|
The document outlines ongoing research protocols by 3M and Johns Hopkins University to identify and analyze levels of various fluorochemicals, including PFOS and PFOA, in the sera of children in the United States, with final reports due in 2001 and 2004.
|
2001 |
AR226-0019
|
7R1892VG9X55Gr3JrRJvM1m46 |
4 |
|
This document outlines a study by 3M to determine the concentration ratios of perfluorooctanesulfonate (PFOS) in human liver, bile, and serum, with the aim of understanding tissue concentrations and their significance, following ethical guidelines for tissue procurement.
|
2001 |
AR226-0021
|
yGXqnpjkaQ6ZwVmM392mDGB3 |
3 |
|
The document reports on a study conducted by 3M Company to evaluate the acute oral toxicity of a material identified as T-2001CoC in male and female albino rats, finding an LD50 between 0.5 ml/kg and 2.5 ml/kg, with significant effects observed at higher dosage levels.
|
2001 |
AR226-0217
|
emRqj5b4MkoavYoOYbX7geON4 |
2 |
|
The document reports on a primary eye irritation study conducted by 3M Company on a test material (T-2001CoC) involving albino rabbits, concluding that the material is not a primary ocular irritant but requires cautionary labeling.
|
2001 |
AR226-0218
|
XzdmoX43R5zR7zOgoqNo3QOVR |
3 |
|
The document details a primary skin irritation study conducted by 3M Company on a material (likely related to PFOA or PFOS) to assess its irritative effects on the skin of albino rabbits, following specific testing methods.
|
2001 |
AR226-0219
|
zQgQ4M1Dm4J0EON4VLGj8rMr7 |
3 |
|
The document announces that following negotiations, 3M will voluntarily phase out perfluorooctanyl sulfonate (PFOS) chemistry used in various products, with the EPA indicating it will monitor the phase-out and assess potential regulatory actions if necessary.
|
2000 |
AR226-0000
|
ykz222jZ3dvYZDMwzRDD9wYMr |
1 |
|
This document is a correspondence from Larry R. Zobel of 3M to Dr. Oscar Hernandez at the US EPA, providing previously omitted documents related to studies on PFOS and PFOA, including a fertility and developmental toxicity study in rats.
|
2000 |
AR226-0001
|
mpOaeGv28OXkV5BY9NGa2RO5b |
1 |
|
This correspondence from 3M's Medical Director, Larry R. Zobel, clarifies findings from a two-generation reproduction study on potassium perfluorooctanesulfonate (PFOS), stating that there were no significant effects on pup survival or growth at the 0.4 mg/kg/day dose, contrary to earlier reports.
|
2000 |
AR226-0002
|
oe5g96njYYw5307mKrVBp3ZnX |
6 |
|
3M is voluntarily providing the EPA with additional information on perfluorooctanesulfonate (PFOS), including studies on pharmacokinetics, teratology, and epidemiology, as part of ongoing discussions regarding fluorochemistry.
|
2000 |
AR226-0003
|
nmZ079Gg25xEaoo7R305xEEO1 |
10 |
|
This document details a series of studies conducted by 3M on the dermal absorption and pharmacokinetics of perfluorooctanesulfonate (PFOS) in New Zealand white rabbits to assess the absorption capacity of low-molecular-weight manufacturing residuals.
|
2000 |
AR226-0009
|
gbnqByLxk1bJ3E4n8gZMZ56BL |
4 |
|
The document summarizes an oral developmental toxicity study of potassium perfluorooctanesulfonate (PFOS) in rats, conducted by Riker Laboratories, which found maternal toxicity at the highest dose but no significant fetal toxicity, although a developmental eye abnormality was noted across all dose groups, leading to the conclusion that PFOS was teratogenic.
|
2000 |
AR226-0013
|
v19m6DyZ1YLy06agOOQLo0N4q |
3 |
|
This final report from 3M Environmental Laboratory concludes that there was no detectable dermal absorption of FC-95 (the potassium salt of perfluorooctanesulfonic acid, or PFOS) in rabbits at low dose levels, indicating that these doses may be insufficient to assess dermal absorption.
|
2000 |
AR226-0011
|
QXqEZqrr9N5QL9DLEdn7b73b6 |
95 |
|
The document is a final report from 3M Environmental Laboratory detailing an analytical study on the pharmacokinetics of the fluorinated compound FC-95 (T-6049) in rabbits, which confirmed the presence of perfluorooctanesulfonate in liver and serum after intravenous dosing.
|
2000 |
AR226-0012
|
jB9rw4oRY4J64D9pO9KK8Qddk |
82 |
|
The document outlines various analytical methods developed by 3M Environmental Laboratory for the extraction and analysis of Potassium Perfluorooctanesulfonate (PFOS) and other fluorochemicals from serum, liver, and urine using HPLC-Electrospray/Mass Spectrometry, detailing method numbers and adoption dates.
|
2000 |
AR226-0024
|
a4BNvgkVn1VwpZ9EQoVG222BR |
15 |
|
This document is a correspondence from 3M confirming the submission of a non-confidential version of a toxicological study on perfluorooctane sulfonates to the EPA, following a request from EPA's Terry O'Brien.
|
2000 |
AR226-0037
|
Rjda4dkJ0EnNOXd4x2amgYXvz |
1 |
|
This is a letter from the EPA's Office of Prevention, Pesticides and Toxic Substances, dated May 25, 2000, regarding information on perfluorooctane sulfonates, including a reference to additional studies and data submitted by 3M.
|
2000 |
AR226-0040
|
Lp1pYjZyn4enJgjnx41ggoX9z |
5 |
|
3M is requesting a one-week extension to respond to the EPA's information request regarding perfluorooctane sulfonic acid (PFOS) due to operational disruptions and seeks to discuss interpretation questions related to previous communications with the EPA.
|
2000 |
AR226-0041
|
KRJvJEY2mV738X4294npky0M0 |
1 |
|
The document outlines various reports and studies conducted by 3M regarding the health effects of Perfluorooctanesulfonate (PFOS) on male employees at their fluorochemical production facilities, including epidemiological investigations and assessments of serum fluorochemical levels.
|
2000 |
AR226-0030
|
jwend2rXG0aYvx7yVkDee775 |
190 |
|
3M submitted a "Use and Exposure Information Profile" to the EPA detailing the use and exposure related to perfluorooctane sulfonic acid (PFOS) and its salt forms, emphasizing that the majority of their fluorochemical production involves higher molecular weight derivatives and that less than 200,000 lbs/year of PFOS and its salts are commercialized as finished products.
|
2000 |
AR226-0042
|
10vK5QrL2dLnN3z9OV2v9G0Ya |
2 |
|
The document provides a voluntary use and exposure information profile for perfluorooctane sulfonate (PFOS) and its various salt forms produced by 3M Company, detailing their manufacturing process, site locations, and estimated distribution quantities.
|
2000 |
AR226-0043
|
penGV3Rw4jbrOL3zJwwRvDrQj |
30 |
|
3M is providing the EPA with additional voluntary information on perfluorooctane sulfonates, including studies on their environmental properties and health effects, as part of ongoing discussions regarding fluorochemistry.
|
2000 |
AR226-0044
|
LJDJQxZJYrJx2wQxeE5OXyoZz |
31 |
|
The document contains various laboratory reports and summaries related to the physical and chemical properties of perfluorooctanesulfonate (PFOS), including studies on its melting point, vapor pressure, partition coefficient, and solubility, conducted by Wildlife International, Ltd. and 3M Environmental Lab.
|
2000 |
AR226-0055
|
LJNLOOMVd8dRpXzxzkraR0NvX |
39 |
|
The document outlines the design and structure of a Multi-City study submitted to 3M Environmental Laboratory, aimed at obtaining preliminary data on the dispersion of fluorochemical compounds, including PFOA, in the environment and their potential sources of human exposure.
|
2000 |
AR226-0063
|
DGQOz6M8jGX9EonnOQ7NBqd6o |
7 |
|
The document contains attachments to a letter discussing various studies and information related to the acute toxicity and genotoxicity of perfluorooctane sulfonate (PFOS) and its derivatives, conducted by Biosearch, Inc. and Hazelton Washington for 3M.
|
2000 |
AR226-0291
|
3N8rQ6jL91aJR9axGKG058EqE |
4 |
|
The document contains various studies and tests conducted by Riker Laboratories and other institutions on the acute toxicity, immunotoxicity, genotoxicity, and repeated-dose toxicity of N-ethylperfluorooctane sulfonamidoethyl acrylate (T-3493), a perfluorinated compound produced by 3M.
|
2000 |
AR226-0304
|
RJ8QJv6wBq94ZyLqN31Y200mX |
10 |
|
The document details various toxicity studies conducted by Riker Laboratories, Inc. on the perfluorinated compound N-ethyl perfluorooctane sulfonamido ethyl methacrylate (T-3494), including acute oral toxicity, skin irritation, ocular irritation, immunotoxicity, and genotoxicity assessments.
|
2000 |
AR226-0312
|
99nqqz0q4va3QK1LJR1MQNMJL |
10 |
|
This document contains studies and evaluations of the mutagenic activity of N-methylperfluorooctane sulfonamidoethyl acrylate (T-5869), conducted by NOTOX for 3M, including results from the Ames Salmonella test and chromosome aberration tests, all compliant with GLP standards.
|
2000 |
AR226-0317
|
x5OMKxbBN1kga1MpeOG2aEKyb |
24 |
|
The document contains attachments related to studies on the acute toxicity and pharmacokinetics of perfluorooctane sulfonate (PFOS) and its derivatives, specifically detailing various toxicity tests conducted by 3M and other laboratories.
|
2000 |
AR226-0320
|
rB0vdVgqn01GvMd0GypLRD7e0 |
32 |
|
The document details a dietary acute study on the effects of perfluorooctanesulfonate (PFOS) conducted on mallard ducks, using a sample from 3M with a purity of 90.49%, to assess toxicity and establish LC50 values under controlled conditions.
|
2000 |
AR226-0102
|
LJB22x8Zw5bdR0Xwzz5Mkj2eQ |
8 |
|
This document contains various studies and reports related to the genotoxicity and mutagenicity of perfluorooctane sulfonate (PFOS), including evaluations conducted by different laboratories and institutions, primarily focusing on Ames tests and chromosomal aberration assays.
|
2000 |
AR226-0128
|
J3LKnQbyByJRJGer4rVVgMzQX |
12 |
|
The document evaluates mutagenicity studies on perfluorooctanesulfonate (PFOS), a degradation product of perfluorooctanesulfonylfluoride produced by 3M, to assess its potential mutagenic/genotoxic risks based on various toxicological studies conducted.
|
2000 |
AR226-0135
|
emXLYakkxVK3md08mq6JZr1ay |
12 |
|
The document contains attachments related to various toxicity studies of Perfluorooctane Sulfonate (PFOS) conducted by the International Research and Development Corporation and Covance Laboratories, detailing findings from subacute and chronic studies in monkeys and rats.
|
2000 |
AR226-0137
|
baEVvZ7rxgONJBNYLao4vEy43 |
41 |
|
The document details the findings from a microscopic review of liver sections from rats in a chronic PFOS study, indicating that centrolobular hepatocyte hypertrophy is present in certain male groups, with some changes deemed adaptive and others potentially adverse, leading to a determination of NOAEL and NOEL for liver histologic changes.
|
2000 |
AR226-0141
|
K6e5Vp4Mdo5KYYekaxRwYayxo |
11 |
|
3M submitted additional information to the EPA regarding perfluorooctane sulfonates and related compounds, including various CAS numbers, as part of ongoing discussions about fluorochemistry, while noting that some information is confidential business information.
|
2000 |
AR226-0333
|
BvMOL4jXQ1v8BOzxmrG5O1Mrm |
20 |
|
The document announces that 3M will voluntarily phase out perfluorooctanyl sulfonate (PFOS) chemistry used in various products following negotiations with the EPA, with the agency committing to further evaluate potential risks to individuals and the environment.
|
2000 |
AR226-0000
|
jyNJq9dDR6pvKqbN4Zy9xOdrR |
1 |
|
This document is a correspondence from Larry R. Zobel of 3M to Dr. Oscar Hernandez at the US EPA, providing additional documents related to studies on PFOS and PFOA that were inadvertently omitted from a previous package.
|
2000 |
AR226-0001
|
a4j4DeMN79KxBExEeL0n8QYNR |
1 |
|
The document includes an exploratory 28-day oral toxicity study on PFOS and other chemicals, submitted by 3M under a claim of confidentiality, detailing the effects of these substances in rats.
|
2000 |
AR226-0153
|
Raq84pYqY9vovD7v35930BpEV |
1 |
|
The document contains various studies and reports related to the pharmacokinetics and skin absorption of perfluorooctane sulfonate (PFOS) conducted by 3M, including multiple animal studies and analytical data submitted to the EPA.
|
2000 |
AR226-0154
|
20rJGqmaQR7J7n6qkje8B0D6 |
6 |
|
This document is a final report on an analytical study conducted by 3M, which investigates the pharmacokinetics of the perfluorinated compound FC-99 (T-6053) in rabbits, finding that fluorine was detected in liver tissue after a single intravenous dose of 20 µg/kg but not at lower doses, indicating that the perfluorooctanesulfonate
|
2000 |
AR226-0157
|
rx8RRqQm7JVDjV78zevE00Z9E |
88 |
|
This document from 3M provides serum measurements of perfluorooctanesulfonate (PFOS) from two pharmacokinetic studies in rats, detailing the analytical results and offering assistance to the EPA in understanding the toxicological data.
|
2000 |
AR226-0160
|
zQXzQLzraLDVmbOo1mGV5Gp67 |
22 |
|
The document is a final report from 3M Environmental Laboratory detailing a single-dose dermal absorption/toxicity study of the perfluorinated compound FC-99 (T-6053) in rabbits, which found no significant differences in total organic fluorine levels between treated and control groups after 28 days.
|
2000 |
AR226-0158
|
XzxgyX81q28oNEg66a21qeXyw |
135 |
|
The document outlines research proposals and studies conducted by Kendall B. Wallace at the University of Minnesota Duluth, focusing on the biochemical and molecular mechanisms of perfluoroalkyl sulfonamides, particularly perfluorooctane sulfonate (PFOS), with the aim of establishing methods to monitor health risks associated with exposure to perfluoroalkyl acids and their derivatives.
|
2000 |
AR226-0165
|
gLDeLYXJzEM8JmbDLV2DmaxQ |
12 |
|
This report details the effects of a single acute dose of PFOS on catalase and acylCoA oxidase gene expression and enzyme activity in liver tissue from rats and guinea pigs, indicating the methodology and analysis used to assess these impacts.
|
2000 |
AR226-0171
|
XLg3bB1ORp2EgNB6pQr03oLG |
6 |
|
The document discusses various studies and analyses related to perfluoroctane sulfonate (PFOS) in human sera, including blood testing results from Decatur workers and children, highlighting the relationship between organic fluorine concentrations in blood and exposure levels.
|
2000 |
AR226-0174
|
rxaKdJRQM1611BdzqVw98QvO7 |
7 |
|
The document is a final report of a pilot teratology study in rats (Project No. 154-158) conducted by Hazleton Laboratories for 3M, focusing on the effects of perfluoroctane sulfonate (PFOS).
|
2000 |
AR226-0173
|
QgQw2OVa6V40dNvmXdEnR1yQ5 |
48 |
|
The document outlines ongoing studies related to Perfluorooctane Sulfonic Acid Potassium Salt (PFOS) being conducted by Covance Laboratories and 3M, including a 104-week dietary chronic study in rats and a 26-week capsule toxicity study in cynomolgus monkeys, with interim data provided for both.
|
2000 |
AR226-0179
|
n9MBbQDvq1DOozBoZzQeEJZqX |
12 |
|
This document outlines a research project by 3M, led by Deanna J. Luebker, aimed at investigating the mechanism by which perfluorooctane sulfonic acid (PFOS) induces adverse effects on peri-/postnatal development in rats, specifically through the inhibition of HMG-CoA reductase and potential mitigation of toxicity via mevalonate co-administration.
|
2000 |
AR226-0183
|
om5JbrNwQe5G1L7QXjYzdaYy3 |
16 |
|
The document outlines ongoing environmental studies on perfluorooctanesulfonates (PFOS) being conducted by various laboratories, including 3M Environmental Laboratory and Wildlife International, with expected completion dates for various toxicity tests and degradation studies in 2000.
|
2000 |
AR226-0184
|
z2zBg6wapDkpDdEZ84GZnpjz |
12 |
|
The document outlines a planned one-generation reproduction study of perfluorooctane sulfonate (PFOS) in rats, focusing on pharmacokinetic analysis and involving various dose groups to assess the effects on pregnant rats and their pups.
|
2000 |
AR226-0192
|
5D95o5K9RVdVq0mGXeV1bZ4m4 |
5 |
|
This document outlines a draft study protocol for a one-generation reproduction study of PFOS in female Harlan CD rats, aiming to investigate whether co-administration of mevalonic acid or cholesterol can mitigate adverse maternal and fetal effects observed in a previous study, while also refining the no observed effect level (NOEL).
|
2000 |
AR226-0193
|
jXLRaDrO3Nk4aa2RMJ5NmwRk |
5 |
|
The document provides data from 1974 environmental studies conducted by 3M on the acute toxicity of perfluorooctanesulfonate (PFOS) ammonium salt (FC-93) to fathead minnows, including details on the test substance composition and experimental conditions.
|
2000 |
AR226-0194
|
9JwgoZq3GYzwpbRz0bvqG7Z83 |
11 |
|
The document lists various acute toxicity studies conducted by Biosearch Inc. and Riker Laboratories on perfluorooctane sulfonate (PFOS) and related compounds, detailing the test subjects, methods, and dates of the studies.
|
2000 |
AR226-0197
|
rxKqzo06GgbMBXLQEJL2JDD2E |
2 |
|
This document is an attachment to a letter discussing published studies on perfluorooctanesulfonates (PFOS) and perfluorooctanoic acid (PFOA), highlighting various environmental and toxicological research findings related to these perfluorinated compounds.
|
2000 |
AR226-0198
|
ZB9D6EY1vv9KOb4QbKk4kLYR0 |
2 |
|
3M is providing the EPA with additional information on perfluorooctylsulfonate (PFOS) salts, including their chemical designations and applications, as part of ongoing discussions regarding fluorochemistry.
|
2000 |
AR226-0200
|
per6mrMgkDzMRGK4JxVogOkZ6 |
3 |
|
This is a letter from Latham & Watkins to Dr. Charles Auer at the EPA, enclosing an analytical report from 3M's environmental monitoring program regarding perfluorinated materials, specifically detailing biosphere sampling and analysis results dated May 10, 2000.
|
2000 |
AR226-0201
|
QkVxR759XNK3GvxxprZxRvKaR |
2 |
|
3M is providing supplemental information to the EPA regarding perfluorooctane sulfonates (PFOS), including executive summaries and a summary of a 26-week toxicity study in cynomolgus monkeys, to complete their previous submission.
|
2000 |
AR226-0203
|
93kqxkYX1G5ZZqL0rx2NZGa4L |
8 |
|
3M is providing the EPA with additional information on perfluorooctane sulfonates and related compounds, including various CAS numbers, as part of ongoing discussions regarding fluorochemistry, while noting that some information is confidential business information.
|
2000 |
AR226-0204
|
xzwGQ6qyve3yw3zqjNZ51R5yE |
51 |
|
The document contains a summary of acute toxicity studies related to perfluorooctane sulfonylamido (ethyl)acetate (PFOSAA) conducted by Biosearch, Inc. and Riker Laboratories for 3M, detailing various toxicity tests on rats and rabbits from 1978 to 1982.
|
2000 |
AR226-0216
|
aK3bX7308X2J7Qrowzzd1dna |
5 |
|
The document contains various studies and reports from Hazelton Laboratories America, Inc. regarding the acute toxicity, genotoxicity, and pharmacokinetics of perfluorodecanesulfonate (PFDS) and other perfluorooctane sulfonate-related compounds, primarily conducted for 3M.
|
2000 |
AR226-0228
|
zdD75BOKoDzK77dpm6QzYQMQ7 |
17 |
|
This document is a final report of a pharmacokinetic study conducted by 3M on the test substance FC-129 (T-6054), which found that perfluorooctanesulfonate was a significant component of total organic fluorine detected in rabbit liver samples 48 hours after intravenous dosing.
|
2000 |
AR226-0226
|
0gNjxmw0xm92awVxbLgxNKGLn |
96 |
|
This final report from 3M Environmental Laboratory details a dermal absorption and toxicity study of the perfluorinated compounds FC-129 (T-6051 and T-6054) in rabbits, finding that approximately 0.2% of the highest administered dose of FC-129 (12.8 mg/kg) was absorbed into the liver after 28 days.
|
2000 |
AR226-0225
|
GEQp32jj5LXb5RemELd26wyq |
151 |
|
The document contains attachments to a letter discussing various acute toxicity and genotoxicity studies related to N-ethyl perfluorooctanesulfonamide (N-EtFOSA) and other perfluorooctane sulfonate-related compounds conducted by Riker Laboratories and Coming Hazelton, primarily focusing on tests performed on albino rats.
|
2000 |
AR226-0236
|
VGJv4j0pByo37ob8YXKer9n7g |
15 |
|
The document is a final report from 3M Environmental Laboratory detailing a pharmacokinetic study of the perfluorinated compound FC-120 (T-6052) in rabbits, which found detectable organic fluorine levels in liver samples only at higher doses.
|
2000 |
AR226-0235
|
ZJRBb79xa28z2opQK1LNKrEKd |
143 |
|
The final report from 3M's Environmental Laboratory indicates that a single-dose dermal absorption study of the perfluorinated compound FC-120 (T-6052) in rabbits showed no significant organic fluorine absorption at the highest dose of 1000 mg/kg, rendering the pharmacokinetic assessment unsuccessful.
|
2000 |
AR226-0234
|
Vdrj8Vqbxby17jw06b54rxng |
183 |
|
The document contains various toxicity and genotoxicity study reports on N-methyl perfluorooctanesulfonamide (N-MeFOSA) conducted by Hazleton Laboratories for 3M, detailing acute oral toxicity, dermal irritation, eye irritation, and mutagenicity assays.
|
2000 |
AR226-0242
|
8RXa0E4QG0wqaRRqJGmr5OEe |
51 |
|
The document contains attachments related to studies and information on perfluorooctane sulfonate (PFOS) and its related compounds, including acute toxicity, genotoxicity, and repeated-dose toxicity studies conducted by Hazelton Laboratories and International Research and Development Corporation.
|
2000 |
AR226-0249
|
V3QzppbGeaeyb9zwe0RKeQbL8 |
20 |
|
The document reports on a developmental toxicity study of N-EtFOSE (N-Ethyl-Perfluoroocyanesulfonamido Ethanol) in pregnant rabbits, finding that while there were dose-related effects on body weight and food consumption at higher doses, the compound was not teratogenic as no malformations were observed in the fetuses.
|
1999 |
AR226-0274
|
4JxG3zZB5QvJX2mRyOX4qOgRe |
1 |
|
The document outlines a protocol for a study on N-EtFOSE (N-Ethyl perfluorooctanesulfonamido ethanol) conducted by 3M's Corporate Toxicology Department, aimed at developing methods for collecting urine and bile specimens from treated rats to support an ongoing ADME study in Cynomolgus monkeys.
|
1999 |
AR226-0288
|
zzNvL23Q3Q8MOm259gR66XGpB |
7 |
|
This report evaluates the statistical quality of 12 data sources on serum perfluorooctanesulfonate (PFOS) levels in non-occupational human populations, finding that only pooled serum from U.S. blood banks was defensible for analysis, with a geometric mean PFOS blood level of 28.2 ppb.
|
1999 |
AR226-0036
|
ybzGXzkOYXxQZYqVE8vedNmd |
10 |
|
The document reports the vapor pressure of perfluorooctanesulfonate (PFOS), produced by 3M Company, as 3.31 x 10^-4 Pa at 20°C, determined using the Spinning Rotor Gauge method under GLP conditions.
|
1999 |
AR226-0047
|
81je0jDyjOMwojaN7jrbRgpa |
2 |
|
The document reports on a study conducted by Wildlife International, Ltd. for 3M Company to determine the n-octanol/water partition coefficient of perfluorooctanesulfonate (PFOS), which was ultimately deemed infeasible due to the formation of an inseparable emulsion during testing.
|
1999 |
AR226-0050
|
ydmV3r2ydwNGn3KQz3jwKEpE |
3 |
|
The document reports on a study conducted by Wildlife International Ltd. to determine the vapor pressure of PFOS using the spinning rotor gauge method, sponsored by 3M Corporation, and completed on May 5, 1999, while noting some deviations from Good Laboratory Practice Standards.
|
1999 |
AR226-0048
|
aDxeN3gbZGebbM778pd2aZbGy |
26 |
|
The document details a method developed by 3M's Environmental Laboratory to determine the air/water partition coefficient of perfluorooctanesulfonate (PFOS), indicating that the test substance was a white powder with unspecified purity and the experiment was completed in 1999 without following GLP standards.
|
1999 |
AR226-0051
|
J3vx6589XqXK85V7dg7BBLkae |
10 |
|
The document reports on a water solubility test for Perfluorooctanesulfonate (PFOS) conducted by 3M, finding an overall mean solubility concentration of 519 mg/L in NANOpure water.
|
1999 |
AR226-0054
|
71MX9kO44B1ZJxZyovQVL25ve |
22 |
|
The document reports on a study conducted by Wildlife International Ltd. for 3M Corporation to determine the water solubility of PFOS using the shake flask method, completed on May 3, 1999, with an amended report issued on April 26, 2000, and notes compliance with Good Laboratory Practice standards.
|
1999 |
AR226-0052
|
3Xx0EEzN7EyoBO5VoMYG2jgD |
35 |
|
The document presents a fugacity modeling study of perfluorooctanesulfonate (PFOS), conducted by Don Mackay, which concludes that PFOS tends to remain in water when released, with slow degradation and significant persistence in the environment.
|
1999 |
AR226-0060
|
85oNVbVqLbaE21z9Ywqj3GomK |
4 |
|
The document discusses the derivation of a draft lifetime Drinking Water Health Advisory (DWHA) for PFOS, based on a reference dose calculated using standard EPA methodology and a conservative uncertainty factor.
|
1999 |
AR226-0071
|
pBkok6KDNpkLGnL2dQyoOXGQE |
6 |
|
The document outlines a review of field sampling procedures conducted by Battelle during a city survey in Columbus, Georgia, as part of the Multi-City Human Exposure Assessment Study, focusing on the appropriateness of sampling techniques for fluorochemicals, including PFOA and PFOS.
|
1999 |
AR226-0072
|
v1gmMdx7428ZBRgy4pEzMbQrZ |
22 |
|
This is a field report from Battelle regarding a multi-city study conducted in Cleveland, Tennessee, and Decatur, Alabama, under Project Number N100672-01, focusing on the collection of samples for trace-level analysis of specific FC residuals.
|
1999 |
AR226-0073
|
LgxkewJ7YKGBOoqy0Oj6D2ObQ |
16 |
|
This is a final field report from Battelle (Project Number N100672-01) detailing the multi-city study conducted in Columbus, Georgia, and Port St. Lucie, Florida, focusing on the collection of samples for trace-level analysis of FOSE-based fluorochemical residuals.
|
1999 |
AR226-0074
|
2G7YDyB9qO4Xd8oJdDdX24L7 |
16 |
|
The document is a final field report detailing the multi-city study conducted by Battelle in Mobile, Alabama, and Pensacola, Florida, focusing on the sampling and analysis of perfluorinated compounds, including PFOA and PFOS, as part of Project Number N100672-01.
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1999 |
AR226-0075
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O3mmmnVMXma5RjQ06BxqwLOyv |
17 |
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The document outlines a study protocol by 3M to assess cell proliferation and peroxisome proliferation in rats administered N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), and N-Ethyl Perfluoroctanesulfonamide (PFOSA)
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1999 |
AR226-0290
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ba6dYJ9mabjp2rVqD2nMn1pe0 |
14 |
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The document discusses concerns regarding the conclusion of a dietary toxicity study on N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE) conducted by Covance Laboratories, specifically questioning the determination of the no observable adverse effect level (NOAEL) and the biological significance of weight gain reductions at various dosage levels in rats.
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1999 |
AR226-0301
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3N3zO7mLL6wMEREV8mKV5BaD0 |
1 |
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This document is an amendment to the Quality Assurance Project Plan for the Multi-City Study Sampling Task, prepared by Battelle, which outlines changes to sampling protocols, including the addition of labeling for 'Trip Blank' samples.
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1999 |
AR226-0077
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EdrZJm6RBzGKQDyvg7MMQMk4 |
23 |
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This document details an acute toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the fish species Pimephales promelas, using a sample from 3M with a purity of 90.49%, following OECD and OPPTS guidelines, and completed in 2000.
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1999 |
AR226-0082
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37LG6w3rrkXjem70vdJgobpxn |
4 |
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The document details a toxicity study of Perfluorooctanesulfonate (PFOS) conducted by 3M, which assessed its effects on the aquatic plant species Selenastrum capricornutum over a 96-hour exposure period, with a measured purity of 90.49%.
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1999 |
AR226-0084
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O3w4bNRw37BeaG8jmMpyxVorM |
6 |
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This document details an acute toxicity study of perfluorooctanesulfonate (PFOS) on the aquatic invertebrate Daphnia magna, conducted under OECD guidelines, with a purity of 90.49% and results indicating the EC50 values calculated for PFOS exposure.
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1999 |
AR226-0086
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ByJJOvMdM356evMxvpjaxvXmJ |
4 |
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The document details a study on the acute effects of perfluorooctanesulfonate (PFOS) on the shell growth of the Eastern oyster (Crassostrea virginica), using a sample from 3M with a purity of 90.49%, and outlines the methodology and statistical analysis used to determine the impact on shell growth over a 96-hour exposure period.
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1999 |
AR226-0088
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3wJvzz4rDyBve6N48MVkbDvJ |
4 |
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This document reports on an acute toxicity study of perfluorooctanesulfonate (PFOS) conducted on the freshwater mussel species Unio complanatus, detailing the test conditions, methods, and analytical results from a sample sourced from 3M.
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1999 |
AR226-0090
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bBkmJGd1gkOoj7GnLgq9de9y3 |
4 |
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The document details an OECD 209 activated sludge respiration inhibition test conducted on perfluorooctanesulfonate (PFOS) sourced from 3M, which was found to have a purity of 90.49% and involved assessing its impact on dissolved oxygen concentrations in activated sludge from a wastewater treatment facility.
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1999 |
AR226-0092
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3Qeg0y5aZLQ1KVkB2V873dgoy |
3 |
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This document is an amended final report from Wildlife International Ltd. on a 96-hour shell deposition test conducted with the Eastern Oyster (Crassostrea virginica) to assess the effects of PFOS, sponsored by 3M Corporation, and it states compliance with Good Laboratory Practice standards while noting some exceptions in the characterization of the test substance.
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1999 |
AR226-0089
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npOzjNgaXknbXoN929OJwLMp8 |
56 |
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This document is an amended final report of a 96-hour static acute toxicity test conducted by Wildlife International Ltd. on PFOS using the freshwater mussel (Unio complamatus), sponsored by 3M Corporation, and it outlines compliance with Good Laboratory Practice standards while noting exceptions in substance characterization and stability determination.
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1999 |
AR226-0091
|
JJmomLXgrrDn7nG6mO76deKwK |
59 |
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The document details a study on the acute toxicity of perfluorooctanesulfonate (PFOS) to the saltwater mysid species Mysidopsis bahia, conducted by Wildlife International, Ltd., which determined the substance's purity to be 90.49% and involved a 96-hour exposure period to assess lethal concentration (LC50) values.
|
1999 |
AR226-0094
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wgvXyayq5kLvwB0jbg9zpjM94 |
4 |
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This document reports on a chronic toxicity study of perfluorooctanesulfonate (PFOS) conducted on early life stages of fish (Pimephales promelas) using a flow-through method, with a purity of 90.49% and significant statistical analysis performed to assess the effects of PFOS exposure over a 47-day period.
|
1999 |
AR226-0096
|
wggxnKLxKKybgwLa3KDLjpv14 |
5 |
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This document details a chronic toxicity study of perfluorooctanesulfonate (PFOS) on freshwater invertebrates (Daphnia magna), conducted by Wildlife International, Ltd., which assessed survival, reproduction, and growth over a 21-day exposure period.
|
1999 |
AR226-0098
|
owG9V6zMowbewbkYBvdgKmdg |
6 |
|
The document details a chronic toxicity study of Perfluorooctanesulfonate (PFOS) conducted on the saltwater mysid species Mysidopsis bahia, using a sample from 3M with a purity of 90.49%, and outlines the methods and statistical analyses employed to evaluate the effects of PFOS over a 35-day exposure period.
|
1999 |
AR226-0100
|
MJOy7n80RRY6Bx7oEwXOmDwLV |
7 |
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The document is a final report on an early life-stage toxicity test of PFOS conducted with fathead minnows (Pimephales promelas) by Wildlife International Ltd. for 3M Corporation, completed on April 26, 2000, and compliant with Good Laboratory Practice standards.
|
1999 |
AR226-0097
|
3m65nOZdQZqw4292L1011pL3 |
88 |
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The document is a final report on a semi-static life-cycle toxicity test of PFOS conducted with the cladoceran Daphnia magna, sponsored by 3M Corporation and compliant with Good Laboratory Practice standards.
|
1999 |
AR226-0099
|
MMkZb1zMjEdxbZN6epvgvB50j |
93 |
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This document details a dietary acute study on the effects of perfluorooctanesulfonate (PFOS) on Northern bobwhite quail, conducted by Wildlife International Ltd., which involved testing the substance's concentration and stability in feed over a specified exposure period.
|
1999 |
AR226-0104
|
ypjrp1Gd56NkwjBdp4YkNOBLr |
9 |
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The document is a final report on a flow-through life-cycle toxicity test of PFOS conducted with the saltwater mysid (Mysidopsis bahia) by Wildlife International, Ltd. for 3M Corporation, indicating compliance with Good Laboratory Practice standards despite some exceptions in substance characterization.
|
1999 |
AR226-0101
|
kD2MNn8V78mkK9rx9BQLZj8XJ |
76 |