|
3M Company submitted studies to the EPA on May 23, 2003, regarding exploratory 28-day oral toxicity studies of various perfluorinated compounds, indicating that the data may warrant Section 8(e) submission due to potential implications for previously reported information.
|
2003 |
AR226-3656
|
jN4VomGXNQkG75ajj5VMDQrp |
3 |
|
3M Company submitted studies related to perfluorinated compounds to the EPA under TSCA Section 8(e), indicating that the data may not corroborate previously reported information and includes a master index of the studies.
|
2003 |
AR226-3657
|
x53wkyGwVEZzKqpj2MnOKDkEy |
19 |
|
The document details a study conducted by White Eagle Toxicology Laboratories on the dermal sensitization of a test article identified as H-21891, sponsored by E.I. du Pont de Nemours and Company, using the modified Buehler method in guinea pigs.
|
2003 |
AR226-3055
|
v102z7YBO8X7xZNENEN56vbrY |
87 |
|
The document is a final report of a reproduction study conducted by Wildlife International, Ltd. on the Northern Bobwhite, sponsored by 3M Corporation, which adhered to Good Laboratory Practice standards and aimed to assess the effects of potential contaminants, including PFOA and PFOS, on avian reproduction.
|
2003 |
AR226-3748
|
X7Vd5pOpX4OZ53qv9OeqZwxr4 |
444 |
|
This document appears to be a DuPont internal report discussing the fluorotelomer supply chain and its status as of December 15, 2003, but contains no analytical content due to extensive sanitization.
|
2003 |
AR226-3323
|
JNEoo19x5DEEVELr5g178qDJB |
37 |
|
The document summarizes presentations by DuPont at the SETAC Europe conference regarding the biotransformation of the fluorotelomer 8-2 Telomer B Alcohol, highlighting its potential environmental persistence and metabolic pathways for further transformation into other fluorinated species.
|
2003 |
AR226-3343
|
YrMRnk7B70LGdnor5v41yzkbD |
2 |
|
The document summarizes presentations from the Society of Environmental Toxicology & Chemistry regarding the development of analytical methodologies for determining Telomer B alcohols and Telomer-derived fluorosurfactants and polymers, focusing on challenges in analyzing these substances in environmental matrices using techniques like GC-MS and LC-MS.
|
2003 |
AR226-3348
|
xdv8GyqR4VzBNwEbJxVBkwDEJ |
2 |
|
The document discusses the physicochemical properties of fluorotelomer alcohols, specifically their vapor pressure and water solubility, which are crucial for understanding the environmental fate of these compounds, including 8-2 Telomer B alcohol used in manufacturing fluorinated surfactants and polymers.
|
2003 |
AR226-3355
|
nmaYZM38Dzkj6QEr94xObrRXa |
1 |
|
The document is a submission to the EPA's IRIS and AR-226 database regarding PFOA and PFOS, including additional information from a study titled "Emerging Contaminants in Cape Cod Drinking Water" by Schaider et al., aimed at contributing to the EPA's review of these perfluorinated compounds.
|
2003 |
AR226-3932
|
dJ9ZQYyevBrgavGN6ZnomnGb |
41 |
|
The document is a submission to the EPA's IRIS and AR-226 database regarding PFOA and PFOS, including a customer flyer on test results from the New Castle, Delaware, Municipal Services Commission.
|
2003 |
AR226-3941
|
aB1jmDEoz9mbbDp013bkoOMre |
23 |
|
This document is a submission by Robert A. Bilott to the EPA's IRIS and AR-226 database regarding PFOA and PFOS, including additional information from two studies on the accumulation and clearance of PFOA and its effects on puberty patterns among children in the Mid-Ohio Valley.
|
2003 |
AR226-3946
|
evEM0ogroykzGL7L5DmzyDOy9 |
1 |
|
This document is a submission to the EPA's Integrated Risk Information System (IRIS) and AR-226 database regarding PFOA and PFOS, including a reference to a study on private drinking water wells as a source of PFOA exposure in communities near a fluoropolymer production facility.
|
2003 |
AR226-3949
|
RpLnVYdbNyXYzp8KQNm1wdqJB |
1 |
|
This is a letter from Taft Stettinius & Hollister LLP dated August 4, 2010, submitting additional information to the EPA's IRIS and AR-226 databases regarding PFOA/PFOS, including a review of perfluorooctanoic acid carcinogenicity.
|
2003 |
AR226-3955
|
37rGV0m3KxqKODXenQxxLxky0 |
70 |
|
This document is a submission to the EPA's IRIS and AR-226 database regarding PFOA and PFOS, including additional information from a public health assessment by the Minnesota Department of Health and a doctoral thesis on the effects of perfluorinated compounds on steroidogenesis.
|
2003 |
AR226-3953
|
O3LEEzR6RYe65XQE0Dj0YxXw1 |
113 |
|
This analytical report from Centre Analytical Laboratories details the characterization of water and sediment samples for perfluorinated compounds, specifically analyzing for PFOS, PFOSA, and POAA as part of 3M Project E00-2003 from Port St. Lucie, Florida.
|
2003 |
AR226-0676
|
2jJkw3mr7Qbd14DL04emv1GLb |
9 |
|
3M submitted data on perfluorooctane sulfonates, including results from bacterial mutation and chromosome aberration tests, to the EPA as part of their ongoing dialogue regarding fluorochemicals.
|
2003 |
AR226-1199
|
rBpdwVrxR9wBO3OQGrg8MoEka |
1 |
|
DuPont submitted a study report on commercially available cookware to the EPA for inclusion in Administrative Record 226, detailing previously presented comments regarding the presence of perfluorinated compounds.
|
2003 |
AR226-1203
|
EvYpZaDE19brb2rQw1vyVMnLn |
1 |
|
3M submitted a supplemental report to the EPA detailing new findings from a study on perfluorooctane sulfonate (PFOS) that indicated a statistically significant effect on mean pup body weight per litter at a maternal treatment level of 0.4 mg/kg/day, with a defined dose-response relationship.
|
2003 |
AR226-1205
|
KJ14b7NbNjw54vKr45p4qNYxK |
1 |
|
3M submitted a final report on a pharmacokinetic study of potassium perfluorooctanoate to the EPA as part of their ongoing dialogue regarding perfluorinated compounds.
|
2003 |
AR226-1227
|
O17aJw915KLOgYbvGDre6eYnL |
1 |
|
This is a letterhead cover page from Clariant, with no analytical content retained in the OCR.
|
2003 |
AR226-1247
|
VJVY47rJNbLvjNM8moeNjwpVN |
1 |
|
This document is a letter from DuPont detailing the manufacturing locations of their telomer-based products in the United States, specifically related to the characterization of potential PFOA release as part of their Voluntary Commitment to the EPA.
|
2003 |
AR226-1260
|
ZJbYxrrR5Rax0pEyv87M9p9j0 |
1 |
|
The document is a letter from DuPont's Stephen H. Korzeniowski to the EPA's Mary Dominiak, providing information on the Telomer manufacturing process related to the potential release of PFOA as part of the Telomer Research Program's voluntary commitment.
|
2003 |
AR226-1265
|
k9B0O4029zOKpzMqeJYeLZp30 |
1 |
|
The document is a letter from DuPont's Stephen H. Korzeniowski to EPA's Mary Dominiak, providing information on biodegradation screening and method development studies related to the 8-2 Telomer Alcohol product as part of the Telomer Research Program, in compliance with a voluntary commitment to the Agency.
|
2003 |
AR226-1261
|
Qkd6yQ5JoymMzNykn2Vy3Nz2L |
1 |
|
Dyneon LLC provided the EPA with a list of its U.S. manufacturing site in Decatur, Alabama, where it produces fluoropolymers using APFO (CAS No. 3825-26-1), as part of its commitments in the PFOA Users Letter of Intent dated March 14, 2003.
|
2003 |
AR226-1270
|
x1Bwp9BJj8Qg1wBaqk13YKj5J |
1 |
|
The document is a submission from Katie Smythe on behalf of the Telomer Research Program to the U.S. EPA, providing two journal articles for inclusion in Administrative Record 226, one on PFOS levels in Japan and another on PFOA levels in the blood of Japanese people.
|
2003 |
AR226-1277
|
pR765Y6gxbNL0Vpnb32RLQ2k |
1 |
|
The document is a final study report submitted to the EPA's AR-226 administrative record regarding perfluorinated compounds, specifically addressing findings related to a telomer research program.
|
2003 |
AR226-1275
|
v6a81z26b89nOE7ZxY6oM5N6m |
1 |
|
The document is a communication from Katie D. Smythe of the Telomer Research Program to Mary F. Dominiak at the EPA, providing draft study plans for analyzing PFOA in telomer-based products and treated articles, along with guidance for sampling procedures, and requesting comments by February 28.
|
2003 |
AR226-1271
|
jB9VO5K8Lk593Lp6n05eK6p8N |
1 |
|
This document is a progress report submitted by Katie Smythe on behalf of the Telomer Research Program to the U.S. EPA, detailing Year 1 findings from the University of Toronto's research on fluorotelomer alcohols, with no confidential business information included.
|
2003 |
AR226-1280
|
RdoyGJyLLeJBrbLB4oo3LznV |
1 |
|
The document is a submission from the Telomer Research Program to the EPA, outlining the scope and rationale for a study on "Analysis of Telomer-Based Products and Telomer-Treated Articles," which is part of their Voluntary Commitment regarding perfluorinated compounds.
|
2003 |
AR226-1284
|
VJBLvMjx9g9Z0gnmxeYabwgV4 |
1 |
|
The document is a submission from Katie Smythe on behalf of the Telomer Research Program to the EPA, detailing the scope and rationale for the "8-2 Telomer B Alcohol Biodegradation Research" as part of ongoing TRP research activities.
|
2003 |
AR226-1282
|
aDxqonaQqOw3nwdYnydBVMBpN |
1 |
|
The document is a submission from Katie Smythe on behalf of the Telomer Research Program to the EPA, providing study reports on 8-2 Telomer B Alcohol (CAS# 678-39-7) for inclusion in Administrative Record 226, confirming that none of the files contain Confidential Business Information.
|
2003 |
AR226-1286
|
kmxkxxxqXQvzXznX8dV6dKw8D |
1 |
|
The document is a submission from the Telomer Research Program to the EPA, providing a list of documents related to telomers, including studies on physical-chemical properties, toxicology, and environmental effects, with a commitment to submit the actual documents by April 15, 2003.
|
2003 |
AR226-1291
|
LJMGGRRGeynmK4q5Z7ZnbrpnQ |
1 |
|
The document is a submission to the EPA's AR 226 regarding the mechanics of film formation of aqueous film-forming foam (AFFF) fire fighting agents, including attached presentations and papers related to the fluorosurfactants in AFFF, provided by Tom Cortina of the Fire Fighting Foam Coalition.
|
2003 |
AR226-1312
|
Vjg4EbOGz0YjKXOMNv422qEKg |
1 |
|
The memorandum summarizes a March 14, 2003 meeting between EPA officials and the Environmental Working Group, where concerns were raised about the hazards, exposures, and risks of PFOA and PFOS, including their widespread presence in humans and potential environmental degradation from telomer alcohols.
|
2003 |
AR226-1310
|
rzY1r0gyMRjXgM8MD5JJM7JG |
1 |
|
This is a letterhead cover page from DuPont, with no analytical content retained in the OCR.
|
2003 |
AR226-1316
|
rBMnn52RyDekjkmnemepqoEZa |
1 |
|
This document is a submission from 3M to the EPA regarding the final reports of three ecotoxicity studies on triphenylbenzyl phosphonium cation/N-methyl perfluorooctanesulfonamide salt (TPBP C8 amide), confirming results consistent with previously reported information.
|
2003 |
AR226-1334
|
nkQYLbE2aZdXq9nxLbgG45b8R |
1 |
|
This is a document submission from Katie Smythe on behalf of the Telonrer Research Program, although the specific analytical content is not retained in the OCR.
|
2003 |
AR226-1338
|
zoQnNLrgbJ5BDBpVBogE2eMXa |
1 |
|
This is a document submission from the Telomer Research Program, prepared by Katie Smythe, regarding unspecified analytical content.
|
2003 |
AR226-1343
|
KRqNX8oxXGvKrR4VXEwRab6G6 |
1 |
|
The document reports on an acute oral toxicity study of 8-2 Telomer B Alcohol conducted by DuPont, indicating no clinical signs of toxicity at the tested doses.
|
2003 |
AR226-1344
|
6bzvGGOxNjXnNGny8qK8NGkq1 |
1 |
|
The document is a request for comments and solicitation of interested parties by the EPA regarding potential human health concerns about Perfluorooctanoic Acid (PFOA) as part of the development of enforceable consent agreements for additional data production.
|
2003 |
AR226-1418
|
jmq9joLD4qYO62o3x84xd4oV2 |
1 |
|
The document is a submission from Katie Smythe on behalf of the Telomer Research Program, including study reports on 8-2 Telomer B Alcohol, detailing toxicity tests on earthworms, nematodes, and terrestrial plants for inclusion in the EPA's administrative record.
|
2003 |
AR226-1427
|
nkGqxKRNy56MbemnBORVwZORm |
1 |
|
The document is a submission from Katie Smythe on behalf of the Telomer Research Program, detailing study summaries on the acute hazard of 8-2 Telomer B Alcohol (C8F17CH2CH2OH) for inclusion in the EPA's Administrative Record 226, which includes findings from tests conducted on various freshwater aquatic species.
|
2003 |
AR226-1419
|
QJxYdykGgO7Q6vymx6gYGk8yE |
1 |
|
This document is a letter from Robert A. Bilott to Richard H. Hefter at the EPA, providing a C-8 blood model developed by DuPont related to estimated levels of perfluorooctanoate (PFOA) concentrations in the blood of communities exposed to DuPont's emissions.
|
2003 |
AR226-1477
|
LJjR35JKBYrbGZee2OmRab8B3 |
1 |
|
This is a map detailing monitoring points for the 3M Cottage Grove Facility, including new monitoring wells, production wells, and other sampling points.
|
2003 |
AR226-1483
|
rBz89Y1va46yvKKzoOX7kYnVr |
1 |
|
3M submitted an electronic copy of their "Environmental and Health Assessment of Perfluorooctane Sulfonic Acid and its Salts" to the EPA, which integrates available data regarding PFOS.
|
2003 |
AR226-1485
|
rB4pqngwVZadMgLMvxwqz4yEq |
1 |
|
The document is a cover letter from Gary W. Jepson of DuPont, enclosing a report on the toxicokinetics of perfluorooctanoic acid (PFOA) in rats, sponsored by the Association of Plastics Manufacturers of Europe Fluoropolymers Committee, addressed to Dr. Oscar Hernandez at the EPA.
|
2003 |
AR226-1498
|
rpm6LppbL8Kvj3nn6gnVZB4O7 |
1 |
|
The document discusses the fluorosurfactants used by Ansul Corp. in the production of Military Specification AFFF, confirming that two fluorosurfactants were present in the Ansulite A FC-5A and 5 products supplied in the 1980s.
|
2003 |
AR226-1518
|
0J9j6Z6yyvYEMj1N29ao62jZM |
1 |
|
The document is a submission from the Telomer Research Program, representing companies including Asahi Glass, Clariant, Daikin, and DuPont, to the EPA, providing a study report on the atmospheric fate of fluorinated alcohols for inclusion in the administrative record on PFOA/PFOS.
|
2003 |
AR226-1519
|
ppqNZpZLk82ndQrKJMQ549r6k |
1 |
|
3M submitted a final report on a toxicity study of perfluorooctanesulfonate (PFOS) to the EPA, confirming preliminary results previously reported in 2000.
|
2003 |
AR226-1526
|
82qbMY6O4x0ZK6qoBVyMYRgRZ |
1 |
|
The document is a submission from 3M to the EPA regarding the final report of a 28-day oral toxicity study in rats for the chemical 1-Butanesulfonylfluoride, 1,1,2,2,3,3,4,4-octafluoro-4-[(trifluoroethenyl)oxy] (CAS: 881
|
2003 |
AR226-1524
|
wr18Gg6avyarO9ggvBEKaJex6 |
1 |
|
The document is a cover letter from Ann K. Masse of DuPont, submitting a report titled "DuPont Telomer Manufacturing Sites: Environmental Assessment of PFOA Levels in Air and Water" to the EPA, which addresses PFOA levels related to DuPont's manufacturing operations in West Virginia and New Jersey.
|
2003 |
AR226-1533
|
kaQJJOYmm9Ob7Ea9gY2OvyL8b |
1 |
|
This letter from DuPont provides additional information regarding the active ingredient in Zonyl FSP Fluorosurfactant, which contains perfluorinated compounds used in cleaning products, and includes guidance on safe use and disposal procedures.
|
2003 |
AR226-1535
|
gDG9jD6JyYYQ0njd77QgMzXJa |
1 |
|
The document is a submission of a study report on the biodegradation of 14C-labeled 8-2 Telomer B Alcohol by the Telomer Research Program, which includes companies like DuPont and Daikin Industries, to the EPA for inclusion in the administrative record, with a request for the report to be restricted to "read-only" status until a related manuscript is published.
|
2003 |
AR226-1639
|
VKOn56XVxvEow8RMV33r5Xwdj |
1 |
|
The document is a submission from Katie Smythe on behalf of the Telomer Research Program, including member companies such as DuPont, to the EPA, providing a study report on the ecotoxicity of C8-2 alcohol based on a 21-day Daphnia magna reproduction test.
|
2003 |
AR226-1642
|
b5JNVLmO1RXjzz2pRKy6x3JOo |
1 |
|
This is a cover letter addressed to the USEPA regarding fluorochemical submissions, with references to toxicology, epidemiology, and environmental studies.
|
2002 |
AR226-1051
|
x5rJzDDkR9JXv0LvzeaZrzQg |
1 |
|
The document is a bibliography of studies related to perfluorooctanesulfonate (PFOS) and N-ethyl perfluorooctane sulfonamide (N-EtFOSA), highlighting various research findings on their environmental distribution, toxicology, and analytical methods.
|
2002 |
AR226-1051
|
6BVdBVkn4X0YaDwoz7RY92Q61 |
3 |
|
3M Specialty Materials submitted a compact disc to the EPA containing new study reports and analytical data on perfluorooctane sulfonates and related compounds, continuing their voluntary data sharing on fluorochemicals as part of an ongoing dialogue with the agency.
|
2002 |
AR226-1051
|
3NQYVRQB45b31N2QXgqrrvexJ |
2 |
|
The document contains environmental studies and ecotoxicity reports related to PFOS and PFOA, including acute toxicity tests on rainbow trout and sheepshead minnows, as well as a lifetime drinking water health advisory for PFOA from 3M.
|
2002 |
AR226-1051
|
R8kvYLXnLwMKx9wBKyN4k2Ek |
1 |
|
This document details various toxicology and epidemiology studies conducted by 3M on perfluorooctanesulfonate (PFOS), including a 26-week study in monkeys and a 104-week dietary chronic toxicity and carcinogenicity study in rats, along with associated analytical laboratory reports.
|
2002 |
AR226-1051
|
OEy3gbZYLBrdOrMZab3yLajoM |
2 |
|
The document outlines 3M's Lifetime Drinking Water Health Advisory for perfluorooctanoate (PFOA), establishing a reference dose of 2 ug/kg-day based on animal studies, leading to a calculated drinking water exposure level of 70 ug/L and a lifetime advisory level of 14 ug/L for community exposure considerations.
|
2002 |
AR226-1051
|
pm8Y9Va0w5OQ9bRM9LMJ2E6ba |
14 |
|
The document is a final report on a 26-week capsule toxicity study of Perfluorooctane Sulfonic Acid Potassium Salt (PFOS) conducted on Cynomolgus monkeys by Covance Laboratories for 3M, indicating compliance with EPA Good Laboratory Practice regulations except for one analysis.
|
2002 |
AR226-1051
|
nkgq4nr7ObVr98BNjBz4X2xZ8 |
1086 |
|
The document is a submission to the EPA regarding a fluorosurfactant formulation used in the production of AFFF (aqueous film-forming foam) agents, provided by an unnamed company in cooperation with the Fire Fighting Foam Coalition, and includes confidential business information.
|
2002 |
AR226-1045
|
N2zD7N74Zz0y3QEKO4Nz0q8xp |
2 |
|
3M is submitting additional data on perfluorooctane sulfonates and related compounds to the EPA, including new study reports and a bibliography, as part of their ongoing dialogue regarding fluorochemicals.
|
2002 |
AR226-1051
|
EqqMZ3J3ORrXbogyNwkY34OJN |
8 |
|
The document summarizes a study on the toxicity of Ammonium Perfluoro-octanoate (APFO) conducted on Cynomolgus monkeys, revealing signs of liver and muscle toxicity at higher doses, with a specific incident of morbidity in the 3 mg/kg group, and overall findings indicating a dose-dependent increase in liver weight without clear pathological changes at lower doses.
|
2002 |
AR226-1053
|
Em8eRjRvrJ8kknDMrbbJp9vkn |
26 |
|
This is a cover page for a Fluoropolymer Manufacturers Group meeting, with no analytical content retained in the OCR.
|
2002 |
AR226-1054
|
EmdqjjRmD7j2jYBk8amb4y6Ox |
2 |
|
This document summarizes studies sponsored by 3M regarding the occurrence of perfluorooctanoate (PFOA) in environmental, dietary, and human samples, concluding that PFOA is not broadly dispersed in the environment and is typically found at low concentrations, with specific findings of PFOA detected in 18 out of 31 mink livers from Massachusetts.
|
2002 |
AR226-1055
|
JJ7pg1zZmEjm8Z1gnwmm3ERa6 |
17 |
|
The document reports the results of an acute inhalation toxicity study conducted on a mixture of perfluorinated compounds, including ammonium salts, which revealed high mortality rates in rats exposed to higher concentrations, indicating significant toxicity.
|
2002 |
AR226-1057
|
ZXBBk25L5wG2Z9QxEgergr8p |
1 |
|
The document contains comments from Rich Purdy regarding the Telomer Research Plan, specifically questioning the choice of the 8:2 telomer alcohol for testing due to its rapid metabolism to PFOA and highlighting potential deficiencies in the research approach.
|
2002 |
AR226-1058
|
gaGK369OdV4e2zgR0LzqgN1aV |
3 |
|
The Fire Fighting Foam Coalition provided the EPA with information regarding the chemistry and quantity of fluorosurfactants, specifically noting that approximately 138,000 pounds of these substances were used in the production of aqueous film-forming foam (AFFF) agents in the U.S. in 1999, primarily focusing on telomer-based AFFF agents.
|
2002 |
AR226-1065
|
89dqpKRox8aKVgBgg4LQnrZ5 |
1 |
|
The document is an updated submission from DuPont regarding the Telomer Research Program, which includes a withdrawal of the confidential business information claim for specific pages and corrections to a typographical error, intended to replace a previous version in the EPA's public record.
|
2002 |
AR226-1066
|
3JOLymn14oZbj61dwGDoBQ8JD |
34 |
|
The document is a submission from DuPont Haskell regarding the inclusion of a report titled "K-24921: Dermal Sensitization Test Buehler Method" in the AR226 and TSCA Section 8 FYI files, confirming that it contains no trade secrets or confidential business information.
|
2002 |
AR226-1067
|
82qadN6zDJ22MZLd9BOXVEXyd |
26 |
|
3M submitted a final report on a 2-year rat feeding study of N-ethyl perfluorooctanesulfonamidoethanol (CASRN 1691-99-2) to the EPA, indicating that liver effects and increased thyroid and hepatocellular adenomas were observed at the 100 ppm dose level.
|
2002 |
AR226-1068
|
XRkRGE21y83mJ88Q7dgkGNLMJ |
2 |
|
The document is an updated submission from DuPont to the U.S. EPA regarding a presentation on PFOA, clarifying that certain previously claimed confidential business information is now public and providing revised timelines and study material names.
|
2002 |
AR226-1069
|
v1GEVjx5D80NQdr3zVKdbv7zY |
36 |
|
3M submitted a final report from Covance Laboratories detailing a 2-year rat feeding study on potassium perfluorooctanesulfonate (PFOS), which found increased liver toxicity and hepatocellular adenoma incidence in male rats at higher doses.
|
2002 |
AR226-1070
|
VG9qR1ZZew7jY2Yy5RoMnQno4 |
3 |
|
The document discusses the EPA's publication of a Final Rule and a Supplemental Proposed Rule regarding the regulation of 13 discontinued perfluoroalkyl sulfonate (PFAS) chemicals and 75 additional chemicals, requiring significant new use notices for their manufacture or import after December 31, 2002, while clarifying the terminology used for PFAS and PFOS.
|
2002 |
AR226-1072
|
Ne9Nm8kkKVqNvMjoQJQM9pmLD |
2 |
|
This is a letter from the Fire Fighting Foam Coalition, signed by Executive Director Thomas A. Cortina, addressing Mr. Auer regarding issues related to firefighting foam and its environmental impact.
|
2002 |
AR226-1075
|
9JgJE6jBVRjmL0vxkLpx0z3OV |
1 |
|
The document is a memorandum from the EPA discussing a Draft Hazard Assessment of Perfluorooctanoic Acid (PFOA) and its salts, indicating that PFOA may present environmental and health concerns similar to PFOS, including persistence, potential bioaccumulation in humans, and carcinogenic effects in animals, while noting that further studies are still pending.
|
2002 |
AR226-1077
|
j2yoq8d4ZXXNkeaDdmZN6D0Q |
2 |
|
The document is a draft hazard assessment of Perfluorooctanoic Acid (PFOA) prepared by the EPA, indicating that PFOA may present environmental and health concerns similar to those of PFOS, including persistence, potential bioaccumulation in humans, and carcinogenic effects in animals, while noting that further reproductive study data are still pending.
|
2002 |
AR226-1078
|
YGxqn8qLoZ2yQrNDVvwp7b69V |
2 |
|
3M submitted a TSCA 8(e) supplemental notice to the EPA regarding draft reproduction studies on Perfluorooctanesulfonate (PFOS) in northern bobwhite and mallard ducks, indicating that while higher feed levels caused toxicity, the 10ppm group showed no adverse reproductive effects compared to controls.
|
2002 |
AR226-1080
|
gDgqmx8g05a9w7E88ODMEb3Q |
2 |
|
The document reports that the EPA has reached a consent agreement with DuPont regarding a plan to supply drinking water in response to concerns related to perfluorinated compounds.
|
2002 |
AR226-1076
|
7RqXKjz1o8oEVj6eByNVKNdno |
50 |
|
3M submitted a TSCA 8(e) substantial risk notice to the EPA regarding Ammonium Perfluorooctanoate (APFO), CAS#: 3825-26-1, highlighting statistically significant adverse effects observed in a reproduction study in rats, including decreased lactation index and delays in sexual maturation, while noting that further analysis is needed to determine causation.
|
2002 |
AR226-1081
|
J3GOQ7wrjbgRmdngBEGQjkpvZ |
1 |
|
3M submitted a TSCA Section 8(e) Supplemental Notice to the EPA, providing final reports on the identification of fluorochemicals, including PFOS and PFOA, in human sera and their serum half-lives, to facilitate access to previously notified information.
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2002 |
AR226-1082
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dY483zjdqqzXav7YOgpwNjLnG |
2 |
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The document is a final report from 3M Company detailing a study that analyzed 645 serum samples from American Red Cross adult blood donors for the presence of fluorochemicals, finding a geometric mean concentration of PFOS at 34.9 ppb.
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2002 |
AR226-1083
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G51a8nEz2KeL0EeZVR8qLEZmx |
39 |
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The document is a final report from 3M Company detailing the identification and quantitative analysis of various fluorochemicals, including PFOS and PFOA, in serum samples from elderly participants in a cognitive function study in Seattle, with a reported geometric mean concentration of PFOS at 31.0 ppb.
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2002 |
AR226-1084
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N2o0MDX0B6vrn28jnRr2mkG0D |
31 |
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The document is a final report from 3M Company detailing a study that analyzed serum samples from pediatric participants in a clinical trial for group A streptococcal infections to characterize the distribution of seven fluorochemicals, including perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA).
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2002 |
AR226-1085
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O37b7NdoVpOdQL2R2gr3z3xDe |
48 |
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This interim report from 3M Company details an ongoing study to determine the serum half-lives of PFOS and PFOA in human retirees from fluorochemical production plants, indicating a likely serum half-life of PFOS between 139-640 days and PFOA around one year, while addressing previous methodological concerns raised by 3M in correspondence with the U.S. EPA.
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2002 |
AR226-1086
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37DOprevo9gjoM899vQn0jED6 |
22 |
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This document discusses the benchmark doses for tumors in Sprague Dawley rats fed N-Ethyl Perfluorooctanesulfonamido Ethanol (N-EtFOSE), highlighting the calculation of the benchmark dose lower confidence limit (BMDL) for cancer risk assessment based on bioassay data.
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2002 |
AR226-1089
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omj8kx5opbqEdddVgKyqK249D |
4 |
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The document discusses the benchmark dose (BMD) for liver tumors in Sprague Dawley rats fed Perfluorooctane Sulfonic Acid Potassium Salt (PFOS), detailing the methodology for calculating the BMDLio and its implications for cancer risk assessment.
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2002 |
AR226-1090
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Vr0DDYoaNd9wxn3qzYKj6z0w |
4 |
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3M submitted a final report to the EPA regarding a two-generation reproduction study in rats on Ammonium Perfluorooctanoate (CAS# 3825-26-1) as part of their TSCA 8(e) substantial risk notification.
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2002 |
AR226-1091
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kDngZVVnnDrKkzEqNpGKVGx5D |
1 |
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The document is a draft hazard assessment by the EPA evaluating the potential health and environmental hazards associated with perfluorooctanoic acid (PFOA) and its salts, focusing on toxicology data, including a two-generation reproductive toxicity study of ammonium perfluorooctanoic acid (APFO) and related compounds.
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2002 |
AR226-1079
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6BgbnD3Bnvzm8mQ6r33VneOyo |
339 |
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The document is a letter from the Society of the Plastics Industry, Inc. to the EPA, providing presentation slides from the Fluoropolymer Manufacturers Group regarding PFOA, including discussions on risk assessment, environmental distribution, exposure routes, and industry efforts to minimize environmental impact.
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2002 |
AR226-1094
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DaYmG5zGaewJ7GX1rZq80124 |
34 |
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The document is a communication from the EPA regarding a corrected version of the Draft Hazard Assessment of Perfluorooctanoic Acid (PFOA) and its salts, which includes an error in the original text that has been rectified.
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2002 |
AR226-1093
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ZJpJEZKrbo7yoGExpoKZQqxLp |
82 |
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3M submitted additional data to the EPA regarding perfluorooctane sulfonates, including a final report on a two-generation reproduction study of ammonium perfluorooctanoate in rats, which analyzes the effects of gestational age and body weight on reproductive outcomes.
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2002 |
AR226-1095
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baRG5pYnb6JxL2LdLm0ZyMbNO |
1 |
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The document discusses the covariant analysis for study 418-020 related to sexual maturation in rats, focusing on the effects of gestational age and body weight as covariates, in the context of research conducted by Charles River Laboratories for 3M, potentially involving perfluorinated compounds.
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2002 |
AR226-1096
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vVQbBOY4xBy1rV5Xk4mBy2B0Z |
22 |
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3M submitted a TSCA 8(e) substantial risk notice to the EPA regarding a rat study on triphenylbenzyl phosphonium cation/N-Methyl perfluorooctanesulfonamide salt, indicating significant toxicity at higher doses and identifying a No Observable Adverse Effect Level (NOAEL) at 5 mg/kg.
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2002 |
AR226-1097
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ykdZdEByjoEmbDBmdwVRkZ59n |
1 |
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3M submitted a series of reports and data to the EPA regarding perfluorooctane sulfonates (PFOS) and related compounds, including toxicity studies and health advisories, as part of their ongoing dialogue about fluorochemicals.
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2002 |
AR226-1100
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n9gDLmZGpzR9rRRLv20xE2qgw |
2 |
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The document is a response from the EPA regarding a request for medical monitoring of firefighters exposed to PFOS in firefighting foam, noting that 3M was the sole producer of PFOS-based foam and has ceased production, while the EPA continues to investigate other fluorinated compounds.
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2002 |
AR226-1099
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xz45mYG4gmMBMGvaVk8x53M0m |
13 |
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The Toxikon final report indicates that Ammonium Perfluorooctanoate (PFOA) did not induce mutations in the CHO/HGPRT forward mutation assay, showing no significant increase in mutant colonies compared to negative controls.
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2002 |
AR226-1101
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2qpOkYKOQwEZkJ5QodKxZQb7R |
29 |
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This document establishes a Lifetime Drinking Water Health Advisory (DWHA) of 4 pg/L for perfluorooctanesulfonate (PFOS), based on EPA methodology and assumptions regarding water consumption.
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2002 |
AR226-1105
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6K5OqXxeBaEYoaVvjj6vdze6 |
6 |
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The document is an analytical report from 3M Environmental Laboratory detailing the determination of the presence and concentration of Perfluorooctane Sulfonate (PFOS) in serum and liver samples of Cynomolgus monkeys as part of a medical department study (T-6295.22) completed on May 3, 2002.
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2002 |
AR226-1103
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6E0OvwZ6QNGq3dG0XgEMakO4 |
113 |