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This is a final report from EnviroSystems Division of Resource Analysts, Inc. (Study Number 90171-3) detailing the static acute toxicity of FM 3820 to the daphnid, Daphnia aqua, conducted for 3M Company over 88 hours in December 1990.
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AR226-0119
|
Ew57y3GY2xDYj5VdrnNnO38g |
17 |
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The document reports on the acute toxicity of the substance FH 3820 to the alga Seleoastcum capricomutua, revealing a 96-hour EC50 of 255 µg/L and a no observed effect concentration (NOEC) of 125 µg/L.
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AR226-0122
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VjGjY9a8mnGV0X6xJ4RgqrkYK |
25 |
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The document reports on a study conducted by 3M Company to assess the acute oral toxicity of a material identified as T-2297CoC in albino rats, finding that the LD50 is greater than 0.05 gm/kg but less than 1.5 gm/kg, with observable symptoms at the higher dosage.
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AR226-0126
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0jOgw56B2mx51gZr3gjQVnEM |
2 |
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The document is a final report prepared for 3M Corporate Toxicology detailing a study on unscheduled DNA synthesis in rat liver primary cell cultures using PFOS, conducted by Covance Laboratories and compliant with EPA Good Laboratory Practice regulations.
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AR226-0132
|
re2k6qjNQjwQQ74pnQMQVwezr |
36 |
|
The document is a final report from Covance Laboratories on a Salmonella-Escherichia coli mammalian-microsome reverse mutation assay conducted with PFOS, prepared for 3M Corporate Toxicology, indicating compliance with EPA Good Laboratory Practice regulations.
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AR226-0133
|
xjJK9N7gNLR78LzpX4jXYVKOg |
43 |
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The document is a final report on a primary dermal irritation/corrosion study of the test material T-5898, conducted on rabbits to assess skin irritation levels, in compliance with OECD guidelines.
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AR226-0325
|
6bgO8Xo5Q12GaO4Jmb5a3VKK1 |
11 |
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The document is a final report on an acute oral toxicity study of the test material T-5898, conducted on rats, to assess its toxicity under OECD guidelines.
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— |
AR226-0323
|
dQ22BkELQMqwZbZ2EzBq6go19 |
24 |
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The document is a draft final report for a 5-daily dose dermal absorption/toxicity study of the substance T-6684, sponsored by 3M, conducted on rabbits at Covance.
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AR226-0327
|
OJqR5mme65za5p33O2RzdEqZM |
53 |
|
This document appears to be a laboratory report cover page related to the analysis of PFOS and PFOSA, although the specific details and analytical content are not clearly legible due to OCR errors.
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AR226-0331
|
p6KyErZzmwdeV7z9gpVyEbRa |
7 |
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This document outlines a method for analyzing potassium perfluorooctanesulfonate (PFOS) and other fluorochemical surfactants in serum extracts using HPLC-electrospray/mass spectrometry, detailing the applicable compounds and matrices for testing.
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AR226-0025
|
zoY3XebLEbXpnXwEk7eNLnw66 |
9 |
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This study report from the University of Dundee investigates the levels of palmitoyl-CoA oxidation in frozen liver samples from 3M Environmental Laboratory, finding that PFOS at 20 ppm significantly increased PCoA oxidation compared to the control group.
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AR226-0143
|
7RD5JQOjazRYYrR35x2rK09x6 |
9 |
|
This is a laboratory report from 3M Toxicology Services detailing the methodology and clinical information for a 48-hour fecal urobilinogen analysis, with a focus on its diagnostic relevance for hemolysis and hepatic conditions.
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— |
AR226-0148
|
M4nw5x1v2r6VLMzbxexnYGgpy |
26 |
|
The document is an interim laboratory report detailing preliminary data from a 26-week toxicology study of PFOS conducted on Cynomolgus monkeys by Covance for 3M, indicating that PFOS levels generally increased across all dose groups throughout the study duration.
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— |
AR226-0151
|
ByyGj1264RjEjyaGmNZNJqM6k |
18 |
|
The document outlines a study protocol for evaluating the cytotoxicity of four test articles (T-6292, T-6293, T-6294, T-6295) provided by 3M, using isolated hepatocytes from rats to determine EC50 and EC10 values for subsequent in vitro metabolism studies.
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AR226-0161
|
L53oBnqnQazbvwNdEpG31pzz |
19 |
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The document discusses the metabolism of perfluorosulfonamide in rat versus human hepatocytes, highlighting the detection of metabolites from the compound FX-12 (IX) and noting improvements in analytical sensitivity in the testing methods used.
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AR226-0164
|
x53BZQ2X0zOEg5rBz0K54YJzJ |
1 |
|
The report by Kendall B. Wallace, Ph.D., summarizes research on the effects of six perfluorooctanonyl compounds (PFCs) supplied by 3M on mitochondrial bioenergetics in isolated rat liver mitochondria, finding that all compounds inhibited ATP synthesis through various mechanisms, including increased proton leak and membrane depolarization.
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AR226-0166
|
byby45B56JaNRb9w73GBxzYX3 |
10 |
|
This document reports on a study investigating the effects of perfluorinated arylalkylsulfonamides on the bioenergetics of rat liver mitochondria, supported by a grant from The 3M Company.
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AR226-0167
|
LpLemKkwmaQx19OE5vxb1JNE5 |
34 |
|
The document summarizes a study on the effects of various perfluorinated compounds (PFCs), specifically highlighting that the sulfonamide PF95M is a potent uncoupler of mitochondrial bioenergetics with an IC50 of approximately 1.5 µM, raising concerns about its potential bioaccumulation and toxicity.
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— |
AR226-0169
|
e70zEgYwY9DaXO8Y9bnDZOQ1E |
3 |
|
This document is a composite report from 3M Environmental Laboratory detailing the results of analyses of human sera samples for fluorochemical compounds, including PFOA and PFOS, collected between March and April 1998, with an emphasis on the data's immediate use for assessing potential human health concerns despite not always adhering to Good Laboratory Practices.
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— |
AR226-0178
|
9JGJj6EmQ7xe5brRmow2bkOm3 |
66 |
|
This document outlines a study protocol from 3M's Strategic Toxicology Laboratory aimed at isolating liver sub-cellular fractions and quantifying perfluorooctane sulfonate (PFOS) contents to investigate its effects on serum cholesterol levels and liver function.
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— |
AR226-0181
|
6R63dv939z9z3x2GV8kEzpGn6 |
6 |
|
The document outlines a study design for a 3M Microbial Metabolism Program aimed at optimizing conditions for enriching microbial populations capable of metabolizing fluorochemicals, including PFOA and PFOS, through various complex screening systems.
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— |
AR226-0185
|
qa05MJMBr0X73V3gMXqgyoE0G |
13 |
|
This document outlines a method for the determination of Perfluorooctane sulfonate (PFOS), Perfluorooctane Sulfonylamide (PFOSA), and Perfluorooctanoate (POAA) in water samples using liquid-solid extraction and high-performance liquid chromatography/tandem mass spectrometry (HPLC/MS/MS).
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— |
AR226-0190
|
reRXx3eQwYYgRw7gJRkDaqVJe |
17 |
|
The document details 3M's TSCA 8(e) submissions regarding various fluorochemicals, including perfluoroalkyl mixtures FC-95 and N-ethyl perfluoroalkyl sulfonamido ethanol, along with preliminary findings from teratology studies and responses to EPA inquiries about the presence of these compounds in employee blood.
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— |
AR226-0199
|
XRONLyYv5NRnwEQk95XakVRYd |
17 |
|
The document is a report of an acute oral toxicity study conducted by Hazleton Laboratories America, Inc. on a sample (T-3607) for Minnesota Mining and Manufacturing, involving the administration of a single dosage level of 5.0 mg/kg body weight to young adult male and female albino rats.
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— |
AR226-0207
|
Lop3Vw60nGDmv49LYxm7R7Je5 |
6 |
|
Unreadable document.
|
— |
AR226-0213
|
baQnng798dZJka8pZ9m7kpmDO |
7 |
|
The document outlines a pharmacokinetic study protocol by 3M to assess the absorption, clearance, and persistence of Perfluorooctane Sulfonamide (PFOSA) in rats, with a focus on potential metabolites including PFOS, using advanced analytical methods.
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— |
AR226-0214
|
o97VQeLQbQ2n4B4kjE6oNyvr3 |
10 |
|
The document is a final report from Hazleton Laboratories America, Inc. detailing a primary dermal irritation/corrosion study on a test substance identified as T-4102, conducted on rabbits according to OECD guidelines.
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— |
AR226-0231
|
M4dDaMekdoOxa15Lopw8G4zR7 |
9 |
|
The document is a final report from Hazleton Laboratories detailing an OECD eye irritation study conducted on rabbits using a test substance identified as T-4102, which is related to the toxicology assessment for Minnesota Mining & Manufacturing.
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— |
AR226-0230
|
x1aow5mV5gY2k0LVe2KEbM5jE |
17 |
|
This study investigates the mechanism of toxicity of the pesticide ethylperfluorooctane sulfonamide (NEPFOS) and its metabolite perfluorooctane sulfonamide (PFOS) on isolated rabbit renal cortical mitochondria, finding that PFOS acts as a protonophore that uncouples oxidative phosphorylation, while NEPFOS does not show this effect without being metabol
|
— |
AR226-0240
|
xJVy4n63Bzg9EDwq9ra4o2GE |
1 |
|
The document is a final report from Hazleton Laboratories America, Inc. detailing a study on the primary dermal irritation of a test material (T-3752) on rabbits, conducted according to OECD guidelines.
|
— |
AR226-0243
|
rpxr7wBLbzyk709mYQ8v6pp3q |
17 |
|
The document is a final report from Hazleton Laboratories America, Inc. detailing an OECD eye irritation study on a test substance identified as T-3752, which was conducted on young adult New Zealand White rabbits to assess ocular irritation effects.
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— |
AR226-0244
|
EqvD0dmZy0QE4VnNGJDqpmxE0 |
22 |
|
The document reports on the evaluation of the mutagenic activity of T-6906 using L5178Y mouse lymphoma cells, conducted by NOTOX B.V. in compliance with Good Laboratory Practice standards.
|
— |
AR226-0253
|
7RejY7k0QoExwDZQb45nRrZ86 |
31 |
|
The document is an amendment to a two-year oral toxicity/carcinogenicity study of fluorochemical FM-3924 in rats, clarifying that while high-dose female rats exhibited benign hepatic adenomas outside historical limits, the overall tumor incidence was low and FM-3924 was not considered carcinogenic under the study's conditions.
|
— |
AR226-0262
|
qaJYxvr8ajjLDBLm97jd223Eq |
4 |
|
The document details the results of GC/MS analyses of various perfluorinated compounds, including N-Ethyl and N-Methyl carboxamides, with specific percentages of each compound identified in the samples.
|
— |
AR226-0265
|
2qEnGzZnr441aQz48O31bqjda |
4 |
|
The document reviews a two-year oral toxicity and carcinogenicity study of the fluorochemical FM-3924 conducted on rats, highlighting significant findings of hepatocellular adenomas and carcinomas in high-dose female rats, along with notable reductions in body weight and liver weight increases in the high-dose group.
|
— |
AR226-0266
|
4v8ojRLE0n6zvBw03g28KK1d1 |
2 |