|
This document reports on pharmacokinetic studies of [14C]PFOS conducted on male Charles River CD rats, revealing that at least 95% of an oral dose was absorbed within 24 hours, with significant excretion observed in urine and feces, and no evidence of metabolic conversion of PFOS.
|
1979 |
AR226-0004
|
zDw6rbOoaOLkx1nY1Gg2wkx3 |
2 |
|
The document details the synthesis and characterization of carbon-14 labeled FC-95-14c, a sulfonic acid salt produced by 3M's Commercial Chemicals Division, which was found to be at least 99% radiochemically pure and suitable for metabolism studies.
|
1979 |
AR226-0005
|
JJ9Vky2EjrRvky57wMygmdm8a |
18 |
|
This document reports on a study conducted by Riker Laboratories on the pharmacokinetics of FC-95, a perfluorinated sulfonic acid, detailing the excretion rates and tissue concentrations of carbon-14 in male rats following intravenous administration.
|
1979 |
AR226-0006
|
LpaL0Nor5z4GBExykobj0XaNq |
19 |
|
The document reports on a study conducted by Riker Laboratories, Inc. on the absorption and elimination of FC-95 (a potassium salt of a perfluorinated sulfonic acid) in male rats, finding that at least 95% of the carbon-14 from a single oral dose is absorbed within 24 hours, with a plasma elimination half-life of 7.5 days.
|
1979 |
AR226-0007
|
EqgBeddqQKvpj0EpYrZ6zE0aj |
18 |
|
The document reports on a biodegradation study of Perfluorooctanesulfonate (PFOS DEA salt) conducted by 3M Company, indicating that while the non-fluorinated moiety (2,2'-iminobis[ethanol]) is likely to biodegrade in aerobic conditions, the potential for biodegradation of the fluorochemical moiety remains uncertain.
|
1979 |
AR226-0059
|
yrDvjX2O9rye245O5X1GKkBDd |
11 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-0068
|
orjkDjxXEjrzLj4ozqoD3orr |
8 |
|
The document reports on an acute oral toxicity study of T-2574COC, a perfluorinated compound, conducted on albino rats by Riker Laboratories, indicating an approximate oral LD50 between 5,000 and 1,000 mg/kg, with notable behavioral reactions and mortality observed at the higher dosage.
|
1979 |
AR226-0294
|
3GBkGq86KEaK1KxON7O8m1d6 |
11 |
|
The document reports on an activated sludge respiration inhibition test conducted by 3M Company on perfluorooctanesulfonate (PFOS DEA salt), indicating that the test material showed no inhibitory effect at a concentration of 1000 mg/L over a 7-minute exposure.
|
1979 |
AR226-0116
|
VJ53yDreK8MRMYxOVYGp6MJLj |
4 |
|
The document is a 90-day subacute toxicity study of the fluorochemical surfactant FC-95 produced by 3M Company, conducted on rhesus monkeys to evaluate its effects on health.
|
1979 |
AR226-0138
|
a10QeG4JM489d3YbzqyMENby |
24 |
|
The document details a 1979 environmental sampling study conducted by 3M on fish from the Tennessee River to assess the bioaccumulation of N-Ethylperfluorooctanesulfonamide (EtFOSA), with specific sampling methods and fish types noted but lacking standardized guidelines.
|
1979 |
AR226-0343
|
dQBKGQNOLBD315gv84Qk2yoz6 |
36 |
|
The document reports on a 28-day percutaneous absorption study of FC-98, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, which found no adverse effects but indicated dermal absorption potential that could not be conclusively determined due to limited sample analysis.
|
1979 |
AR226-0979
|
b5OGK6Lok9Ym2Q172wXz1ObYD |
16 |
|
The document reports on a 28-day percutaneous absorption study of FC-95, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, which found no mortalities but noted hyperactivity and body weight loss in some subjects, with preliminary serum analysis suggesting dermal absorption potential.
|
1979 |
AR226-0155
|
ExQ3ExXYGMEvVa1nRo6BmL8rx |
16 |
|
The document reports on a 28-day percutaneous absorption study of FC-99 conducted on albino rabbits at Riker Laboratories, Inc., which found no significant adverse effects but indicated potential dermal absorption of FC-99, although conclusive results could not be drawn due to limited serum analysis.
|
1979 |
AR226-0156
|
1ywjaEjZK6R7w2XOJ7J8K8dXm |
16 |
|
The report discusses the assessment of mitochondrial bioenergetics in rats treated with dietary FC10, highlighting that the use of pentobarbital for euthanasia confounded the ability to establish a dose-response correlation, and suggests alternative methods for analyzing metabolic dysfunction in exposed animals.
|
1979 |
AR226-0168
|
rrX7eyeJ9yNK2NzLVZrkK7e |
7 |
|
This analytical report from Centre Analytical Laboratories details the fluorochemical characterization of surface water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-0979
|
2qm8eRLLQkY2RNkGLkrdd1eo5 |
7 |
|
The document reports that SRI International conducted in vitro microbiological mutagenicity assays on 3M Company compounds T-2540 CoC and T-2541 CoC, finding that neither compound exhibited mutagenic or recombinogenic activity in any of the tested assays.
|
1979 |
AR226-0208
|
pmQNgke9QmD21oJ9n0m3Qmwqa |
23 |
|
A 28-day percutaneous absorption study of FC-129, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, Inc. revealed significant mortality and adverse behavioral reactions, indicating potential toxicity, though conclusive results on dermal absorption were limited due to the small sample size.
|
1979 |
AR226-0224
|
DMwqmQQ5vX0gYmKONoXgkVB6Q |
15 |
|
The document reports on a 28-day dermal absorption study of FC-128 conducted on albino rabbits at Riker Laboratories, Inc., indicating some dermal absorption but inconclusive results due to limited serum analysis.
|
1979 |
AR226-0223
|
10JMpYQLvb5OrEOvg7QO86Lja |
16 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-1030
|
3JXmDdmbQ62Yz5RzYbDQVp1Zx |
14 |
|
This analytical report from Centre Analytical Laboratories details the fluorochemical characterization of surface water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-1030
|
2q7GKzq798Zjxd1dOd3xNB3LN |
12 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of POTW effluent samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS
|
1979 |
AR226-1030
|
N2Od8gbGXQYxMYEnpDxX7JxGR |
9 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the characterization of sediment, leachate, and sludge samples from Decatur, Alabama, specifically analyzing for perfluorinated compounds including PFOS, PFOSA, and POAA using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-1030
|
x1z4DgqYqbwE3Gr8qvDde1qaE |
13 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-1030
|
NNKb5NYB4nkjrnazoR8rr7kxw |
14 |
|
This document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of POTW effluent samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS
|
1979 |
AR226-1030
|
wzLoD0R9mDaQY7EqbK40EaMV |
9 |
|
This document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of surface water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-1030
|
2Rgbj2qQwBm6yx4XBazmzV8eR |
12 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of sediment, leachate, and sludge samples from Decatur, Alabama, specifically analyzing for compounds including PFOS, PFOSA, and POAA as part of 3M Project W1979.
|
1979 |
AR226-1030
|
x1DvoY8Lm6D7Gze3RvwBeYw3g |
13 |
|
The document reports on a 204-day study of the photodegradation of N-methylperfluorooctane sulfonamidoethanol (FM-3925), conducted under natural sunlight, which concluded that no significant photodegradation occurred during the testing period.
|
1979 |
AR226-1030
|
qmmLKgrv4vbwa4BQEKknNK48M |
2 |
|
The document outlines a ninety-day subacute toxicity study on the compound FM-3422, conducted by the International Research and Development Corporation for 3M Company, focusing on its effects in rhesus monkeys.
|
1979 |
AR226-0256
|
2JE2MwjvXXdDzqwNzQJD8NZXN |
35 |
|
The document reports that SRI International conducted in vitro microbiological mutagenicity assays on 3M Company compounds T-2540 CoC and T-2541 CoC, finding that neither compound exhibited mutagenic or recombinogenic activity in any of the tested assays.
|
1979 |
AR226-0208
|
NrvVgkm5bNZR7rO4L0pqr7gy |
23 |
|
A 28-day percutaneous absorption study of FC-129, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, Inc. revealed significant mortality and adverse behavioral reactions, indicating potential toxicity, although definitive conclusions on dermal absorption could not be established due to limited serum analysis.
|
1979 |
AR226-0224
|
zgBLjaG9e9qkL1royd2Rq25n |
15 |
|
The document reports on a 28-day dermal absorption study of FC-128, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, which found evidence of dermal absorption but lacked sufficient data for definitive conclusions.
|
1979 |
AR226-0223
|
YbBKqQq6vbODQNGdGwJMRojK |
16 |
|
The document outlines a ninety-day subacute toxicity study of the compound FM-3422, produced by 3M Company, involving rhesus monkeys and detailing methods, observations, and results related to clinical and pathological assessments.
|
1979 |
AR226-0256
|
2qnRrYMKBk2Q3dz69r7K4dK06 |
35 |
|
This document reports on pharmacokinetic studies of [14C]PFOS conducted on male Charles River CD rats, revealing that at least 95% of an oral dose was absorbed within 24 hours, with significant excretion observed in urine and feces over 89 days, and no evidence of metabolic conversion of PFOS was found.
|
1979 |
AR226-0004
|
wq7kpXkeg3enM2NkZz4vMj8mE |
2 |
|
The document details the synthesis and characterization of carbon-14 labeled FC-95-14c, a sulfonic acid salt produced by 3M's Commercial Chemicals Division, which was found to be at least 99% radiochemically pure and suitable for metabolism studies.
|
1979 |
AR226-0005
|
vVk43qRVeG7eLraear28eqrgw |
18 |
|
This document reports on a study conducted by Riker Laboratories in 1979 examining the excretion and tissue distribution of carbon-14 labeled FC-95, a perfluorinated sulfonic acid, in male rats following intravenous administration, revealing significant urinary and fecal excretion rates and tissue concentrations.
|
1979 |
AR226-0006
|
6B2Y0ZJggmzojox9RKXqde26R |
19 |
|
The document reports on a study conducted by Riker Laboratories, Inc. on the absorption and elimination of FC-95 (a potassium salt of a perfluorinated sulfonic acid) in male rats, finding that at least 95% of a single oral dose is absorbed within 24 hours and has a plasma elimination half-life of 7.5 days.
|
1979 |
AR226-0007
|
QXKpJw96VN7kaqOMV4YME98D6 |
18 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the characterization of surface water samples collected in Decatur, Alabama, specifically analyzing for perfluorinated compounds including PFOS, PFOSA, and POAA, as requested by 3M Environmental Laboratory.
|
1979 |
AR226-0672
|
KJ7Zkn75vLxNpJGO2NQprvLRN |
7 |
|
This document reports on a biodegradation study of Perfluorooctanesulfonate (PFOS) DEA salt conducted by 3M Company, indicating that while the non-fluorinated moiety (2,2'-iminobis[ethanol]) is likely to biodegrade in aerobic conditions, the potential for biodegradation of the fluorochemical moiety remains uncertain.
|
1979 |
AR226-0059
|
1g33JqpYL9k32GbpBjrRz5vRd |
11 |
|
This document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of drinking water samples from Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS).
|
1979 |
AR226-0068
|
qd0Z064MBRvawe6kwMLeBYa6M |
8 |
|
The document reports on an activated sludge respiration inhibition test conducted by 3M Company on perfluorooctanesulfonate (PFOS DEA salt), indicating that the test material showed no inhibitory effect at a concentration of 1000 mg/L over a 7-minute exposure.
|
1979 |
AR226-0116
|
omjpgZgmz699OzzwRmJZ7K2j8 |
4 |
|
The document is a 90-day subacute toxicity study on the fluorochemical surfactant FC-95 produced by 3M Company, conducted on rhesus monkeys to assess its effects on health.
|
1979 |
AR226-0138
|
nNNmBRE04Zm8191aZ8q2GN8za |
24 |
|
The document details an acute toxicity test conducted on mummichogs (Fundulus heteroditus) using a mixture containing 1.34% perfluorooctanesulfonate (PFOS) to assess its effects, following a standard marine bioassay procedure.
|
1979 |
AR226-0724
|
ym77p0NQdKG2eDEqYwnQ32aK4 |
15 |
|
This document details an acute toxicity test conducted on the Eastern Oyster (Crassostrea virginica) using a test substance identified as PFOA, following standard practices for static acute toxicity tests, with results indicating specific toxicity levels.
|
1979 |
AR226-0725
|
KGpYpovJ2NDz7JGX2jVbZKk1o |
12 |
|
The document reports on a 28-day percutaneous absorption study of FC-95 conducted on albino rabbits at Riker Laboratories, which found no mortalities but noted hyperactivity and body weight loss in one male rabbit, with preliminary serum analysis indicating dermal absorption potential of FC-95.
|
1979 |
AR226-0155
|
qmMDV0komvQN5p12GQ1ma8LwK |
16 |
|
The document reports on a 28-day percutaneous absorption study of FC-99 conducted on albino rabbits at Riker Laboratories, Inc., indicating dermal absorption potential but lacking conclusive results due to limited serum analysis.
|
1979 |
AR226-0156
|
v6DKbo366zODeNjEVXQ3kE7eR |
16 |
|
The report discusses the assessment of mitochondrial bioenergetics in rats treated with dietary FC10, highlighting the confounding effects of pentobarbital on pyruvate oxidation, which hindered the establishment of a dose-response correlation, and suggests alternative methods for analyzing metabolic dysfunction in exposed animals.
|
1979 |
AR226-0168
|
aJND548jdb2qXravmX78V2z6Y |
7 |
|
The document reports on an acute toxicity test of a mixture containing 0.92% PFOS (perfluorooctanesulfonate) conducted on fathead minnows (Pimephales promelas) to assess the effects of the substance, with details on the test conditions and methodology.
|
1979 |
AR226-0796
|
vyp1GGY9n7OJRJGr933RoVDeq |
10 |
|
The document details an acute toxicity test conducted on fathead minnows (Pimephales promelas) using a mixture containing 0.92% PFOS, revealing the test conditions and methodology but noting that data may not accurately reflect the toxicity of the fluorochemical component due to incompletely characterized impurities.
|
1979 |
AR226-0797
|
29G3Gqde2k7XaaN80JNwE7 |
7 |
|
The document reports on an acute toxicity test of a mixture containing 0.92% PFOS, conducted on Daphnia magna, indicating the test conditions and parameters used, although it notes that the data may not accurately reflect the toxicity of the fluorochemical component due to incomplete characterization of impurities.
|
1979 |
AR226-0798
|
Jr8ekaVYDdZz38BkNjgk0Ea9e |
6 |
|
The document details a microbial inhibition test on a mixture containing 0.92% perfluorooctanesulfonate (PFOS) produced by 3M, indicating that the data may not accurately reflect the toxicity of the fluorochemical component due to incompletely characterized concentrations of impurities.
|
1979 |
AR226-0799
|
npLXv909Mm8YLwjopaMo12e2X |
7 |
|
The document reports on an activated sludge respiration inhibition test conducted on a mixture containing 0.92% PFOS, produced by 3M, which found no acute inhibitory effects on activated sludge respiration at a concentration of 1000 mg/L.
|
1979 |
AR226-0800
|
byDx7d69ReVrXRrm7dXopmzJ0 |
5 |
|
The document details an acute toxicity test conducted on the fish species Fundulus heteroclitus using a mixture containing 0.58% perfluorooctanesulfonate (PFOS) and other components, following a standard marine bioassay procedure to determine the LC50 values over a 96-hour exposure period.
|
1979 |
AR226-0873
|
zQmdaRnZw0jJYNyrzXK54w6Ym |
15 |
|
This document reports on a biodegradation test of a mixture containing perfluorooctanesulfonate (PFOS) conducted by 3M Company in 1979, noting high biochemical oxygen demand (BOD) values but lacking detailed methodology and sample characterization.
|
1979 |
AR226-0875
|
dQ6peOGOXO4KYe6xb591J3LJQ |
9 |
|
The document reports on an activated sludge respiration inhibition test for a mixture containing 1.0% PFOS, indicating no acute inhibitory effect on activated sludge respiration at a concentration of 1000 mg/L after 7 minutes of contact time.
|
1979 |
AR226-0877
|
5DM475e5XX1Qo0K0J2mvyGQre |
4 |
|
The document reports on an acute oral toxicity study of T-2574COC, a perfluorinated compound, conducted by Riker Laboratories, which determined an approximate LD50 between 5,000 and 1,000 mg/kg in albino rats, with significant behavioral reactions and mortality observed at the higher dosage.
|
1979 |
AR226-0294
|
QJLJRQG0Y8Xq85Dy0e4gpgw0R |
11 |
|
The document details a modified OECD 301E biodegradation test conducted on a mixture containing 0.67% perfluorooctanesulfonate (PFOS) produced by 3M in Antwerp, Belgium, indicating that the data may not accurately reflect the biodegradation potential of the fluoro-chemical component due to incompletely characterized concentrations of impurities.
|
1979 |
AR226-0889
|
ypjzJpJ0qdqgXBzB29ekJr464 |
34 |
|
The document reports on a two-week oral rangefinding toxicity study of T-2509CoC in rats, conducted by Riker Laboratories and sponsored by the EPA, which aimed to determine the acute oral ALD50 and assess the effects of the compound on various tissues.
|
1979 |
AR226-0959
|
wgyZErj0EQBXXXgmv30dMjoq4 |
30 |
|
The document details an environmental sampling study conducted by 3M in 1979 to analyze bioaccumulation of N-Ethylperfluorooctanesulfonamide (EtFOSA) in fish from the Tennessee River near a 3M fluorochemical manufacturing facility, noting the lack of standardized sampling procedures.
|
1979 |
AR226-0343
|
1QRXOYrjox60omNy5kv3nL6KZ |
36 |
|
The document reports on a 1979 study by 3M Company investigating the photodegradation of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol) in soil, concluding that no reliable results could be derived due to inadequate methodology and uncharacterized purity of the test substance.
|
1979 |
AR226-0362
|
6BLJJzyObZZGdQGGpe3XjeRX4 |
12 |
|
The document contains comments by Professor Stephen A. Boyd on the 3M Technical Report regarding the analytical methodology for FM 3422, highlighting concerns about the octanol-water partition coefficient and its implications for predicting the solubility of the compound in water.
|
1979 |
AR226-0366
|
G6Dqxxyqo7JJV9M83OkMkD82r |
3 |
|
This document details a 1979 bioaccumulation study of N-methylperfluorooctane sulfonamidoethanol (N-MeFOSE alcohol) in fish samples collected from the Tennessee River, noting the lack of standardized sampling procedures and the specific methods used for tissue analysis.
|
1979 |
AR226-0371
|
EvR047V3VDrKZzq3d1vwGBk5j |
36 |
|
The document reports on the analysis of serum samples from a Bio/Dynamics inhalation study of FC-143, focusing on the levels of organic and inorganic fluoride in male and female rats.
|
1979 |
AR226-0418
|
EvgQDDqV2bwvqB260jnE88Qx4 |
2 |
|
The document reports on a 28-day percutaneous absorption study of T-2618CoC, a perfluorinated compound, conducted on albino rabbits at Riker Laboratories, which found no significant adverse effects but indicated dermal absorption potential, although conclusive results were limited due to the small sample size.
|
1979 |
AR226-0446
|
37DpVww7JVMLExNJpvBBGq1DE |
16 |
|
The document details a bioaccumulation study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol) in fish samples collected from the Tennessee River, conducted by 3M in 1979, although it lacks specific guidelines for sampling procedures and information on the fish's capture locations.
|
1979 |
AR226-0971
|
aJMJRG53OXBzwmXaRp3w8rqyX |
37 |
|
The document reports on a bioconcentration study of N-methylperfluorooctane sulfonamidoethanol (N-MeFOSE alcohol), revealing its n-octanol/water distribution coefficients to be 52,900 and 60,600 for two test concentrations, indicating significant hydrophobicity.
|
1979 |
AR226-0972
|
XR0koQ3yGvYmpNLXre7xkVq3x |
8 |
|
The document details the synthesis and characterization of carbon-14 labeled FC-143, conducted by Riker Laboratories, Inc. for metabolism studies, reporting a specific activity of 0.507 ± 0.012 pCi/mg and a radiochemical purity of at least 98%.
|
1979 |
AR226-0456
|
da7xpw2GEYJ2N1z9VeEMYwm65 |
17 |
|
The document reports on a study conducted by S. J. Gibson and J. D. Johnson in 1979, which found significant sex differences in the excretion rates of the perfluorinated compound FC-143 (ammonium salt of a perfluorinated carboxylic acid) in male and female rats, with females excreting nearly all of the dose via urine within
|
1979 |
AR226-0457
|
JvyOdew2XBGzKjG9dkJ59YyEe |
20 |
|
The document details a 1979 study by 3M Company on the photodegradation of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol) in soil, concluding that no reliable results could be derived due to inadequate methodology and uncharacterized substance purity.
|
1979 |
AR226-0362
|
b5aa0nNE8pjDRG22gBeMRayjy |
12 |
|
The document contains comments by Professor Stephen A. Boyd on the 3M Technical Report regarding the analytical methodology and support for FM 3422, highlighting concerns about the octanol-water partition coefficient and its implications for predicting solubility in water.
|
1979 |
AR226-0366
|
embJmxnqMxrDoKBmY9LJwmJM |
3 |
|
This document details a 1979 bioaccumulation study of N-methylperfluorooctane sulfonamidoethanol (N-MeFOSE alcohol) in fish samples collected from the Tennessee River, highlighting the lack of standardized sampling procedures and the specific methods used for tissue analysis.
|
1979 |
AR226-0371
|
b9Ln4Jwnk3QXYZBdmep5jNgk |
36 |
|
The document reports on the analysis of serum samples from a Bio/Dynamics inhalation study of FC-143, focusing on the levels of organic and inorganic fluoride in male and female rats.
|
1979 |
AR226-0418
|
NEwQjYmNGxKjD9p1918G5z1aw |
2 |
|
The document reports on a 28-day percutaneous absorption study of the substance T-2618CoC conducted on albino rabbits at Riker Laboratories, Inc., which found dermal absorption but no significant adverse effects, although conclusions were limited due to the small sample size analyzed.
|
1979 |
AR226-0446
|
DMymg2r3xkbYz3ELnJX99NmDO |
16 |
|
The document details the synthesis and characterization of carbon-14 labeled FC-143, conducted by Riker Laboratories, Inc. for metabolism studies, reporting a specific activity of 0.507 ± 0.012 pCi/mg and a radiochemical purity of at least 98%.
|
1979 |
AR226-0456
|
OExrbgExjnVVEz2N9gBo790Qw |
17 |
|
The document reports on a study conducted by S. J. Gibson and J. D. Johnson in 1979, which found significant sex differences in the excretion rates of total carbon-14 from the perfluorinated compound FC-143 (ammonium salt of a perfluorinated carboxylic acid) in male and female rats, with females excreting nearly all of
|
1979 |
AR226-0457
|
NEJgOpGybG4bbYK2LQmZma7g |
20 |
|
The Haskell Laboratory Report No. 636-79 indicates that Octanoic Acid, Pentadecafluoro-, Ammonium Salt caused mild to moderate skin irritation in rabbits during a skin irritation test, suggesting that good industrial hygiene practices should be followed to minimize skin contact.
|
1979 |
AR226-2752
|
pB9OdZGBL2zx3BQ55zKG2y1Jw |
1 |
|
The document reports on aquatic toxicity studies of FM 3925, indicating that its limited water solubility prevented definitive determination of its toxicity, with both vertebrate and invertebrate LC50 values exceeding its solubility.
|
1979 |
AR226-3626
|
KGEvpremjRzzjQxNrj5Jqomz2 |
9 |
|
This report details the analysis of various perfluorocarbon polymers for residues of monomers (tetrafluoroethylene and hexafluoropropylene) and the C8-emulsifier (ammonium perfluorooctanoate) used in their production, including the determination of the specific migration of the emulsifier into distilled water.
|
1979 |
AR226-3331
|
dep7Q0mMYd1QKx0qoE8KOY9Q |
11 |
|
The document discusses the concentration levels of a C-8 fluorosurfactant in a TE-3311 dispersion produced by E.I. du Pont de Nemours & Company, indicating that measurable levels were found to be between 200 ppm and 300 ppm, with an expectation of around 1200 ppm, suggesting that some of the C-8 may be trapped within the PTFE polymer.
|
1979 |
AR226-3332
|
b5z3k7z1nrwzOEoOLzJBE9axZ |
4 |
|
This document provides an overview of ammonium perfluorooctanoate (C-8), also known as PFOA, detailing its physical properties, toxicity levels, and findings from clinical studies on occupationally exposed workers, highlighting the persistence of PFOA in human blood over time.
|
1979 |
AR226-3375
|
q6e7OJOxEMMJeJ53X62XpO0q |
6 |
|
The document reports on the determination of possible residues of C8-emulsifier, specifically ammonium perfluorooctanoate (PFOA), in various perfluorocarbon polymers, detailing the analytical methods used and detection limits achieved.
|
1979 |
AR226-3806
|
ZJyb9Na0ZOvj1LVe0g7vMRY2L |
3 |
|
The document is an analytical report from Centre Analytical Laboratories detailing the fluorochemical characterization of surface water samples collected in Decatur, Alabama, specifically analyzing for perfluorooctane sulfonate (PFOS), perfluorooctane sulfonamide (PFOSA), and perfluorooctanoate (POAA) using liquid chromatography/tandem mass spectrometry (LC/MS/MS
|
1979 |
AR226-0672
|
ZDRY315xB4da81d1o92OOJnL |
7 |
|
The document reports on an acute toxicity test of a mixture containing 0.92% PFOS (perfluorooctanesulfonate) on the aquatic invertebrate Daphnia magna, conducted in 1979, with specific details on test conditions and methodology.
|
1979 |
AR226-0798
|
91y43zX3wVEKOwgq1aaONNZj3 |
6 |
|
The document reports on an acute toxicity test of a mixture containing 0.92% PFOS (perfluorooctanesulfonate) conducted on fathead minnows (Pimephales promelas) over a 96-hour exposure period, indicating the test was not conducted under Good Laboratory Practices and involved a specific dilution series for assessing toxicity.
|
1979 |
AR226-0797
|
3RQ7Ve7dpLz5jnGYmXMYwzn3 |
7 |
|
The document details an acute toxicity test on fathead minnows (Pimephales promelas) using a mixture containing 0.92% perfluorooctanesulfonate (PFOS) from a 3M production lot, indicating the test was conducted to assess the toxicity of this fluorochemical component.
|
1979 |
AR226-0796
|
KzDKNbOkwoLXvybb8YaX0eV7x |
10 |
|
The document details a microbial inhibition test conducted on a mixture containing 0.92% perfluorooctanesulfonate (PFOS) from a 3M production lot, using activated sludge to assess the toxicity of the fluorochemical component.
|
1979 |
AR226-0799
|
gkYVjLX3E75nzxEYn8jZ56M3 |
7 |
|
The document reports on an activated sludge respiration inhibition test conducted on a mixture containing 0.92% PFOS, produced by 3M, which found no acute inhibitory effects on activated sludge respiration at a concentration of 1000 mg/L.
|
1979 |
AR226-0800
|
2qYq0Jo061jpbR8q8jMbKJqZa |
5 |
|
The document details a modified OECD Screening Test (301E) for the biodegradation potential of a mixture containing 0.67% perfluorooctanesulfonate (PFOS) produced by 3M in Antwerp, Belgium, indicating that the data may not accurately reflect the biodegradation potential due to incomplete characterization of impurities.
|
1979 |
AR226-0889
|
YjmLdpZvOY2rv4gODojL8nY6K |
34 |
|
The document details a 1978 study by 3M Company investigating the bioaccumulation of perfluorooctanesulfonate (PFOS) in bluegill sunfish exposed to effluent from their Decatur, AL plant, which indicated the presence of PFOS in the fish exposed to the effluent while no fluorochemicals were detected in the control group.
|
1978 |
AR226-0061
|
N9Mr29wkDwgaJB44ZbReBB3V |
9 |
|
The document contains a series of ecotoxicity tests conducted by Wildlife International, Ltd. on PFOS, including various acute and chronic toxicity assessments with species such as the Fathead Minnow, freshwater algae, and Eastern Oyster, completed on April 26, 2000.
|
1978 |
AR226-0081
|
xzZE9E4oRD2daR1wNOe8aVvOE |
3 |
|
This document summarizes a 1981 toxicity study conducted by 3M Company on perfluorooctanesulfonate (PFOS) using the aquatic plant species Selenastrum capricomutum, reporting nominal EC50 values but noting issues with sample purity and statistical reliability.
|
1978 |
AR226-0106
|
gaK1ZdrGGbZNRV216v8qdY6ja |
18 |
|
This research report submitted to 3M Company examines the effects of continuous aqueous exposure to 14C-78.02 on the hatchability, growth, and survival of fathead minnow (Pimephales promelas) eggs and fry, finding that survival was the most sensitive indicator of toxicity with an estimated MTC value between >1.0 mg/L and <1.9 mg/L
|
1978 |
AR226-0108
|
zQ4bOD2oOVprdXrJ8qqJb4YX7 |
29 |
|
The document reports that in vitro microbiological mutagenicity assays conducted by SRI International on 3M Company compounds T-2247 CoC and T-2248 CoC found no mutagenic or recombinogenic activity in various strains of Salmonella typhimurium and yeast.
|
1978 |
AR226-0134
|
Gmx9Jb3w3jo4k07Dx23MzQLbn |
22 |
|
The document outlines a ninety-day subacute rat toxicity study conducted by the International Research and Development Corporation on the fluorochemical surfactant FC-95, sponsored by 3M Company, to assess its safety and biological effects.
|
1978 |
AR226-0139
|
ZJKnoKKNey7xBMajpxqy3E32p |
55 |
|
The document details a bioconcentration study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol) using channel catfish to determine its aquatic bioconcentration factor, following a 3M derived method, although specific details on fish size, loading, and water chemistry are not provided.
|
1978 |
AR226-0352
|
NGrkBkbzbMvnMg50D6OR1bGkb |
7 |
|
The document details a 1978 study by 3M Company investigating the bioaccumulation of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE Alcohol) in bluegill sunfish exposed to effluent from their Decatur, AL plant, finding 7 ppm of the substance in the effluent-exposed fish while none was detected in
|
1978 |
AR226-0354
|
JrrJvLBMX8d0axa0X45qBm8dZ |
10 |
|
The document reviews the findings from 3M Technical Notebook No. 48277 regarding soil thin layer chromatography of perfluorinated compounds FC 143 and FM 3422, indicating that the method is insensitive and suggesting that mobility studies should be conducted using soil columns for more reliable data.
|
1978 |
AR226-1030
|
NG3a15gq8YraK24RGE64RrGVb |
3 |
|
The document reports on an acute oral toxicity study of the test material FM-3422, produced by 3M Company, which found LD50 values of 1615 mg/kg for male rats and 1333 mg/kg for female rats.
|
1978 |
AR226-0979
|
kYqLwoNRVVOZaYwbxzbYbnkn |
13 |
|
The document outlines a protocol for a Rat Teratology Study (Segment II) to assess the embryo/fetal toxicity and teratogenic potential of the test material T-3352, administered to pregnant rats during fetal organogenesis, in compliance with FDA guidelines.
|
1978 |
AR226-0979
|
Znv32VY06Epwyjq22rV1jZMyL |
13 |
|
The document contains comments from Professor Stephen A. Boyd of Michigan State University on a 3M Technical Report regarding soil thin layer chromatography of perfluorinated compounds FC 143 and FM 3422, indicating that the method used is insensitive and does not provide useful information due to the similar behavior of the compounds despite their differing soil sorption coefficients.
|
1978 |
AR226-1030
|
DGOXXLkM48XDOzrDbXErGM2vd |
3 |
|
This document reports on a 1978 study by 3M Company that developed a Thin Layer Chromatography method to assess the soil mobility of ammonium perfluorooctanoate (PFOA ammonium salt), concluding that it likely adsorbs to soil and does not move from its application spot.
|
1978 |
AR226-1030
|
M49odL1kpeObB7MGZOkLmKd17 |
2 |