assessment related to perfluorinated compounds. 1953 AR226-1308 82g4qR1grJGz1B3ddoGVmDNLy 13
This document appears to be an emissions inventory report detailing surfactant emissions from various stacks, including their dimensions, flow rates, and temperatures, along with permitted and actual emissions data. 1953 AR226-2161 daMed2e0EQGLVq4jo7QB70K8q 3
This document appears to be a detailed emissions report summarizing stack parameters, flow rates, and estimated emissions for various vents associated with a semiworks application, including specific measurements such as diameter, height, and temperature. 1953 AR226-2168 eNQkbDR2VEbQz4rNrvgR3mNy 5
This document appears to be a detailed emissions report outlining stack specifications, flow rates, and permitted versus actual emissions for various units, including multiple stack identifiers and measurements for a facility's air emissions compliance. 1953 AR226-2170 zE84JYoXd6r5EaQR5kKxL3Dz 1
This document appears to be an emissions inventory report detailing permitted and actual emissions for various stack vents, including specific measurements such as stack diameter, height, flow velocity, and temperature, along with associated particulate matter fractions. 1953 AR226-2176 rZd6QvJkjv3DERGdr6YwG8Zq 3
This document appears to be a data sheet detailing stack emissions and surfactant rates for various vents, including actual and permitted emission levels, stack dimensions, and flow velocities, likely related to a semiworks application. 1953 AR226-2200 nzgvOZr5m4QpbKMzL44Zbjq1 2
This document appears to be a data report detailing emissions and operational parameters for various permit vent IDs, including stack dimensions, flow velocities, and estimated emissions for a semiworks application. 1953 AR226-2213 G6V91NmBXJ39OVwO27vrJ1oMV 4
This document contains emission data and parameters related to a permit application (Permit Number 1881253DA) for a facility with multiple vent IDs, detailing flow rates, velocities, and potential emissions. 1953 AR226-2222 QjEReVxd5jw9o9eaeOVnd798 5
The document provides production and emission data for perfluorinated compounds, specifically detailing annual production figures and emission rates from various sources in 2003, with a total emission of 11,154,000 pounds. 1953 AR226-2261 x1216aM715az0OOOzE347GRv1 2
This document includes various permit and emission data related to stack emissions for multiple units, with specific reference to surfactant rates and particulate emissions as part of an Air Emissions Inventory. 1953 AR226-2298 9kZp3NRMOpw6EZnR0drgeQw7 7
This document contains emissions data and permit information for various vents associated with a semiworks application, detailing stack dimensions, flow rates, and emission rates for specific substances. 1953 AR226-2299 2RMQEk2axb711zkXb0Ox2ak2g 5
This document appears to be a series of laboratory data entries related to air quality measurements, specifically focusing on PFOA levels over several years, but the content is largely obscured and difficult to interpret. 1950 AR226-2002 XRmGqjDDXvmo66X3LM1Nbk5Od 11
The document provides background information on ammonium perfluorooctanoate (C-8), detailing its use as a dispersing agent in polymerization for Teflon and other fluoropolymers, its environmental release pathways, and contamination findings at the Washington Works site, including groundwater and soil contamination. 1950 AR226-2412 6R3DOZzKrKyrdo9xXYrLJk3Mo 9
The document outlines Dupont Fluoroproducts' history of using Ammonium Perfluorooctanoate (C-8) since the 1950s, detailing storage, handling practices, a past spill incident, and the company's commitment to reducing C-8 emissions to very low levels. 1950 AR226-2470 a4n8B0M0kBp2Eyj5v2RK1ej2b 2
The document reports on a retrospective cohort mortality study of employees at the Chemolite Plant in Cottage Grove, Minnesota, conducted by Schuman and Mandel, which found no significant mortality findings related to perfluorooctanoic acid (PFOA) among the 3,688 workers studied, and recommends continued monitoring of the cohort's vital status. 1947 AR226-0470 ppRGXZEbK5z7DVydvq8YQy4mj 16
The document reports on a retrospective cohort mortality study of employees at the Chemolite Plant in Cottage Grove, Minnesota, conducted by Schuman and Mandel, which found no significant mortality findings related to perfluorooctanoic acid (PFOA) among the 3,688 workers studied. 1947 AR226-0470 85xGDjrE63bjXM5jq6oEwr1Ek 16
The document is a final report detailing an extended laboratory study on the atmospheric degradation of the fluorinated alcohol C6F13CH2CH2OH and its aldehyde product C6F13CHO, conducted by CNRS-LCSR and RAND Corporation, which aims to understand the photolysis rates and environmental impact of these compounds. 1944 AR226-1944 DD2GGqg5EbGBNOOker1GoBwqQ 16
The document details an extended laboratory study conducted by Professor Georges Le Bras and colleagues on the photolysis rate of perfluorinated aldehydes, aiming to reduce or eliminate the production of corresponding perfluorocarboxylic acids under low NOx conditions, using solar radiation experiments at the EUPHORE facility in Valencia, Spain. 1943 AR226-1943 9Jne4dBoXG5znjRqzpEZxdZ17 7
The document is a submission from the Telomer Research Program, representing companies including DuPont, to the EPA, providing a final report and study summary on the atmospheric degradation of fluorinated alcohols, which is related to PFOA and PFOS research. 1942 AR226-1942 VembBGezvKLGpjo5EK1qjEEq 1
the maternal toxicity observed at 500 mg/kg/day of 8-2 Telomer B Alcohol, as indicated by maternal mortality, decreased body weights, and increased clinical toxicity signs in the study conducted by E.I. du Pont de Nemours and Company. 1940 AR226-1940 KRogqqVRe7x7511Vvkz6BDyp0 15
The document reports on a developmental toxicity study of 8-2 Telomer B Alcohol conducted by DuPont, following EPA and OECD guidelines, to assess its effects on rats. 1939 AR226-1939 gDorZ88LEeEgoGrE13Vx1NmGN 156
The document is an analytical report from Severn Trent Laboratories for Weston Solutions, Inc. regarding a confidential investigation in Decatur, detailing wet chemistry data and sample analysis related to perfluorinated compounds. 1938 91QQGGzKweLzEB38ow2w1VeB6 90
The document is an analytical report from Severn Trent Laboratories for Weston Solutions, Inc. regarding a confidential investigation in Decatur, which includes wet chemistry data and sample information related to perfluorinated compounds. 1938 AR226-3828 V3kx1Z7E48r5OyqoxxBj4dvyj 90
The document reports that a primary skin irritation test conducted on T-3493 at Riker Laboratories, Inc. found it to be non-irritating to the skin of female albino rabbits, with no signs of erythema or edema observed. 1934 AR226-0305 3JK5JwZDgeJNkEN3G91Oxky20 10
The document reports that a primary skin irritation test conducted on T-3493 at Riker Laboratories, Inc. found it to be non-irritating to the skin of female albino rabbits, with no signs of erythema or edema observed. 1934 AR226-0305 jBrBZao8qa6B5RbMKEEzaoGJy 10
This document is a revised analytical report from Exygen Research detailing the analysis of perfluorooctanoic acid (PFOA) and perfluorooctanesulfonate (PFOS) in water samples from Oakdale Municipality, requested by Gary A. Rohenstein of 3M Company, with no changes to the analytical results. 1933 AR226-1933 o9r15jKYbJY4wzBDqb8mOpawo 10
The document provides emission information and potential-to-emit calculations for various vents associated with semiworks applications, specifically focusing on C-8 (which includes perfluorinated compounds like PFOA) and detailing the expected distribution and particulate emissions from the sampling apparatus. 1933 AR226-2226 5Dy6J8EKdjE3bpJeqgo2VajV4 4
This document reports the analysis of blood samples for perfluorooctanoate (PFOA) conducted by DuPont, detailing the concentrations found in various samples collected in December 1981. 1932 AR226-1611 06RjE1Zm4aGpggeMDV7R5n2kJ 3
This document appears to be a data report from an unspecified laboratory detailing analytical results, including concentration measurements and instrument conditions, related to a study conducted on March 19, 1995. 1932 AR226-2075 dYnNQe9BgXN5rXjZoLJByqBM5 2
The document is a study report by E. I. du Pont de Nemours and Company detailing a static acute 96-hour LC50 test of the substance H-19,173 on fathead minnows (Pimephales promelas), conducted under Good Laboratory Practice guidelines. 1932 AR226-2978 dgnn10MyeEKGM5NKygLDZ1eB 14
The document is a response from XENOS regarding FDA inquiries about a toxicity study on the chemical F n -3 9 2 4 conducted by RIKER Laboratories, addressing liver changes in rats and confirming that the original findings remain unchanged despite the FDA's request for additional data. 1931 AR226-0263 8RB49MjNRdMYXQeDgaBj7mdrK 11
The document discusses the response of XENOS to FDA inquiries regarding a toxicity study of the chemical F n-3 9 2 4 conducted by RIKER Laboratories, specifically addressing liver changes observed in rats and confirming that the original findings remain unchanged. 1931 AR226-0263 2ZBM0NV1GOgzM9Da82RDVvog 11
The document reports on a study conducted by Riker Laboratories, a subsidiary of 3M, which found that cholestyramine treatment significantly enhanced the elimination of carbon-14 labeled FC-95 and FC-143 in male rats, reducing retention in liver, plasma, and red blood cells while increasing fecal excretion. 1930 AR226-0459 pBdB7ayjRQaEzXxNXEm3bj5qB 29
The document reports that cholestyramine treatment significantly enhanced the elimination of carbon-14 labeled FC-95 and FC-143 in male rats, with notable reductions in liver, plasma, and red blood cell concentrations and increased fecal excretion compared to control groups. 1930 AR226-0459 5D24KMdnBNJx2rEQ0LoLLw7V 29
The document is a correspondence from the Association of Plastics Manufacturers in Europe (APME) to the EPA, enclosing final reports on oral toxicity studies of ammonium perfluorooctanoate (APFO) in monkeys conducted by Covance Laboratories and analytical work by 3M, as part of the administrative record AR-226. 1928 AR226-1052 KJXYD3GnJqLa6R3xyzXODk57N 2
The document reports the results of an acute toxicity test conducted by 3M Company on the perfluorinated compound Perfluorooctanesulfonylamido(ethyl)acetate (FC-109-X), finding a 96-hour LC50 value of 57 mg/L for fathead minnows (Pimephales promelas) and a no observed effect level of less than 1923 AR226-0396 XRK6rZYnNVRkYpZN3pqaD56GJ 22
The document presents the results of an acute toxicity test on the perfluorinated compound Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M, indicating a 48-hour LC50 of 1.5 mg/L and a NOEL of 1.0 mg/L for the aquatic invertebrate Daphnia magna. 1923 AR226-0397 B5Q7ooRgwa4DJNO2p78j6brDk 32
The document reports the results of an acute toxicity test conducted by 3M Company on the perfluorinated compound Perfluorooctanesulfonylamido(ethyl)acetate (FC-109-X), finding a 96-hour LC50 value of 57 mg/L for fathead minnows (Pimephales promelas) and a no observed effect level of less than 1923 AR226-0396 aJKanqZvLzEnk59YLVREQ03rb 22
The document reports on an acute toxicity study of Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M Company, finding a 48-hour LC50 of 1.5 mg/L and a NOEL of 1.0 mg/L for the aquatic invertebrate Daphnia magna. 1923 AR226-0397 x1G0onkBQMg0jROy03qwnyz76 32
DuPont presented its comprehensive risk management strategy for PFOA to the EPA on January 31, 2005, emphasizing source reduction, voluntary commitments, and the need for open dialogue amid challenges related to safety perceptions and regulatory complexities. 1914 AR226-1914 vV41dpr5Gd6pDzDONwMGKbmjb 43
This document appears to be a report discussing health concerns related to the use of a new formulation of Wilson Leather Protector, which has been associated with acute chemical pneumonia and hypersensitivity symptoms in individuals exposed to its fumes. 1913 AR226-3712 em2ZgLKVLqk34xnp32NZKGEqp 2
The document outlines an ongoing occupational health study on PFOA involving 1,025 current workers at the DuPont Washington Works site, focusing on the relationship between serum PFOA levels and health outcomes through cross-sectional surveys and retrospective cohort mortality analyses. 1910 AR226-1910 O1Qw3KEzzgVqGDj3qbkv0VeQK 13
The document summarizes the results of acute toxicity studies conducted by Hazleton Laboratories on T-l*101, a fluorochemical surfactant produced by 3M, indicating that it is slightly toxic when administered orally to rats and practically non-toxic via dermal exposure in rabbits. 1908 AR226-0979 N2ymR2VdZ9qGDdqkoXGg8Nvjb 3
This document reports on a biodegradation test of Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M, indicating that while some biodegradation occurred, the results are inconclusive due to the mixture's composition and lack of detailed methodology. 1904 AR226-0404 LKeYLGyQb9XLZjq7J033Q6z53 14
The document reports on a biodegradation study of Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M, indicating a 90% mean DOC removal after 28 days, but concludes that no reliable conclusions can be drawn due to inaccuracies in the total organic carbon measurement. 1904 AR226-0405 p0Jgay0bgY2pqLLBJYrLgNJ6 15
The document reports on an acute toxicity test of a mixture identified as FC-129 (R1904) on fathead minnows, revealing an observed effect concentration of 54 mg/L. 1904 AR226-0406 kZEazBxw2xwObrMeJXQ1JVyJ 18
The document reports on an acute toxicity test of a mixture containing perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted on the aquatic plant Selenastrum capricornutum, revealing various EC50 values for cell count and average specific growth rate at different exposure times. 1904 AR226-0407 ev7vQXaOkanzw6V6aNgXOpvRq 11
The document reports that the 3-hour EC50 for activated sludge respiration inhibition due to the perfluorinated compound Perfluorooctanesulfonylamido(ethyl)acetate (FC-129) was determined to be greater than 1000 mg/L, based on a mixture tested by 3M Company. 1904 AR226-0408 QXXOvOoQKk8wjvLVDE4kBkORo 8
The document reports the results of a Microtox toxicity test on a mixture containing Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA), produced by 3M, indicating a 30-minute EC50 value of 274 mg/L for the test organism Vibrio fischeri. 1904 AR226-0409 GmjEbV0gmG4dGqJ3No61EErwv 13
The document reports on a biodegradation test of Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M, indicating that while some biodegradation occurred in aerobic conditions, the results are inconclusive due to the test sample being a mixture and lacking detailed methodology. 1904 AR226-0404 3w8gvRj5rmqpXbJXkMeqvqdx 14
The document reports on a biodegradation study of Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted by 3M, indicating a 90% mean DOC removal after 28 days, but concludes that no reliable conclusions can be drawn due to inaccuracies in the total organic carbon measurement and lack of characterization of the test substance. 1904 AR226-0405 Qkr28b8zYYJow4v4XL3xZmNbo 15
The document reports on an acute toxicity test of a mixture referred to as FC-129 (R1904) on fathead minnows, indicating that the observed effect concentration was 54 mg/L. 1904 AR226-0406 bkNvkg4G984Y4gbLoweaGa83 18
The document reports on an acute toxicity test of a mixture containing perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) conducted on the aquatic plant Selenastrum capricornutum, revealing various EC50 values for cell count and average specific growth rate at different concentrations. 1904 AR226-0407 Y6y2NMyKQM174w7dnogXEMbV 11
The document reports that the 3-hour EC50 for activated sludge respiration inhibition of the perfluorinated compound Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA) in a mixture from 3M was determined to be greater than 1000 mg/L, indicating no inhibition was observed. 1904 AR226-0408 k6Kk6Ry9mNzoBpgXy5OdOkDkB 8
The document reports the results of a Microtox toxicity test on a mixture containing Perfluorooctanesulfonylamido(ethyl)acetate (PFOSAA), produced by 3M, indicating a 30-minute EC50 value of 274 mg/L for the test organism Vibrio fischeri. 1904 AR226-0409 bB4bEBmp3ovE90yXL126QQdr1 13
This is a figure from a monitoring program related to the Oakdale Disposal Site in Minnesota, depicting various well types and their locations in relation to the site. 1904 AR226-3638 M4pjKBDw6VqB1K5zXqrEwxDyV 1
DuPont submitted corrected confidential business information (CBI) regarding polymeric products related to the Telomer Research Program, including CAS numbers and 2002 sales volumes, to the EPA as part of their commitment to provide data on perfluorinated compounds. 1903 AR226-1321 MGJX92bD4wYYpGjYEQ5qYBRZx 2
This laboratory report from 3M Environmental Laboratory details a PFOS dietary LC50 study with mallard ducks, revealing that PFOS levels in the sera and livers of the ducks increased with dosage but declined significantly between days 8 and 22 post-exposure. 1902 AR226-1030 ev0j9NjzOqygjDN1G1D3Rn17q 14
The document is a laboratory report from 3M Environmental Laboratory detailing a PFOS dietary LC50 study with mallard ducks, which found that PFOS levels in the sera and livers of the ducks increased with dose but declined significantly from day 8 to day 22 post-exposure. 1902 AR226-1030 nkXOj1rX3xeJvRvoYROjvD7v1 14
This laboratory report from 3M Environmental Laboratory details a PFOS dietary LC50 study with mallards, revealing that PFOS levels in the sera and livers of the ducks increased with dosage but declined significantly between days 8 and 22 post-exposure. 1902 AR226-1736 Z4LD4XgbZzRzyDbzZ3Ovbpjg7 14
This laboratory report from 3M Environmental Technology & Safety Services details a PFOS dietary LC50 study conducted on mallard ducks, revealing that PFOS levels in the sera and livers increased with dosage but declined significantly between days 8 and 22 post-exposure. 1902 AR226-1781 rex7w6mZm6oozdxgeQ9a2jQq7 14
The document is a laboratory report from 3M Environmental Technology & Safety Services detailing a PFOS dietary LC50 study with mallard ducks, which found that PFOS levels in the sera and livers of the ducks increased with dosage but declined significantly between days 8 and 22 post-exposure. 1902 AR226-1829 5kJqe1xYrOv6VbqNNnYbXyOvN 14
The document is an analytical report from 3M Environmental Laboratory detailing a PFOS dietary LC50 study conducted on mallards, which includes serum and liver data with specific concentrations of PFOS measured in various samples. 1902 AR226-1853 o3Bkd4Q8QyrVB38E0N600p2D 14
The TNO report details a study commissioned by 3M that investigates the effects of perfluorinated alkyl sulfonates (PFAS) on cholesterol and bile acid metabolism in ApoE3Leiden transgenic mice and rat hepatocytes. 1901 AR226-3763 50DBzMoQnmkg2OeY33yndkKwN 35
The TNO report details a study commissioned by 3M that investigates the effects of perfluorinated alkyl sulfonates, specifically PFBS and PFHS, on cholesterol and bile acid metabolism in transgenic ApoE3Leiden mice and rat hepatocytes, highlighting significant metabolic alterations. 1901 AR226-3758 oez5Z7LZQ1bw82YyLB3Rxv22r 207
DuPont submitted information to the EPA's Office of Pollution Prevention and Toxics regarding perfluorinated chemicals, including a precautionary TSCA 8(e) submission despite believing it did not trigger reporting obligations. 1900 AR226-1964 JNz64BdrwQYB9qG000KB7prKX 43
The document reports that a study conducted by E. I. du Pont de Nemours and Company determined the LD50 of an unspecified substance, likely a perfluorinated compound, to be 1900 mg/kg in male rats, indicating it is slightly toxic when administered as a single oral dose. 1900 AR226-2921 ba7yL9mzyV3kv12OO7Dn45xRD 4
E.I. du Pont de Nemours and Company submitted supplemental information regarding a retrospective exposure analysis of perfluorooctanoic acid (PFOA) intake over the past 53 years for residents in parts of Ohio and West Virginia, asserting that it does not trigger reporting obligations under TSCA 8(e) as it does not indicate substantial risk to health or the environment. 1900 AR226-3743 V35RNGrbLvXB9aqGMkzzV9e9w 1
E.I. du Pont de Nemours and Company submitted supplemental information to the EPA regarding a retrospective exposure analysis of perfluorooctanoic acid (PFOA) intake over the past 53 years in Ohio and West Virginia, asserting that it does not trigger reporting obligations under TSCA 8(e) as it does not indicate substantial risk to health or the environment. 1900 AR226-3743 ymJeZkoX0r0Zd9g71JmrkbYRd 1
E.I. du Pont de Nemours and Company submitted supplemental information regarding a retrospective exposure analysis of perfluorooctanoic acid (PFOA) intake over the past 53 years in Ohio and West Virginia, asserting that it does not trigger reporting obligations under TSCA 8(e) as it does not indicate substantial risk to health or the environment. 1900 AR226-3743 M5znXBMbk65vVYKM0MnD1YQk 1