|
This document details a biodegradation study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol), produced by 3M, using activated sludge from a wastewater treatment plant to assess its degradation under aerobic conditions, following EPA guidelines.
|
2000 |
AR226-1030
|
9JznQr3d4jOLXyEG4Oe0maopR |
4 |
|
This document details an 18-day aerobic biodegradation study of perfluorooctanesulfonate (PFOS), produced by 3M, using activated sludge from a wastewater treatment plant, with a reported purity of 97.9%.
|
2000 |
AR226-1030
|
RJ43x4ZRyx1YrQEo93Mrp1wbz |
3 |
|
This document details a biodegradation study of N-ethylperfluorooctane sulfonamidoethanol (N-EtFOSE alcohol), produced by 3M, conducted under aerobic conditions to assess its degradation potential using activated sludge from a wastewater treatment plant.
|
2000 |
AR226-1030
|
1oo3J943mnK6J3j0VdG7XLLo |
3 |
|
The document reports on a stability test for perfluorooctanesulfonate-potassium salt (PFOS) conducted by 3M, which found no evidence of direct or indirect photolysis degradation under various light exposure conditions.
|
2000 |
AR226-1051
|
8ZK8j4Jkzmmepa0BJvdDBBN5 |
2 |
|
The document is a Soil Adsorption/Desorption Study of Potassium Perfluorooctanesulfonate (PFOS) conducted by 3M Environmental Laboratory, initiated on October 17, 2000, and compliant with TSCA Good Laboratory Practice standards, with noted exceptions.
|
2000 |
AR226-1030
|
LJzy5mk5pvDmB2dbqapXoR8Db |
758 |
|
The EPA is requesting additional information from 3M regarding the composition of their perfluoroalkyl submissions, specifically clarifying the identity of FC-95 and the confidentiality claims for other perfluoroalkyl sulfonates, as well as the identity of a perfluoroalkyl alcohol tested in a rat teratology study.
|
2000 |
AR226-0543
|
44NZBwjyV8o0ye3r1qZkYg5dR |
2 |
|
This document is a response from 3M to the EPA regarding additional information on their perfluoroalkyl submissions, specifically addressing the composition of potassium perfluorooctane sulfonate in test material FC-95 and toxicology studies involving a mixture of perfluoroalkyl alcohols.
|
2000 |
AR226-0544
|
KRjz5MxL8RN2G0m6dOrab50Q |
1 |
|
3M submitted a white paper titled "Sulfonated Perfluorochemicals in the Environment: Sources, Dispersion, Fate and Effects" as a supplemental notice regarding sulfonate-based fluorochemicals to the EPA under TSCA 8(e).
|
2000 |
AR226-0545
|
EkR4zwdN06nRDrLeG7J26Ng4 |
1 |
|
This document is a notification from 3M to the EPA regarding the submission of final reports for two-generation rat reproduction studies on N-Ethyl Perfluorooctyl Sulfonamido Ethanol and Perfluorooctane Sulfonate (PFOS) under TSCA 8(e).
|
2000 |
AR226-0551
|
vVgYJjQk6BeG5y5wGB25qbae8 |
1 |
|
The document is a report on an 18-day aerobic biodegradation study of perfluorooctanesulfonate-based chemistries conducted by Pace Analytical Services, sponsored by 3M, with the study directed by Cleston C. Lange, Ph.D.
|
2000 |
AR226-1030
|
RBrv4OqZ0zD2BY9OeBygoDjn |
39 |
|
The document outlines a planned one-generation reproduction study of perfluorooctane sulfonate (PFOS) in rats, detailing the study objectives, design, dosing groups, and administration procedures to gather pharmacokinetic data on PFOS in pregnant rats and their offspring.
|
2000 |
AR226-0192
|
2qX42Kj45GV8z7bLB0jRrbB2N |
5 |
|
The document is a final report on a combined oral fertility, developmental, and perinatal/postnatal reproduction toxicity study of PFOS conducted in rats, detailing the study's methods, results, and conclusions.
|
2000 |
AR226-0554
|
p2Rg08GRGXbBqkLVN22kjYXyw |
247 |
|
This document outlines a draft study protocol for a one-generation reproduction study of PFOS in female Harlan CD rats, aiming to investigate the potential protective effects of mevalonic acid and cholesterol against adverse maternal and fetal outcomes observed in a previous study, while also refining the no observed effect level (NOEL).
|
2000 |
AR226-0193
|
eEOGxvMK5MDMMwObnaeBov1m |
5 |
|
The document provides data from pre-1976 environmental studies conducted by 3M on the acute toxicity of perfluorooctanesulfonate (PFOS) ammonium salt (FC-93) to fathead minnows, including summaries and results from various tests performed in 1974.
|
2000 |
AR226-0194
|
2jvoDQrZ84y4kDy2jgYBpq13p |
11 |
|
The document lists various acute toxicity studies conducted by Biosearch Inc. and Riker Laboratories on perfluorooctane sulfonate (PFOS) and related compounds, detailing the test subjects, methodologies, and dates of the studies.
|
2000 |
AR226-0197
|
da94oEkRx3J6pxJoyj84JDR8G |
2 |
|
This document is an attachment to a letter from May 4, 2000, summarizing published studies on perfluorooctanesulfonates (PFOS) and perfluorooctanoic acid (PFOA), including various environmental and toxicological research findings.
|
2000 |
AR226-0198
|
p6XdXeGndNY1kpmrnL6bXLLE |
2 |
|
3M is providing the EPA with voluntary information regarding various perfluorooctylsulfonate (PFOS) salts, including their chemical designations and applications, as part of ongoing discussions about fluorochemistry.
|
2000 |
AR226-0200
|
k6Ew1mvYEXe9EJJLdNN0ewQQV |
3 |
|
This is a letter from Latham & Watkins to Dr. Charles Auer at the EPA, enclosing an analytical report from 3M's environmental monitoring program regarding biosphere sampling and analysis of perfluorinated materials, dated May 10, 2000.
|
2000 |
AR226-0201
|
MGXDbeX9Dyj548bZgDgXpQjak |
2 |
|
3M is providing supplemental information to the EPA regarding perfluorooctane sulfonates (PFOS), including executive summaries and a summary of a 26-week toxicity study in cynomolgus monkeys, to complete their previous submission.
|
2000 |
AR226-0203
|
Edb7kjbLNLBe0dVYx9QbdZMY4 |
8 |
|
3M is providing the EPA with additional voluntary information on perfluorooctane sulfonates and related compounds, including various CAS numbers, as part of ongoing discussions regarding fluorochemistry.
|
2000 |
AR226-0204
|
VekZqa6gN3Vkm8JwO3mzB9Zw |
51 |
|
The document contains a summary of acute toxicity studies on perfluorooctane sulfonate-related compounds, specifically PFOSAA, conducted by Biosearch, Inc. and Riker Laboratories for 3M, detailing various toxicity tests performed on rats and rabbits between 1978 and 1982.
|
2000 |
AR226-0216
|
yrpz3voZm23GdXrgJnRGEN5nE |
5 |
|
This final report details a pharmacokinetic study conducted by 3M on the test substance FC-129 (T-6054), which found that perfluorooctanesulfonate levels increased in rabbit liver samples 48 hours post intravenous dosing, indicating its potential as a marker for assessing dermal absorption.
|
2000 |
AR226-0226
|
n96BRoevrz5vGMQRNzGQnx53w |
96 |
|
The document contains attachments related to studies and information on perfluorooctane sulfonate (PFOS) and other perfluorinated compounds, including acute toxicity and genotoxicity studies conducted by Hazelton Laboratories America, Inc. for 3M, detailing various toxicity assessments in rabbits and rats.
|
2000 |
AR226-0228
|
rpoDazYwdJbxkGJ68ELLKXb77 |
17 |
|
This final report from 3M Environmental Laboratory details a single-dose dermal absorption and toxicity study of the perfluorinated compounds FC-129 (T-6051 and T-6054) in rabbits, finding that approximately 0.2% of the highest dose (12.8 mg/kg) was absorbed into the liver after 28 days.
|
2000 |
AR226-0225
|
JrxkbMbe9LrOYNVzV3Kk4rZjK |
151 |
|
The document is a correspondence from DuPont Haskell Laboratory to the EPA, providing summaries of studies conducted on Ammonium Perfluorooctanoate and Perfluorononanoate.
|
2000 |
AR226-0573
|
031Z6oX1XzQgbRBeyN7wK3Yk |
1 |
|
3M is submitting completed "Use and Exposure Information Profiles" (UEIPs) for various perfluorooctane sulfonate-related compounds to the EPA, ensuring the accuracy of industrial hygiene and release information.
|
2000 |
AR226-0575
|
3JB7JYg5GGOeab4ZQ8RjNmZQy |
3 |
|
3M is providing the EPA with comprehensive information on perfluorooctane sulfonates (PFOS) and related compounds, including health effects studies, reproductive studies, and environmental science data, as part of a voluntary effort to enhance regulatory understanding.
|
2000 |
AR226-0587
|
6bvdqyxyR2xOBLBB7xVM9DV86 |
3 |
|
3M is phasing out the manufacture of products based on perfluorooctanyl chemistry, including perfluorooctanoic acid (PFOA), due to environmental concerns and has submitted a detailed plan to the EPA outlining this transition.
|
2000 |
AR226-0588
|
pe9ZKNYoeJGbg3mdwa5pMmVBa |
11 |
|
This letter from 3M to the EPA discusses the company's response to a request for additional information regarding ongoing studies related to perfluorinated compounds, specifically indicating that certain study protocols and plans were provided, while some studies, including phytotoxicity, are still in development.
|
2000 |
AR226-0593
|
vy2jekNbLE9Bx2NMRwV2XZaZY |
2 |
|
3M submitted a "Use and Exposure Information Profile" for perfluorooctanoic acid and salts to the EPA, detailing their industrial hygiene program and exposure assessment methods used in their production facilities.
|
2000 |
AR226-0594
|
DGnZbMQYNanwQdM4RxXyVZE0o |
2 |
|
The document provides a voluntary use and exposure information profile for Perfluorooctanoic Acid (PFOA) and its salts, detailing production processes by 3M Company, including the synthesis via the Simons Electro Chemical Fluorination process and the estimated annual distribution amounts.
|
2000 |
AR226-0595
|
e7eDwJDK90RdD5Y90LgGGerrg |
28 |
|
This document from DuPont provides a summary of their U.S. uses of Ammonium Perfluorooctanoate (APFO), indicating that they do not manufacture it, that most of it is removed from products before sale, and that extensive industrial hygiene data show worker exposures are significantly below the ACGIH TLV.
|
2000 |
AR226-0598
|
kmxRb7j94jgZmNEVZGNmvmgvy |
2 |
|
3M is confirming meetings with the US EPA to present its phase-out plan for perfluorooctyl-based chemistries and discuss alternative chemistries, including perfluorobutane sulfonyl fluoride, scheduled for June 20th and June 22nd, 2000.
|
2000 |
AR226-0597
|
2RQRzJaNDEJLg8xQy4amEnMqb |
2 |
|
3M has submitted a detailed phase-out plan to the EPA for products based on perfluorooctanesulfonyl fluoride (POSF), indicating that production will be substantially discontinued by the end of 2000, while also noting that perfluorooctanoic acid (PFOA) will be addressed separately.
|
2000 |
AR226-0600
|
aDx4ZXmqbv0w6napEX8qrdm09 |
11 |
|
DuPont's correspondence outlines their non-manufacture of PFOS and PFOA, their use of PFOA as a surfactant in fluoropolymer production, and their commitment to provide the EPA with toxicity testing and exposure information regarding these perfluorinated compounds by May 26, 2000.
|
2000 |
AR226-0604
|
JrZdVkOYJjLke4JKGOdrLn1k2 |
1 |
|
The document is an email from Charles Auer of the EPA to Gerald Kennedy of DuPont, discussing a request for an extension on the submission date for exposure information on ammonium PFOA, with a new proposed deadline of June 23, 2000, while acknowledging the need for timely submission of toxicity information on PFOS and PFOA.
|
2000 |
AR226-0605
|
rpggpnm2xavJ8eJg6LQ2VD7vq |
1 |
|
This is a letter from DuPont Haskell Laboratory for Toxicology and Industrial Medicine, dated July 6, 2000, confirming the attendance of representatives from various companies at a meeting scheduled for July 7.
|
2000 |
AR226-0606
|
vVZq0bKVvBbEZajXaLVZdk7NY |
1 |
|
This document is a note from the EPA regarding 3M's response to missing reports related to ongoing environmental studies on perfluorooctanesulfonates (PFOS), confirming the status of various studies including biodegradation and phytotoxicity.
|
2000 |
AR226-0609
|
4aebgLwKwYgkaM6qaLVOEZBOG |
6 |
|
3M submitted a TSCA Section 8(e) report to the EPA indicating that new data from their study on retired perfluorochemical production workers suggest the half-life of perfluorooctane sulfonate (PFOS) in human serum is approximately 270 days, significantly lower than the previously estimated range of 1000-1500 days.
|
2000 |
AR226-0610
|
pBEeKnjYVKrV93b8D87z7nXG7 |
2 |
|
This interim report from 3M Company discusses the determination of serum half-lives for perfluorooctanesulfonate (PFOS) and perfluorooctanoate (PFOA) in retired fluorochemical production employees, indicating that PFOS has a half-life significantly lower than previously estimated and that PFOA's half-life is approximately one year.
|
2000 |
AR226-0611
|
v1w69VxjE08VvXaznEpOyk6XR |
9 |
|
3M submitted a TSCA 8(e) substantial risk notice to the EPA regarding N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE), indicating that a 13-week dietary study in rats showed liver effects and reduced body weights at higher doses, while no significant effects were observed at the low dose of 3ppm.
|
2000 |
AR226-0614
|
RjgXX85pkjOxk0jb6BwDZZB0k |
2 |
|
The document is a submission from 3M to the EPA, dated July 12, 2000, providing a CD containing information on perfluorooctane sulfonates and related compounds, including an extensive index for document access and noting that no confidential documents are included.
|
2000 |
AR226-0612
|
MgBgLwBKwzZM3Mg9xYxGKBgL |
45 |
|
The document contains attachments to a letter discussing various acute toxicity studies and genotoxicity tests related to perfluorooctane sulfonate (PFOS) and its derivatives, specifically detailing findings from Riker Laboratories and Coming Hazelton Inc. on compounds such as N-ethyl perfluorooctanesulfonamide (N-EtFOSA).
|
2000 |
AR226-0236
|
ea9zvaQYwbZ5RgL0jRVv5Qoq |
15 |
|
This document is a final report from 3M Environmental Laboratory detailing a pharmacokinetic study of the perfluorinated compound FC-120 (T-6052) in rabbits, which found detectable levels of organic fluorine in liver samples only at higher doses.
|
2000 |
AR226-0235
|
3QVry6zDoR9JBYzbQb0XknzrE |
143 |
|
This letter discusses 3M's announcement to withdraw certain PFOS-related products from the market by the end of 2000, while requesting the inclusion of imaging material uses on a "critical use list" for continued production, and expresses a willingness to collaborate with the EPA on finding suitable replacements and addressing interim use issues.
|
2000 |
AR226-0617
|
wqoygz0Ek6KgMX9Qp4Br1314o |
1 |
|
Dynax Corporation's letter to the EPA discusses the phase-out of 3M's AFFF agents containing PFOS and PFOA, expressing disagreement with 3M's request for an extension of the phase-out deadline, while highlighting that alternative fluorochemicals produced by other manufacturers do not contain these harmful substances.
|
2000 |
AR226-0618
|
EvnwXGKzkdnKDvnk5vYgE36eg |
6 |
|
The document discusses the environmental and health concerns associated with Perfluorooctyl Sulfonate (PFOS), produced primarily by 3M Company, highlighting its persistence, bioaccumulation, and toxicity, as well as its widespread presence in the blood of the general US population and wildlife.
|
2000 |
AR226-0619
|
82nn78Br4pRopGMZpbDXDzVpm |
17 |
|
The document is a report prepared by 3M detailing the sources, environmental dispersion, fate, and effects of sulfonated perfluorochemicals, including PFOA and PFOS, as of March 1, 2000.
|
2000 |
AR226-0620
|
zm4y7bvb4bMzeXgmZmYOQ8R |
51 |
|
Unreadable document.
|
2000 |
AR226-0623
|
JJ2j39N527RLjpxJ1K8jp58L2 |
1 |
|
The document details various reproductive and toxicological studies conducted by 3M Medical Department on perfluorooctane sulfonate (PFOS), including findings on perinatal mortality, cholesterol metabolism effects, and serum concentration responses, as of March 7, 2000.
|
2000 |
AR226-0625
|
8VmNZMpB8aEeNK7gwjLY6ayRK |
11 |
|
The document outlines the objectives of a meeting between the EPA and 3M regarding the management of perfluorinated compounds (PFCs), specifically focusing on product stewardship, risk assessments, and future communications related to 3M's initiatives involving perfluorooctane sulfonyl fluoride and its commercial applications.
|
2000 |
AR226-0626
|
V3wzB2qp0q2GK5bJwkL72DzVZ |
11 |
|
This is a facsimile transmission from Latham & Watkins dated April 27, 2000, intended for Charles Auer and Oscar Hernandez at the EPA, containing confidential information.
|
2000 |
AR226-0628
|
wDVNRENYMoeoa74keVmNDwqx6 |
3 |
|
The document discusses the phaseout of PFOS (perfluorooctane sulfonate) and highlights an important development regarding its status as a persistent, bioaccumulative, and toxic chemical, with plans to engage the OECD Secretariat for further discussion.
|
2000 |
AR226-0629
|
aB9mMbwG62QQopxgymRO14Xn9 |
6 |
|
The document is a letter from the EPA's Charles M. Auer to Dr. William A. Weppner of 3M Corporation, requesting assistance in arranging a meeting with global fluorochemical manufacturers regarding recent developments on PFOS.
|
2000 |
AR226-0630
|
5DmgNVXRV36rRKXN5DXnJo9M0 |
1 |
|
Dainippon Ink & Chemicals, Inc. communicated to the EPA their intention to phase out products containing PFOS in response to regulatory discussions, while seeking clarification on potential regulations affecting their customers who export PFOS-containing products to the U.S.
|
2000 |
AR226-0631
|
b5kamg6Y6OpMvk4qeEE4MxeYk |
2 |
|
The document discusses the OECD's approach to assessing PFOS and its derivatives in light of 3M Corporation's decision to phase out production for most uses, highlighting collaborative efforts among member countries to prepare a screening level risk assessment addressing human and environmental hazards, uses, and potential substitutes.
|
2000 |
AR226-0632
|
jRGNgpbQkB41QQykQYmb0J8O |
2 |
|
The document is a correspondence from the EPA to 3M regarding the submission of test data on perfluorochemicals, specifically outlining the requirements for acute systemic toxicity studies, skin and eye irritation studies, and bibliographic listings of prior studies, with a focus on studies conducted from 1976 onwards.
|
2000 |
AR226-0633
|
LKBY72QBXZmg8RVXo7E4BLj8g |
2 |
|
The document is a request from the EPA for information on perfluorinated chemicals, specifically focusing on PFOA and PFOS, including health effects, environmental studies, and exposure data, with deadlines for submission of the requested information.
|
2000 |
AR226-0634
|
wDVR9XGgwGmvYNaVby59QKnLo |
2 |
|
The document is a follow-up email from Barbara Leczynski of the EPA to 3M regarding a meeting on April 28, 2000, discussing the extension for 3M to provide information on PFOS, expectations for interim reports, and the submission of relevant data to evaluate the hazards and risks associated with PFOS and other perfluorinated compounds.
|
2000 |
AR226-0636
|
bBK6wwQzaa3DQn5ejD5EQQ3j6 |
1 |
|
The document is a request from the EPA for 3M to provide complete final reports and relevant information on PFOS and other perfluorinated compounds, including health and environmental effects studies, within specified deadlines.
|
2000 |
AR226-0635
|
93eJOMbvz08OJZRYxkjd0VRYD |
2 |
|
3M is coordinating a meeting with the EU Commission to discuss PFOS and will provide additional information on PFOS mixtures, PFOA, and other derivatives by specified dates in May and June 2000.
|
2000 |
AR226-0637
|
DM32yVR6E1JzKn9y92mGb3yVM |
1 |
|
The document presents an overview of PFOS (perfluorooctane sulfonic acid), detailing its production by 3M Corporation, widespread environmental and biological presence, and significant health effects observed in studies, including developmental toxicity in rats and accumulation in humans and wildlife.
|
2000 |
AR226-0639
|
VGJyYGOj3gKZXGLMaoOpNGwgo |
3 |
|
3M announced it is phasing out the production of perfluorooctanyl chemistry, including certain Scotchgard products and fire-fighting foams, due to increasing scrutiny on persistent materials, despite existing evidence suggesting these compounds do not pose significant health or environmental risks.
|
2000 |
AR226-0641
|
102B1zpL17Jn3ZZe9eqbB4Jqd |
2 |
|
The final report from 3M Environmental Laboratory indicates that a single-dose dermal absorption study of the fluorochemical FC-120 (T-6052) in rabbits showed no significant organic fluorine absorption at the highest dose of 1000 mg/kg, with only trace amounts detectable, suggesting the doses were insufficient to assess dermal absorption effectively.
|
2000 |
AR226-0234
|
qdXBDnKaBGpZqq3gZw3NYBwV5 |
183 |
|
The document contains various toxicity and genotoxicity study reports on N-methyl perfluorooctanesulfonamide (N-MeFOSA) conducted by Hazleton Laboratories America, Inc. for 3M, detailing acute oral toxicity, primary dermal irritation, primary eye irritation, and microbiological mutagenicity assays.
|
2000 |
AR226-0242
|
jmryBrjzoLNqeX9YNe7zVLObp |
51 |
|
Dainippon Ink & Chemicals Inc. is requesting a meeting with the U.S. EPA on September 15, 2000, to discuss issues related to PFOS, with Mr. Ehara attending on behalf of the company.
|
2000 |
AR226-0642
|
7R6nxmxwpE3JJBXGvMOwXvRJj |
1 |
|
The document is a letter from the EPA to Dainippon Ink & Chemicals, Inc. regarding their decision to phase out perfluorooctyl sulfonate (PFOS) for certain uses, while expressing the Agency's willingness to discuss critical uses and potential substitutes due to concerns about PFOS's persistence in the environment and its potential health risks.
|
2000 |
AR226-0643
|
MMvKZQNpV43Z0Ez0gNYQm96ja |
2 |
|
3M submitted additional information to the EPA regarding perfluorooctane sulfonates and related compounds, while designating one specific environmental study as confidential business information (CBI).
|
2000 |
AR226-0644
|
oe6GN1x9Ne8x0EjMqJ6p73Xro |
11 |
|
The document is a final report of a 4-week range-finding dietary toxicity study conducted by Covance Laboratories on N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE, T-6314) for the sponsor 3M.
|
2000 |
AR226-0616
|
mBYxK5321eoOaG3we1jLbDGpb |
374 |
|
The document contains attachments related to studies and information on perfluorooctane sulfonate (PFOS) and its related compounds, including acute toxicity, genotoxicity, and repeated-dose toxicity studies conducted by Hazelton Laboratories and International Research and Development Corporation.
|
2000 |
AR226-0249
|
oMooVe78Oj6Q7xp5NXYNEdJxX |
20 |
|
3M Corporation announced its decision to voluntarily discontinue the manufacture of 90 PFOS chemicals, including those used in AFFF products, by the end of 2002 due to concerns about PFOS's persistence and toxicity, prompting the EPA to propose a significant new use rule requiring notification for any future manufacturing or importing of these chemicals.
|
2000 |
AR226-0998
|
rYBXvkLgyV0ovKoMNmx4QYVE |
5 |
|
The document is a final report on a 13-week dietary toxicity study of N-Methyl Perfluorooctanesulfonamido Ethanol (N-MeFOSE, T-6314) conducted in rats, sponsored by 3M and performed by Covance Laboratories Inc.
|
2000 |
AR226-0991
|
x6RQVNn4562yRQEpgXEo7goE |
560 |
|
Following negotiations, 3M announced it will voluntarily phase out perfluorooctanyl sulfonate (PFOS) chemistry used in various products, with the EPA indicating it will monitor the situation and take further regulatory actions if necessary.
|
2000 |
AR226-0000
|
Byq4d5v0X3zwgXemXxLGY08Lm |
1 |
|
This document is a correspondence from Larry R. Zobel of 3M to Dr. Oscar Hernandez at the EPA, providing additional documents related to studies on PFOS and PFOA that were inadvertently omitted from a previous package.
|
2000 |
AR226-0001
|
v1zO4VjERBm0x9rg4x8dgyrRE |
1 |
|
This letter from 3M's Medical Director, Larry R. Zobel, clarifies findings from a two-generation reproduction study on potassium perfluorooctanesulfonate (PFOS), stating that there were no significant effects on pup survival or growth at the 0.4 mg/kg/day dose, contrary to previous report language.
|
2000 |
AR226-0002
|
jNgGvaY0G1LkQZdpGq4oB76gp |
6 |
|
3M is providing the EPA with additional voluntary information on perfluorooctanesulfonate (PFOS), including studies on pharmacokinetics, teratology, and epidemiology, as part of ongoing discussions regarding fluorochemistry.
|
2000 |
AR226-0003
|
GKg1vGYakJOkxKx9RZv8N9rm7 |
10 |
|
The document details a series of studies conducted by 3M on dermal absorption and pharmacokinetics of perfluorooctanesulfonate (PFOS) in New Zealand white rabbits to assess the absorption capacity of low-molecular-weight manufacturing residuals and establish detection limits for PFOS and fluoride ion as markers of dermal absorption.
|
2000 |
AR226-0009
|
6B5157Eej2koXOVywd9zLZmB9 |
4 |
|
The document summarizes an oral developmental toxicity study of potassium perfluorooctanesulfonate (PFOS) in rats, conducted by Riker Laboratories, which found maternal toxicity at the highest dose but no evidence of fetal toxicity, although a significant increase in developmental eye abnormalities was noted across all dose groups.
|
2000 |
AR226-0013
|
mBqgj18qwgB66OO7pkj44nOBd |
3 |
|
The document is a final report from 3M Environmental Laboratory detailing an analytical study on the pharmacokinetics of the fluorochemical FC-95 (T-6049) in rabbits, which confirmed the presence of perfluorooctanesulfonate in liver and serum after intravenous dosing.
|
2000 |
AR226-0012
|
2EVa9Ny5BrD7nV8V8RBBz5bR |
82 |
|
This document is a final report from 3M Environmental Laboratory detailing an analytical study on the dermal absorption and toxicity of FC-95 (T-6049), a potassium salt of perfluorooctanesulfonic acid (PFOS), in rabbits, concluding that no detectable dermal absorption occurred at the tested low dose levels.
|
2000 |
AR226-0011
|
NDmX1EY2j5rZw3X1BD9a9X4E |
95 |
|
The document is a supplemental submission detailing the fluorochemical characterization of surface water samples from multiple cities, including Columbus, GA, Cleveland, TN, Decatur, AL, Mobile, AL, Pensacola, FL, and Port St. Lucie, FL, as part of a multi-city study conducted by various laboratories, including Centre Analytical Laboratories and Battelle Memorial Institute.
|
2000 |
AR226-0670
|
0grn58DmYdvkzBYKeKaQ0bBdm |
11 |
|
The document outlines various analytical methods developed by 3M Environmental Laboratory for the extraction and analysis of Potassium Perfluorooctanesulfonate (PFOS) and other fluorochemicals from serum, liver, and urine using HPLC-Electrospray/Mass Spectrometry, detailing method numbers and adoption dates.
|
2000 |
AR226-0024
|
BjELLb6MGng5pvwvXwe1Bvem |
15 |
|
Pace Analytical Services, Inc. conducted resampling for PFOS and other fluorochemicals in Port St. Lucie, Florida, under contract with 3M to confirm baseline data from a previous study.
|
2000 |
AR226-0680
|
8rngrJxK9pybrN9JdBL3dJ1B |
13 |
|
The document discusses the monitoring of perfluorinated surfactants, particularly PFOA and PFOS, in biota and surface water samples following a 2000 accidental release of fire-fighting foam at L. B. Pearson International Airport into Etobicoke Creek, highlighting concerns over their environmental persistence and toxicity.
|
2000 |
AR226-1061
|
JJxJaV1Zn7o9qV3KNvrndoRDa |
8 |
|
This document is a correspondence from 3M confirming the submission of a non-confidential version of a toxicological study on perfluorooctane sulfonates to the EPA, following a request for such information.
|
2000 |
AR226-0037
|
DGp8ay1GDnV4q0DKOzgm0qyjQ |
1 |
|
3M is requesting a one-week extension to respond to the EPA's request for information on perfluorooctane sulfonic acid (PFOS) due to operational disruptions and seeks clarification on related questions before their upcoming meeting with the EPA.
|
2000 |
AR226-0041
|
Y3XO6VRdj1DJjZZO1ZJ6KwON |
1 |
|
This is a letterhead cover page from the EPA's Office of Prevention, Pesticides and Toxic Substances, with no analytical content retained in the OCR.
|
2000 |
AR226-0040
|
dB74GdMQoepJp2O36MxeGrN0 |
5 |
|
This document is a letter from 3M to the EPA detailing the voluntary submission of data on perfluorooctane sulfonic acid (PFOS) and its salt forms, emphasizing that the majority of their fluorochemical production involves higher molecular weight derivatives and that they are actively working to reduce manufacturing residuals.
|
2000 |
AR226-0042
|
rxgpLQOM2xgdeBnOEb47Q1eaG |
2 |
|
3M is providing the EPA with additional voluntary information on perfluorooctane sulfonates, including various CAS numbers and summaries of studies related to their environmental properties and health effects, as part of ongoing discussions about fluorochemistry.
|
2000 |
AR226-0044
|
yba6aBBvV2dvxY571Mm68vEV |
31 |
|
This document provides a voluntary use and exposure information profile for perfluorooctane sulfonates (PFOS) and their various salt forms produced by 3M Company, detailing their chemical identification, manufacturing process, and estimated off-site distribution.
|
2000 |
AR226-0043
|
qaB8KNN8Q0ZJvGoj2KNgYrgQn |
30 |
|
The document outlines various reports and studies conducted by 3M regarding the health effects and serum levels of Perfluorooctane Sulfonate (PFOS) in male employees at their fluorochemical production facilities, including epidemiologic investigations and assessments of fluorochemical exposure.
|
2000 |
AR226-0030
|
Y9pjBmZ3QqO8NY83Mk6BmqpL8 |
190 |
|
The document contains various laboratory reports and summaries related to the physical and chemical properties, solubility, and environmental fate of perfluorooctanesulfonate (PFOS) conducted by Wildlife International, Ltd. and 3M Environmental Lab.
|
2000 |
AR226-0055
|
zdXvRqVGm5QBykqz4YLzX3476 |
39 |
|
The document outlines the design and methodology of a Multi-City study submitted to 3M Environmental Laboratory, aimed at gathering preliminary data on the dispersion of fluorochemical compounds, including PFOA, in the environment, their uptake into food, and their presence in drinking water to assess potential human exposure sources.
|
2000 |
AR226-0063
|
5k8xyYQ7j9OGo0E3eVGvNMK8z |
7 |
|
The document details a dietary acute study on the effects of perfluorooctanesulfonate (PFOS) on mallard ducks, conducted by Whistling Wings, Inc., with a test substance purity of 90.49% and utilizing specific GLP methods to assess toxicity and stability over a 5-day exposure period.
|
2000 |
AR226-0102
|
e5j8g9NonMV6LX4VBea9Rg4og |
8 |
|
This document contains various studies and reports on the genotoxicity and mutagenicity of perfluorooctane sulfonate (PFOS) conducted by different laboratories, including Ames tests and chromosomal aberration assessments, primarily associated with 3M Company.
|
2000 |
AR226-0128
|
2q88Kjqj5pXVL4KMOzJ2VN37R |
12 |
|
This is a final report prepared by Battelle Memorial Institute for 3M Specialty Materials, detailing life-cycle waste stream estimates for sulfonated perfluorochemicals in the U.S. from 1997.
|
2000 |
AR226-0681
|
GE21LzLdw1ekEZwZX4Nd5dN7 |
11 |
|
3M is providing the EPA with information on perfluorooctane sulfonates (PFOS) mixtures, specifically noting that potassium perfluorooctane sulfonate is intentionally added to their aqueous fire fighting foam (AFFF) products at low levels, and that further studies on AFFF products may have limited relevance to the hazard profile of PFOS.
|
2000 |
AR226-0682
|
Rp5qyonB3X9GG5v37mgn59Don |
41 |
|
The document evaluates mutagenicity studies on perfluorooctanesulfonate (PFOS) conducted by Covance and Corning Hazleton to assess the potential mutagenic/genotoxic risk posed by PFOS, a degradation product of perfluorooctanesulfonylfluoride used by 3M.
|
2000 |
AR226-0135
|
zdOrNywgO5xX8BEDdGzwN8gVR |
12 |
|
The document contains attachments related to various toxicity studies of Perfluorooctane Sulfonate (PFOS) and Fluorad Fluorochemical Surfactant FC-95 conducted by the International Research and Development Corporation and Covance Laboratories, detailing findings from subacute and chronic toxicity studies in rhesus monkeys and rats.
|
2000 |
AR226-0137
|
qd4V55G17DZMKogLKYgGy4gYG |
41 |
|
The document details the findings from a microscopic review of liver sections from rats in a chronic PFOS study, indicating centrolobular hepatocyte hypertrophy as a compound-related change, with specific observations on the presence of lipid type cytoplasmic vacuoles in certain groups, leading to a determination of NOAEL and NOEL for liver histologic changes.
|
2000 |
AR226-0141
|
Z4LoyobZZ85Vx0xQ35p0kVGGd |
11 |